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Negr1
Gene Detail
Symbol

Name
ID
Negr1
neuronal growth regulator 1
MGI:2444846
Synonyms
5330422G01Rik, Ntra
Feature Type
protein coding gene
Genetic Map
Chromosome 3
80.60 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr3:156561794-157316445 bp, + strand
From VEGA annotation of GRCm38

  754652 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:41447  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: NEGR1
Gene Tree: Negr1

Human
homologs
NEGR1, neuronal growth regulator 1
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 257194
neXtProt AC: NX_Q7Z3B1

Human Synonyms: DMML2433, IGLON4, KILON, Ntra

Human Chr (Location): 1p31.1; chr1:71402942-72282847 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Chemically induced (ENU)(1) Gene trapped(1) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out or ENU-induced allele exhibit reduced body weight.
 
Interactions
Negr1 interacts with 400 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (16 annotations)
Process cell adhesion, feeding behavior, ...
Component anchored component of membrane, cell-cell junction, ...
Function molecular_function
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (145)    Tissues (139)    Images (20)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 140
RT-PCR 5
cDNA source data(10)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase negr1 ; ZFIN negr1    NEW 
Molecular
reagents
All nucleic(14) cDNA(10) Primer pair(2) Other(2)
Microarray probesets(2)
Other database
links
VEGA Gene Model OTTMUSG00000024007 (Evidence)
Ensembl Gene Model ENSMUSG00000040037 (Evidence)
Entrez Gene 320840 (Evidence)
DFCI TC1590147, TC1586007, TC1651127, TC1592714
DoTS DT.60103444, DT.101377473, DT.101137884
NIA Mouse Gene Index U004017
Consensus CDS Project CCDS17930.1, CCDS17931.1
International Mouse Phenotyping Consortium Status Negr1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000024007 VEGA Gene Model | MGI Sequence Detail 754652 C57BL/6J ±  kb
transcript OTTMUST00000058682 VEGA | MGI Sequence Detail 4983 Not Applicable 
polypeptide OTTMUSP00000028476 VEGA | MGI Sequence Detail 348 Not Applicable 

For the selected sequences
All sequences(52) RefSeq(10) UniProt(4)
Polymorphisms
SNPs within 2kb(5269 from dbSNP Build 137)    SNPs within 2kb including multiple locations(5275)
Protein-related
information
ResourceIDDescription
InterPro IPR013098 Immunoglobulin I-set
InterPro IPR007110 Immunoglobulin-like domain
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR003599 Immunoglobulin subtype
InterPro IPR003598 Immunoglobulin subtype 2
Protein Ontology PR:000011121 neuronal growth regulator 1
References
(Earliest) J:84972 Marg A, et al., Neurotractin, a novel neurite outgrowth-promoting Ig-like protein that interacts with CEPU-1 and LAMP. J Cell Biol. 1999 May 17;145(4):865-76
(Latest) J:189719 Lee AW, et al., Functional inactivation of the genome-wide association study obesity gene neuronal growth regulator 1 in mice causes a body mass phenotype. PLoS One. 2012;7(7):e41537
All references(36)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory