About   Help   FAQ
Phlpp2 Gene Detail
Summary
  • Symbol
    Phlpp2
  • Name
    PH domain and leucine rich repeat protein phosphatase 2
  • Synonyms
    C130044A18Rik, Phlppl
  • Feature Type
    protein coding gene
  • IDs
    MGI:2444928
    NCBI Gene: 244650
  • Gene Overview
    MyGene.info: PHLPP2
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:109868542-109944671 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 57.33 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    224 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2444928
protein coding gene Chr8:109868520-109944671 (.)
129S1/SvImJ MGP_129S1SvImJ_G0034115
protein coding gene Chr8:112484645-112560336 (+)
A/J MGP_AJ_G0034094
protein coding gene Chr8:107927318-107999628 (+)
AKR/J MGP_AKRJ_G0034021
protein coding gene Chr8:111089097-111166112 (+)
BALB/cJ MGP_BALBcJ_G0034088
protein coding gene Chr8:108133046-108206589 (+)
C3H/HeJ MGP_C3HHeJ_G0033799
protein coding gene Chr8:111798679-111871712 (+)
C57BL/6NJ MGP_C57BL6NJ_G0034608
protein coding gene Chr8:116453603-116529652 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031550
protein coding gene Chr8:100955838-101033850 (+)
CAST/EiJ MGP_CASTEiJ_G0033126
protein coding gene Chr8:111399554-111483688 (+)
CBA/J MGP_CBAJ_G0033773
protein coding gene Chr8:120366866-120449226 (+)
DBA/2J MGP_DBA2J_G0033928
protein coding gene Chr8:107251923-107324655 (+)
FVB/NJ MGP_FVBNJ_G0033872
protein coding gene Chr8:106201616-106273153 (+)
LP/J MGP_LPJ_G0034018
protein coding gene Chr8:112661613-112738409 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033918
protein coding gene Chr8:123382951-123469044 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0034627
protein coding gene Chr8:111050168-111127052 (+)
PWK/PhJ MGP_PWKPhJ_G0032829
protein coding gene Chr8:106808384-106888908 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032668
protein coding gene Chr8:109732729-109812529 (+)
WSB/EiJ MGP_WSBEiJ_G0033242
protein coding gene Chr8:111735391-111816102 (+)



Homology
more
  • Human Ortholog
    PHLPP2, PH domain and leucine rich repeat protein phosphatase 2
  • Vertebrate Orthologs
    9
  • Human Ortholog
    PHLPP2, PH domain and leucine rich repeat protein phosphatase 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    PHLPPL, PPM3B
  • Links
    NCBI Gene ID: 23035
    neXtProt AC: NX_Q6ZVD8
    UniProt: Q6ZVD8

  • Chr Location
    16q22.2; chr16:71644924-71724701 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    2 phenotypes from multigenic genotypes
    5 phenotype references
Mice homozygous for a knock-out allele exhibit normal susceptibility to DSS-induced colitis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000031732 Ensembl Gene Model | MGI Sequence Detail 76130 C57BL/6J ±  kb
transcript ENSMUST00000179721 Ensembl | MGI Sequence Detail 7846 Not Applicable  
polypeptide ENSMUSP00000136166 Ensembl | MGI Sequence Detail 1355 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 31
    cDNA 31

    Microarray probesets 4
Other
Accession IDs
less
MGI:2142574
References
more
  • Summaries
    All 33
    Developmental Gene Expression 1
    Gene Ontology 7
    Phenotypes 5
  • Earliest
    J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
  • Latest
    J:256165 Kim K, et al., Degradation of PHLPP2 by KCTD17, via a Glucagon-Dependent Pathway, Promotes Hepatic Steatosis. Gastroenterology. 2017 Dec;153(6):1568-1580.e10

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
11/06/2018
MGI 6.13
The Jackson Laboratory