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Fam65b Gene Detail
Summary
  • Symbol
    Fam65b
  • Name
    family with sequence similarity 65, member B
  • Synonyms
    1700108N18Rik, 6330500D04Rik, E430013J17Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2444879
    NCBI Gene: 193385
  • Gene Overview
    MyGene.info: FAM65B
Location & Maps
more
  • Sequence Map
    Chr13:24582189-24733816 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      151628 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 13, 10.50 cM, cytoband A3.2
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    FAM65B, family with sequence similarity 65 member B
  • Vertebrate Orthologs
    10
  • Human Ortholog
    FAM65B, family with sequence similarity 65 member B
    Orthology source: HomoloGene
  • Synonyms
    C6orf32, DFNB104, DIFF40, DIFF48, MYONAP, PL48
  • Links
    NCBI Gene ID: 9750
    neXtProt AC: NX_Q9Y4F9

  • Chr Location
    6p22.3-p21.32; chr6:24804281-25042288 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 9284
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: FAM65B
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with human FAM65B associations

Human Disease Mouse Models
       Deafness, Autosomal Recessive 104; DFNB104   OMIM: 616515
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    12 phenotype references
  • All Mutations and Alleles
    5
  • Chemically induced (other)
    1
  • Radiation induced
    1
  • Targeted
    3
  • Genomic Mutations
    2 involving Fam65b
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000000609 VEGA Gene Model | MGI Sequence Detail 151628 C57BL/6J ±  kb
transcript OTTMUST00000001209 VEGA | MGI Sequence Detail 5608 Not Applicable  
polypeptide OTTMUSP00000000566 VEGA | MGI Sequence Detail 1078 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    2285 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 77
    cDNA 77

    Microarray probesets 5
Other
Accession IDs
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MGI:1923872, MGI:2145192
References
more
  • Summaries
    All 34
    Developmental Gene Expression 2
    Gene Ontology 6
    Phenotypes 12
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:215951 Balasubramanian A, et al., Fam65b is important for formation of the HDAC6-dysferlin protein complex during myogenic cell differentiation. FASEB J. 2014 Jul;28(7):2955-69

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory