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Camkk2 Gene Detail
Summary
  • Symbol
    Camkk2
  • Name
    calcium/calmodulin-dependent protein kinase kinase 2, beta
  • Synonyms
    6330570N16Rik, mKIAA0787
  • Feature Type
    protein coding gene
  • IDs
    MGI:2444812
    NCBI Gene: 207565
  • Gene Overview
    MyGene.info: CAMKK2
Location & Maps
more
  • Sequence Map
    Chr5:122731170-122779409 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      48240 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 62.55 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    CAMKK2, calcium/calmodulin dependent protein kinase kinase 2
  • Vertebrate Orthologs
    9
  • Human Ortholog
    CAMKK2, calcium/calmodulin dependent protein kinase kinase 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CAMKK, CAMKKB
  • Links
    NCBI Gene ID: 10645
    neXtProt AC: NX_Q96RR4

  • Chr Location
    12q24.2; chr12:121237692-121298308 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    16 phenotypes from 3 alleles in 3 genetic backgrounds
    3 phenotypes from multigenic genotypes
    28 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    41
  • Chemically induced (other)
    1
  • Gene trapped
    32
  • Radiation induced
    1
  • Targeted
    7
  • Genomic Mutations
    2 involving Camkk2
  • Incidental Mutations
Inactivation of this locus results in impaird long term potentiation and defects in some types of long term memory.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000054556 VEGA Gene Model | MGI Sequence Detail 48240 C57BL/6J ±  kb
transcript OTTMUST00000135235 VEGA | MGI Sequence Detail 4861 Not Applicable  
polypeptide OTTMUSP00000071593 VEGA | MGI Sequence Detail 588 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    231 from dbSNP Build 142
Protein
Information
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  • UniProt
    7 Sequences
  • Protein Ontology
    PR:000004995 calcium/calmodulin-dependent protein kinase kinase 2
  • EC
  • InterPro Domains
    IPR020636 Calcium/calmodulin-dependent/calcium-dependent protein kinase
    IPR017441 Protein kinase, ATP binding site
    IPR000719 Protein kinase domain
    IPR011009 Protein kinase-like domain
    IPR008271 Serine/threonine-protein kinase, active site
Molecular
Reagents
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  • All nucleic 50
    cDNA 50

    Microarray probesets 4
Other
Accession IDs
less
MGI:2141148
References
more
  • Summaries
    All 57
    Developmental Gene Expression 3
    Gene Ontology 5
    Phenotypes 28
  • Earliest
    J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-le-grand). 1999 Jul;45(5):737-50
  • Latest
    J:221964 Pritchard ZJ, et al., Inhibition of CaMKK2 reverses age-associated decline in bone mass. Bone. 2015 Jun;75:120-7

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/20/2016
MGI 6.05
The Jackson Laboratory