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Negr1 Gene Detail
Summary
  • Symbol
    Negr1
  • Name
    neuronal growth regulator 1
  • Synonyms
    5330422G01Rik, Ntra
  • Feature Type
    protein coding gene
  • IDs
    MGI:2444846
    NCBI Gene: 320840
  • Gene Overview
    MyGene.info: NEGR1
Location & Maps
more
  • Sequence Map
    Chr3:156561794-157316445 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      754652 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 80.60 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    NEGR1, neuronal growth regulator 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    NEGR1, neuronal growth regulator 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    DMML2433, IGLON4, KILON, Ntra
  • Links
    NCBI Gene ID: 257194
    neXtProt AC: NX_Q7Z3B1

  • Chr Location
    1p31.1; chr1:71402942-72282847 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 41447
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed
  • HCOP
    human homology predictions: NEGR1
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    8 phenotypes from 2 alleles in 3 genetic backgrounds
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    7
  • Chemically induced (ENU)
    1
  • Gene trapped
    1
  • Targeted
    5
  • Incidental Mutations
Mice homozygous for a knock-out or ENU-induced allele exhibit reduced body weight.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000024007 VEGA Gene Model | MGI Sequence Detail 754652 C57BL/6J ±  kb
transcript OTTMUST00000058682 VEGA | MGI Sequence Detail 4983 Not Applicable  
polypeptide OTTMUSP00000028476 VEGA | MGI Sequence Detail 348 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    5214 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
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  • All nucleic 14
    cDNA 10
    Primer pair 2
    Other 2

    Microarray probesets 2
References
more
  • Summaries
    All 34
    Developmental Gene Expression 5
    Gene Ontology 4
    Phenotypes 8
  • Earliest
    J:84972 Marg A, et al., Neurotractin, a novel neurite outgrowth-promoting Ig-like protein that interacts with CEPU-1 and LAMP. J Cell Biol. 1999 May 17;145(4):865-76
  • Latest
    J:229257 Gu Z, et al., Expression of the immunoglobulin superfamily cell adhesion molecules in the developing spinal cord and dorsal root ganglion. PLoS One. 2015;10(3):e0121550

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/23/2016
MGI 6.05
The Jackson Laboratory