About   Help   FAQ
Camkk2
Gene Detail
 Symbol
Name
ID
Camkk2
calcium/calmodulin-dependent protein kinase kinase 2, beta
MGI:2444812
Synonyms 6330570N16Rik, mKIAA0787
Feature Type protein coding gene
Genetic Map
Chromosome 5
62.55 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr5:122731173-122779410 bp, - strand
From Ensembl annotation of GRCm38

  48238 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:32756  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Camkk2

Human
homologs
Human Homolog CAMKK2, calcium/calmodulin-dependent protein kinase kinase 2, beta
NCBI Gene ID 10645
neXtProt AC  NX_Q96RR4
Human Synonyms  CAMKK, CAMKKB
Human Chr (Location)  12q24.2; chr12:121237692-121298308 (-)  GRCh38
Alleles
and
phenotypes
All alleles(39) : Gene trapped(32) Targeted(7)
Incidental mutations (data from Mutagenetix , APF )
 
Inactivation of this locus results in impaird long term potentiation and defects in some types of long term memory.
 
Gene Ontology
(GO)
classifications
All GO classifications: (20 annotations)
Process activation of protein kinase activity, phosphorylation, ...
Component cell projection, cytoplasm, ...
Function ATP binding, calcium ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (114)    Tissues (17)    Images (26)
Theiler Stages: 19, 23
Assay TypeResults
RNA in situ 114
cDNA source data(50)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress
Molecular
reagents
All nucleic(50) cDNA(50)
Microarray probesets(4)
Other database
links
Ensembl Gene ModelENSMUSG00000029471 (Evidence)
Entrez Gene207565 (Evidence)
UniGene289237
DFCITC1574673, TC1591013, TC1595805, TC1601159, TC1617913, TC1629144, TC1706993
DoTSDT.101153108, DT.101736785, DT.50315747, DT.60101806, DT.94142644, DT.94246717
NIA Mouse Gene IndexU026700
EC2.7.11.17
Consensus CDS ProjectCCDS19655.1
International Mouse Knockout Project StatusCamkk2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000029471 Ensembl Gene Model | MGI Sequence Detail 48238 C57BL/6J ±  kb
transcript ENSMUST00000111668 Ensembl | MGI Sequence Detail 4843 Not Applicable 
polypeptide ENSMUSP00000107297 Ensembl | MGI Sequence Detail 541 Not Applicable 

For the selected sequences
All sequences(55) RefSeq(18) UniProt(2)
Polymorphisms SNPs within 2kb(163 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR020636 Calcium/calmodulin-dependent/calcium-dependent protein kinase
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR002290 Serine/threonine- / dual specificity protein kinase, catalytic domain
InterPro IPR008271 Serine/threonine-protein kinase, active site
Protein Ontology PR:000004995 calcium/calmodulin-dependent protein kinase kinase 2
References (Earliest) J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-le-grand). 1999 Jul;45(5):737-50
(Latest) J:198500 Nakahara M, et al., Gene-trap mutagenesis using Mol/MSM-1 embryonic stem cells from MSM/Ms mice. Mamm Genome. 2013 Jun;24(5-6):228-39
All references(55)
Other
accession IDs
MGI:2141148

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
07/15/2014
MGI 5.18
The Jackson Laboratory