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Tfcp2l1 Gene Detail
Summary
  • Symbol
    Tfcp2l1
  • Name
    transcription factor CP2-like 1
  • Synonyms
    1810030F05Rik, 4932442M07Rik, Cp2l1, Crtr-1, D930018N21Rik, LBP-9, Tcfcp2l1
  • Feature Type
    protein coding gene
  • IDs
    MGI:2444691
    NCBI Gene: 81879
Location & Maps
more
  • Sequence Map
    Chr1:118627945-118685168 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      57224 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 52.14 cM, cytoband E2
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    TFCP2L1, transcription factor CP2-like 1
  • Vertebrate Orthologs
    8
  • Human Ortholog
    TFCP2L1, transcription factor CP2-like 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CRTR1, LBP9, LBP-9
  • Links
    NCBI Gene ID: 29842
    neXtProt AC: NX_Q9NZI6

  • Chr Location
    2q14; chr2:121216587-121285209 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    19 phenotypes from 2 alleles in 3 genetic backgrounds
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    121
  • Chemically induced (other)
    2
  • Gene trapped
    115
  • Radiation induced
    1
  • Targeted
    3
  • Genomic Mutations
    3 involving Tfcp2l1
  • Incidental Mutations
    APF
Mice homozygous for either a knock-out or a gene-trapped allele display a phenotype characterized by postnatal growth retardation, renal hypoplasia, impaired maturation of the ducts in the salivary gland and kidney, abnormal composition of saliva and urine, and postnatal lethality.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000049007 VEGA Gene Model | MGI Sequence Detail 57224 C57BL/6J ±  kb
transcript OTTMUST00000125185 VEGA | MGI Sequence Detail 9269 Not Applicable  
polypeptide OTTMUSP00000067925 VEGA | MGI Sequence Detail 479 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    320 from dbSNP Build 142
Protein
Information
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  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000030552 transcription factor CP2-like protein 1
  • InterPro Domains
    IPR007604 CP2 transcription factor
    IPR013761 Sterile alpha motif/pointed domain
Molecular
Reagents
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  • All nucleic 85
    Genomic 1
    cDNA 81
    Primer pair 2
    Other 1

    Microarray probesets 6
Other
Accession IDs
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MGI:1916402, MGI:1921686, MGI:1932302, MGI:2138114
References
more
  • Summaries
    All 53
    Developmental Gene Expression 13
    Gene Ontology 5
    Phenotypes 15
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:229520 Maruyama EO, et al., Cell-Specific Cre Strains For Genetic Manipulation in Salivary Glands. PLoS One. 2016;11(1):e0146711

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory