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Camkk2
Gene Detail
Symbol

Name
ID
Camkk2
calcium/calmodulin-dependent protein kinase kinase 2, beta
MGI:2444812
Synonyms
6330570N16Rik, mKIAA0787
Feature Type
protein coding gene
Genetic Map
Chromosome 5
62.55 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr5:122731173-122779410 bp, - strand
From Ensembl annotation of GRCm38

  48238 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:32756  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: CAMKK2
Gene Tree: Camkk2

Human
homologs
CAMKK2, calcium/calmodulin-dependent protein kinase kinase 2, beta
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 10645
neXtProt AC: NX_Q96RR4

Human Synonyms: CAMKK, CAMKKB

Human Chr (Location): 12q24.2; chr12:121237692-121298308 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(39) : Gene trapped(32) Targeted(7)
Incidental mutations (data from Mutagenetix , APF )
 
Inactivation of this locus results in impaird long term potentiation and defects in some types of long term memory.
 
Interactions
Camkk2 interacts with 314 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (18 annotations)
Process activation of protein kinase activity, phosphorylation, ...
Component cell projection, cytoplasm, ...
Function ATP binding, calcium ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (114)    Tissues (17)    Images (26)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 114
cDNA source data(50)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: Xenbase camkk2    NEW 
Molecular
reagents
All nucleic(50) cDNA(50)
Microarray probesets(4)
Other database
links
Ensembl Gene Model ENSMUSG00000029471 (Evidence)
Entrez Gene 207565 (Evidence)
UniGene 289237
DFCI TC1706993, TC1629144, TC1601159, TC1617913, TC1591013, TC1595805, TC1574673
DoTS DT.101153108, DT.94142644, DT.94246717, DT.50315747, DT.60101806, DT.101736785
NIA Mouse Gene Index U026700
EC 2.7.11.17
Consensus CDS Project CCDS19655.1
International Mouse Phenotyping Consortium Status Camkk2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000029471 Ensembl Gene Model | MGI Sequence Detail 48238 C57BL/6J ±  kb
transcript ENSMUST00000111668 Ensembl | MGI Sequence Detail 4843 Not Applicable 
polypeptide ENSMUSP00000107297 Ensembl | MGI Sequence Detail 541 Not Applicable 

For the selected sequences
All sequences(55) RefSeq(18) UniProt(2)
Polymorphisms
SNPs within 2kb(163 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR020636 Calcium/calmodulin-dependent/calcium-dependent protein kinase
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR002290 Serine/threonine- / dual specificity protein kinase, catalytic domain
InterPro IPR008271 Serine/threonine-protein kinase, active site
Protein Ontology PR:000004995 calcium/calmodulin-dependent protein kinase kinase 2
References
(Earliest) J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-le-grand). 1999 Jul;45(5):737-50
(Latest) J:198500 Nakahara M, et al., Gene-trap mutagenesis using Mol/MSM-1 embryonic stem cells from MSM/Ms mice. Mamm Genome. 2013 Jun;24(5-6):228-39
All references(54)
Other
accession IDs
MGI:2141148

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory