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Phlpp2 Gene Detail
Summary
  • Symbol
    Phlpp2
  • Name
    PH domain and leucine rich repeat protein phosphatase 2
  • Synonyms
    C130044A18Rik, Phlppl
  • Feature Type
    protein coding gene
  • IDs
    MGI:2444928
    NCBI Gene: 244650
  • Gene Overview
    MyGene.info: PHLPP2
Location & Maps
more
  • Sequence Map
    Chr8:109868542-109944671 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      76130 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 57.33 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    PHLPP2, PH domain and leucine rich repeat protein phosphatase 2
  • Vertebrate Orthologs
    9
  • Human Ortholog
    PHLPP2, PH domain and leucine rich repeat protein phosphatase 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    PHLPPL, PPM3B
  • Links
    NCBI Gene ID: 23035
    neXtProt AC: NX_Q6ZVD8

  • Chr Location
    16q22.2; chr16:71644924-71724701 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    2 phenotypes from multigenic genotypes
    3 phenotype references
Mice homozygous for a knock-out allele exhibit normal susceptibility to DSS-induced colitis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000034048 VEGA Gene Model | MGI Sequence Detail 76130 C57BL/6J ±  kb
transcript OTTMUST00000085979 VEGA | MGI Sequence Detail 7839 Not Applicable  
polypeptide OTTMUSP00000046493 VEGA | MGI Sequence Detail 1320 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    224 from dbSNP Build 142
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000012668 PH domain leucine-rich repeat-containing protein phosphatase 2
  • EC
  • InterPro Domains
    IPR001611 Leucine-rich repeat
    IPR032675 Leucine-rich repeat domain, L domain-like
    IPR003591 Leucine-rich repeat, typical subtype
    IPR011993 PH domain-like
    IPR001932 PPM-type phosphatase domain
Molecular
Reagents
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  • All nucleic 30
    cDNA 30

    Microarray probesets 4
Other
Accession IDs
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MGI:2142574
References
more
  • Summaries
    All 29
    Developmental Gene Expression 1
    Gene Ontology 5
    Phenotypes 3
  • Earliest
    J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
  • Latest
    J:231241 Wen YA, et al., Loss of PHLPP protects against colitis by inhibiting intestinal epithelial cell apoptosis. Biochim Biophys Acta. 2015 Oct;1852(10 Pt A):2013-23

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
09/27/2016
MGI 6.05
The Jackson Laboratory