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Abra Gene Detail
Summary
  • Symbol
    Abra
  • Name
    actin-binding Rho activating protein
  • Synonyms
    C130068O12Rik, STARS
  • Feature Type
    protein coding gene
  • IDs
    MGI:2444891
    NCBI Gene: 223513
  • Gene Overview
    MyGene.info: ABRA
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:41865293-41869720 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 15, 16.42 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    99 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2444891
protein coding gene Chr15:41864076-41869720 (-)
129S1/SvImJ MGP_129S1SvImJ_G0021822
protein coding gene Chr15:40417456-40421865 (-)
A/J MGP_AJ_G0021782
protein coding gene Chr15:38846834-38851242 (-)
AKR/J MGP_AKRJ_G0021763
protein coding gene Chr15:40035943-40040352 (-)
BALB/cJ MGP_BALBcJ_G0021789
protein coding gene Chr15:38935460-38939887 (-)
C3H/HeJ MGP_C3HHeJ_G0021563
protein coding gene Chr15:39925544-39929953 (-)
C57BL/6NJ MGP_C57BL6NJ_G0022228
protein coding gene Chr15:41964345-41968772 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019765
protein coding gene Chr15:36518891-36523247 (-)
CAST/EiJ MGP_CASTEiJ_G0021080
protein coding gene Chr15:40427639-40432050 (-)
CBA/J MGP_CBAJ_G0021532
protein coding gene Chr15:43420760-43425172 (-)
DBA/2J MGP_DBA2J_G0021656
protein coding gene Chr15:38691200-38695616 (-)
FVB/NJ MGP_FVBNJ_G0021634
protein coding gene Chr15:38020781-38025189 (-)
LP/J MGP_LPJ_G0021726
protein coding gene Chr15:40222503-40226912 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0021658
protein coding gene Chr15:46458592-46463012 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0022251
protein coding gene Chr15:40206502-40210908 (-)
PWK/PhJ MGP_PWKPhJ_G0020825
protein coding gene Chr15:38735961-38740375 (-)
SPRET/EiJ MGP_SPRETEiJ_G0020662
protein coding gene Chr15:39851161-39855554 (-)
WSB/EiJ MGP_WSBEiJ_G0021135
protein coding gene Chr15:40112893-40117305 (-)



Homology
more
  • Human Ortholog
    ABRA, actin binding Rho activating protein
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ABRA, actin binding Rho activating protein
    Orthology source: HGNC, HomoloGene
  • Synonyms
    STARS
  • Links
    NCBI Gene ID: 137735
    neXtProt AC: NX_Q8N0Z2
    UniProt: Q8N0Z2

  • Chr Location
    8q23.1; chr8:106759483-106770244 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 34713
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: ABRA
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit impaired arteriogenesis following occlusion.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 223513 NCBI Gene Model | MGI Sequence Detail 4428 C57BL/6J ±  kb
transcript NM_175456 RefSeq | MGI Sequence Detail 1762 C57BL/6  
polypeptide Q8BUZ1 UniProt | EBI | MGI Sequence Detail 375 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 15
    cDNA 15

    Microarray probesets 3
References
more
  • Summaries
    All 39
    Developmental Gene Expression 6
    Gene Ontology 8
    Phenotypes 8
  • Earliest
    J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
  • Latest
    J:260112 Filipova D, et al., Distinct transcriptomic changes in E14.5 mouse skeletal muscle lacking RYR1 or Cav1.1 converge at E18.5. PLoS One. 2018;13(3):e0194428

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/04/2018
MGI 6.13
The Jackson Laboratory