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Gfm2 Gene Detail
Summary
  • Symbol
    Gfm2
  • Name
    G elongation factor, mitochondrial 2
  • Synonyms
    6530419G12Rik, A930009M04Rik, EFG2, MST027
  • Feature Type
    protein coding gene
  • IDs
    MGI:2444783
    NCBI Gene: 320806
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:97274445-97317703 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 13, 50.66 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    273 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2444783
protein coding gene Chr13:97274445-97317710 (+)
129S1/SvImJ MGP_129S1SvImJ_G0020858
protein coding gene Chr13:98734546-98781492 (+)
A/J MGP_AJ_G0020812
protein coding gene Chr13:95000511-95043501 (+)
AKR/J MGP_AKRJ_G0020786
protein coding gene Chr13:97893283-97944756 (+)
BALB/cJ MGP_BALBcJ_G0020809
protein coding gene Chr13:95684232-95728205 (+)
C3H/HeJ MGP_C3HHeJ_G0020601
protein coding gene Chr13:97618954-97665365 (+)
C57BL/6NJ MGP_C57BL6NJ_G0021244
protein coding gene Chr13:101712616-101759765 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0018814
protein coding gene Chr13:90762804-90807709 (+)
CAST/EiJ MGP_CASTEiJ_G0020120
protein coding gene Chr13:96928636-96974911 (+)
CBA/J MGP_CBAJ_G0020561
protein coding gene Chr13:105773668-105822434 (+)
DBA/2J MGP_DBA2J_G0020686
protein coding gene Chr13:94753070-94796465 (+)
FVB/NJ MGP_FVBNJ_G0020667
protein coding gene Chr13:93520443-93564328 (+)
LP/J MGP_LPJ_G0020761
protein coding gene Chr13:98844320-98890507 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0020695
protein coding gene Chr13:106116770-106164497 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0021285
protein coding gene Chr13:97317929-97362400 (+)
PWK/PhJ MGP_PWKPhJ_G0019872
protein coding gene Chr13:93533107-93578313 (+)
SPRET/EiJ MGP_SPRETEiJ_G0019696
protein coding gene Chr13:93599793-93643716 (+)
WSB/EiJ MGP_WSBEiJ_G0020177
protein coding gene Chr13:97771929-97819085 (+)



Homology
more
  • Human Ortholog
    GFM2, GTP dependent ribosome recycling factor mitochondrial 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GFM2, GTP dependent ribosome recycling factor mitochondrial 2
  • Synonyms
    EFG2, EF-G2mt, hEFG2, mEF-G 2, MRRF2, MST027, MSTP027, RRF, RRF2, RRF2mt
  • Links
    NCBI Gene ID: 84340
    neXtProt AC: NX_Q969S9
    UniProt: Q969S9

  • Chr Location
    5q13.3; chr5:74721204-74767371 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human GFM2 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000021666 Ensembl Gene Model | MGI Sequence Detail 43259 C57BL/6J ±  kb
    transcript ENSMUST00000161639 Ensembl | MGI Sequence Detail 3157 Not Applicable  
    polypeptide ENSMUSP00000125656 Ensembl | MGI Sequence Detail 779 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      8 Sequences
    • Protein Ontology
      PR:000007944 elongation factor G 2, mitochondrial
    • InterPro Domains
      IPR035647 EF-G domain III/V-like
      IPR035649 EFG, domain V
      IPR000640 Elongation factor EFG, domain V-like
      IPR041095 Elongation Factor G, domain II
      IPR009022 Elongation factor G, domain III
      IPR027417 P-loop containing nucleoside triphosphate hydrolase
      IPR020568 Ribosomal protein S5 domain 2-type fold
      IPR014721 Ribosomal protein S5 domain 2-type fold, subgroup
      IPR030851 Ribosome-releasing factor 2, mitochondrial
      IPR005225 Small GTP-binding protein domain
      IPR000795 Translational (tr)-type GTP-binding domain
      IPR005517 Translation elongation factor EFG/EF2, domain IV
      IPR009000 Translation protein, beta-barrel domain superfamily
      IPR031157 Tr-type G domain, conserved site
    Molecular
    Reagents
    less
    • All nucleic 71
      cDNA 71

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:1925484
    References
    more
    • Summaries
      All 29
      Developmental Gene Expression 1
      Gene Ontology 5
      Phenotypes 6
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:265628 Gaudet P, et al., Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief Bioinform. 2011 Sep;12(5):449-62

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    last database update
    07/20/2021
    MGI 6.17
    The Jackson Laboratory