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Sptlc3 Gene Detail
Summary
  • Symbol
    Sptlc3
  • Name
    serine palmitoyltransferase, long chain base subunit 3
  • Synonyms
    C130053K05Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2444678
    NCBI Gene: 228677
Location & Maps
more
  • Sequence Map
    Chr2:139493913-139637674 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      143762 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 68.52 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    SPTLC3, serine palmitoyltransferase long chain base subunit 3
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SPTLC3, serine palmitoyltransferase long chain base subunit 3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    C20orf38, dJ718P11, dJ718P11.1, hLCB2b, LCB2B, LCB3, SPT3, SPTLC2L
  • Links
    NCBI Gene ID: 55304
    neXtProt AC: NX_Q9NUV7

  • Chr Location
    chr20:13008979-13170944 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotype references
  • All Mutations and Alleles
    3
  • Chemically induced (other)
    1
  • Radiation induced
    1
  • Targeted
    1
  • Genomic Mutations
    2 involving Sptlc3
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000015585 VEGA Gene Model | MGI Sequence Detail 143762 C57BL/6J ±  kb
transcript OTTMUST00000037017 VEGA | MGI Sequence Detail 2227 Not Applicable  
polypeptide OTTMUSP00000016606 VEGA | MGI Sequence Detail 563 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    656 from dbSNP Build 142
Protein
Information
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  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000015598 serine palmitoyltransferase 3
  • EC
  • InterPro Domains
    IPR004839 Aminotransferase, class I/classII
    IPR001917 Aminotransferase, class-II, pyridoxal-phosphate binding site
    IPR015424 Pyridoxal phosphate-dependent transferase
    IPR015421 Pyridoxal phosphate-dependent transferase, major region, subdomain 1
    IPR015422 Pyridoxal phosphate-dependent transferase, major region, subdomain 2
Molecular
Reagents
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  • All nucleic 8
    cDNA 8

    Microarray probesets 4
References
more
  • Summaries
    All 24
    Developmental Gene Expression 4
    Gene Ontology 3
    Phenotypes 5
  • Earliest
    J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
  • Latest
    J:216600 Lau CG, et al., Morphology-based mammalian stem cell tests reveal potential developmental toxicity of donepezil. Mol Reprod Dev. 2014 Nov;81(11):994-1008

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
09/20/2016
MGI 6.05
The Jackson Laboratory