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Dcaf5 Gene Detail
Summary
  • Symbol
    Dcaf5
  • Name
    DDB1 and CUL4 associated factor 5
  • Synonyms
    9430020B07Rik, BCRG2, BCRP2, mKIAA1824, Wdr22
  • Feature Type
    protein coding gene
  • IDs
    MGI:2444785
    NCBI Gene: 320808
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:80335848-80436601 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 12, 36.61 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    419 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2444785
protein coding gene Chr12:80335847-80436601 (-)
129S1/SvImJ MGP_129S1SvImJ_G0019887
protein coding gene Chr12:80695205-80796623 (-)
A/J MGP_AJ_G0019845
protein coding gene Chr12:77777067-77871323 (-)
AKR/J MGP_AKRJ_G0019820
protein coding gene Chr12:79891602-79995191 (-)
BALB/cJ MGP_BALBcJ_G0019824
protein coding gene Chr12:78025294-78123809 (-)
C3H/HeJ MGP_C3HHeJ_G0019630
protein coding gene Chr12:80367175-80465025 (-)
C57BL/6NJ MGP_C57BL6NJ_G0020276
protein coding gene Chr12:83059463-83159068 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017895
protein coding gene Chr12:74778950-74869369 (-)
CAST/EiJ MGP_CASTEiJ_G0019180
protein coding gene Chr12:75232373-75324220 (-)
CBA/J MGP_CBAJ_G0019601
protein coding gene Chr12:86308166-86418445 (-)
DBA/2J MGP_DBA2J_G0019716
protein coding gene Chr12:77391154-77486712 (-)
FVB/NJ MGP_FVBNJ_G0019702
protein coding gene Chr12:76211126-76309143 (-)
LP/J MGP_LPJ_G0019788
protein coding gene Chr12:80623261-80727102 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0019741
protein coding gene Chr12:89331336-89435130 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0020311
protein coding gene Chr12:79421715-79523749 (-)
PWK/PhJ MGP_PWKPhJ_G0018946
protein coding gene Chr12:71785463-71876056 (-)
SPRET/EiJ MGP_SPRETEiJ_G0018740
protein coding gene Chr12:73914626-74017956 (-)
WSB/EiJ MGP_WSBEiJ_G0019233
protein coding gene Chr12:80054008-80156404 (-)



Homology
more
  • Human Ortholog
    DCAF5, DDB1 and CUL4 associated factor 5
  • Vertebrate Orthologs
    10
  • Human Ortholog
    DCAF5, DDB1 and CUL4 associated factor 5
    Orthology source: HomoloGene, HGNC
  • Synonyms
    BCRG2, BCRP2, D14S1461E, WDR22
  • Links
    NCBI Gene ID: 8816
    neXtProt AC: NX_Q96JK2
    UniProt: Q96JK2

  • Chr Location
    14q24.1; chr14:69050920-69153393 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 18564
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: DCAF5
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000049106 Ensembl Gene Model | MGI Sequence Detail 100754 C57BL/6J ±  kb
transcript ENSMUST00000054145 Ensembl | MGI Sequence Detail 5706 Not Applicable  
polypeptide ENSMUSP00000052755 Ensembl | MGI Sequence Detail 946 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 13
    cDNA 13

    Microarray probesets 6
Other
Accession IDs
less
MGI:2144792, MGI:2144823, MGI:2144898, MGI:2145009
References
more
  • Summaries
    All 31
    Gene Ontology 2
    Phenotypes 5
  • Earliest
    J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
  • Latest
    J:265473 Leng F, et al., Methylated DNMT1 and E2F1 are targeted for proteolysis by L3MBTL3 and CRL4(DCAF5) ubiquitin ligase. Nat Commun. 2018 Apr 24;9(1):1641

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
08/13/2019
MGI 6.14
The Jackson Laboratory