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Ncoa7 Gene Detail
Summary
  • Symbol
    Ncoa7
  • Name
    nuclear receptor coactivator 7
  • Synonyms
    9030406N13Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2444847
    NCBI Gene: 211329
  • Alliance
  • Transcription Start Sites
    15 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:30521578-30683401 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 17.11 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    706 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2444847
protein coding gene Chr10:30504995-30683401 (-)
129S1/SvImJ MGP_129S1SvImJ_G0017118
protein coding gene Chr10:28858025-29030857 (-)
A/J MGP_AJ_G0017095
protein coding gene Chr10:28012539-28170885 (-)
AKR/J MGP_AKRJ_G0017055
protein coding gene Chr10:28451839-28616519 (-)
BALB/cJ MGP_BALBcJ_G0017058
protein coding gene Chr10:28095406-28259255 (-)
C3H/HeJ MGP_C3HHeJ_G0016878
protein coding gene Chr10:28723900-28885388 (-)
C57BL/6NJ MGP_C57BL6NJ_G0017516
protein coding gene Chr10:29714716-29890048 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015214
protein coding gene Chr10:26456583-26605246 (-)
CAST/EiJ MGP_CASTEiJ_G0016457
protein coding gene Chr10:28783253-28959950 (-)
CBA/J MGP_CBAJ_G0016852
protein coding gene Chr10:31129636-31304848 (-)
DBA/2J MGP_DBA2J_G0016957
protein coding gene Chr10:27686404-27860937 (-)
FVB/NJ MGP_FVBNJ_G0016952
protein coding gene Chr10:27303425-27463495 (-)
LP/J MGP_LPJ_G0017034
protein coding gene Chr10:28872359-29034463 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0016982
protein coding gene Chr10:31332657-31499852 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0017552
protein coding gene Chr10:28366126-28531065 (-)
PWK/PhJ MGP_PWKPhJ_G0016239
protein coding gene Chr10:27456425-27618630 (-)
SPRET/EiJ MGP_SPRETEiJ_G0016023
protein coding gene Chr10:28310398-28477897 (-)
WSB/EiJ MGP_WSBEiJ_G0016520
protein coding gene Chr10:28504423-28668411 (-)



Homology
more
  • Human Ortholog
    NCOA7, nuclear receptor coactivator 7
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NCOA7, nuclear receptor coactivator 7
  • Synonyms
    dJ187J11.3, ERAP140, ESNA1, Nbla00052, Nbla10993, NCOA7-AS, TLDC4
  • Links
    NCBI Gene ID: 135112
    neXtProt AC: NX_Q8NI08
    UniProt: Q8NI08

  • Chr Location
    6q22.31-q22.32; chr6:125780948-125932030 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 1 allele in 1 genetic background
    2 phenotypes from multigenic genotypes
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous knockout affects lysosomal function in cortical neurons and in kidneys, leading to alkalinization of neuron somas and of urine. It also affects neuronal development, leading to anxiety and social impairments.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 211329 NCBI Gene Model | MGI Sequence Detail 161824 C57BL/6J ±  kb
    transcript NM_172495 RefSeq | MGI Sequence Detail 5353 C57BL/6  
    polypeptide Q6DFV7 UniProt | EBI | MGI Sequence Detail 943 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 58
      cDNA 54
      Primer pair 3
      Other 1

      Microarray probesets 2
    References
    more
    • Summaries
      All 37
      Developmental Gene Expression 4
      Gene Ontology 3
      Phenotypes 15
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:305611 Castroflorio E, et al., The Ncoa7 locus regulates V-ATPase formation and function, neurodevelopment and behaviour. Cell Mol Life Sci. 2021 Apr;78(7):3503-3524

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    last database update
    08/03/2022
    MGI 6.21
    The Jackson Laboratory