Dcaf5 MGI Mouse Gene Detail - MGI:2444785 - DDB1 and CUL4 associated factor 5

Symbol

Dcaf5
Name

DDB1 and CUL4 associated factor 5
Synonyms

9430020B07Rik, BCRG2, BCRP2, mKIAA1824, Wdr22

Feature Type

protein coding gene
IDs

MGI:2444785
NCBI Gene: 320808
Alliance

gene page
Transcription Start Sites

4 TSS

Sequence Map

Chr12:80382622-80483375 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 12, 36.61 cM
Mapping Data

2 experiments

SNPs within 2kb

2811 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2444785	protein coding gene	Chr12:80382622-80483375 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0019887	protein coding gene	Chr12:80695205-80796623 (-)
A/J	MGP_AJ_G0019845	protein coding gene	Chr12:77777067-77871323 (-)
AKR/J	MGP_AKRJ_G0019820	protein coding gene	Chr12:79891602-79995191 (-)
BALB/cJ	MGP_BALBcJ_G0019824	protein coding gene	Chr12:78025294-78123809 (-)
C3H/HeJ	MGP_C3HHeJ_G0019630	protein coding gene	Chr12:80367175-80465025 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0020276	protein coding gene	Chr12:83059463-83159068 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017895	protein coding gene	Chr12:74778950-74869369 (-)
CAST/EiJ	MGP_CASTEiJ_G0019180	protein coding gene	Chr12:75232373-75324220 (-)
CBA/J	MGP_CBAJ_G0019601	protein coding gene	Chr12:86308166-86418445 (-)
DBA/2J	MGP_DBA2J_G0019716	protein coding gene	Chr12:77391154-77486712 (-)
FVB/NJ	MGP_FVBNJ_G0019702	protein coding gene	Chr12:76211126-76309143 (-)
LP/J	MGP_LPJ_G0019788	protein coding gene	Chr12:80623261-80727102 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019741	protein coding gene	Chr12:89331336-89435130 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0020311	protein coding gene	Chr12:79421715-79523749 (-)
PWK/PhJ	MGP_PWKPhJ_G0018946	protein coding gene	Chr12:71785463-71876056 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0018740	protein coding gene	Chr12:73914626-74017956 (-)
WSB/EiJ	MGP_WSBEiJ_G0019233	protein coding gene	Chr12:80054008-80156404 (-)

Human Ortholog

DCAF5, DDB1 and CUL4 associated factor 5

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

DCAF5, DDB1 and CUL4 associated factor 5
Synonyms

BCRG2, BCRP2, D14S1461E, WDR22
Links

HGNC:20224

NCBI Gene ID: 8816

UniProt: Q96JK2
Chr Location

14q24.1; chr14:69050881-69153197 (-) GRCh38

MGI Vertebrate Homology

Dcaf5 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: DCAF5
Gene Tree

Dcaf5

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Phenotype Summary

21 phenotypes from 1 allele in 1 genetic background
9 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Chemically induced (other)

1
Endonuclease-mediated

3
Gene trapped

1
Targeted

3
Genomic Mutations

1 involving Dcaf5
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

26 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

10
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

13
Literature Summary

1

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase dcaf5

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All Sequences

50
RefSeq

4
UniProt

2
CCDS

CCDS26013.1

Ensembl

ENSMUSG00000049106 (Evidence)
NCBI Gene

320808

			Length	Strain/Species	Flank
genomic	320808	NCBI Gene Model \| MGI Sequence Detail	100754	C57BL/6J	± kb
transcript	NM_177267	RefSeq \| MGI Sequence Detail	5706	C57BL/6
polypeptide	Q80T85	UniProt \| EBI \| MGI Sequence Detail	946	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000031463 DDB1- and CUL4-associated factor 5

(term hierarchy)
InterPro Domains

IPR045151 DDB1- and CUL4-associated factor 8-like

IPR001680 WD40 repeat

IPR036322 WD40-repeat-containing domain superfamily

IPR015943 WD40/YVTN repeat-like-containing domain superfamily
GlyGen

Q80T85 1 site

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All nucleic 13

cDNA 13

Microarray probesets 6

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MGI:2144792, MGI:2144823, MGI:2144898, MGI:2145009

Summaries

All 41

Developmental Gene Expression 1

Gene Ontology 7

Phenotypes 9
Earliest

J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
Latest

J:361853 Radko-Juettner S, et al., Targeting DCAF5 suppresses SMARCB1-mutant cancer by stabilizing SWI/SNF. Nature. 2024 Apr;628(8007):442-449

TSS for Dcaf5:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr116886	Chr12:80483566-80483599 (-)	-208 bp
Tssr116885	Chr12:80483345-80483377 (-)	14 bp
Tssr116884	Chr12:80483315-80483340 (-)	47 bp
Tssr116883	Chr12:80483181-80483230 (-)	169 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 03/25/2025 MGI 6.24