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Fnip1 Gene Detail
Summary
  • Symbol
    Fnip1
  • Name
    folliculin interacting protein 1
  • Synonyms
    A730024A03Rik, mKIAA1961
  • Feature Type
    protein coding gene
  • IDs
    MGI:2444668
    NCBI Gene: 216742
  • Alliance
  • Transcription Start Sites
    12 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:54329025-54409061 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 11, 32.13 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    155 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2444668
protein coding gene Chr11:54328071-54409067 (+)
129S1/SvImJ MGP_129S1SvImJ_G0018316
protein coding gene Chr11:53911801-53996347 (+)
A/J MGP_AJ_G0018285
protein coding gene Chr11:51900240-51981414 (+)
AKR/J MGP_AKRJ_G0018254
protein coding gene Chr11:53603530-53686889 (+)
BALB/cJ MGP_BALBcJ_G0018256
protein coding gene Chr11:52242914-52323975 (+)
C3H/HeJ MGP_C3HHeJ_G0018067
protein coding gene Chr11:53537021-53617343 (+)
C57BL/6NJ MGP_C57BL6NJ_G0018708
protein coding gene Chr11:55565816-55656083 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0016358
protein coding gene Chr11:49345821-49425927 (+)
CAST/EiJ MGP_CASTEiJ_G0017632
protein coding gene Chr11:53584744-53668487 (+)
CBA/J MGP_CBAJ_G0018042
protein coding gene Chr11:58199013-58282026 (+)
DBA/2J MGP_DBA2J_G0018151
protein coding gene Chr11:51612092-51692260 (+)
FVB/NJ MGP_FVBNJ_G0018143
protein coding gene Chr11:51259766-51339558 (+)
LP/J MGP_LPJ_G0018226
protein coding gene Chr11:54364057-54449311 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0018169
protein coding gene Chr11:59396695-59508147 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0018750
protein coding gene Chr11:53612625-53695730 (+)
PWK/PhJ MGP_PWKPhJ_G0017405
protein coding gene Chr11:52151023-52232231 (+)
SPRET/EiJ MGP_SPRETEiJ_G0017200
protein coding gene Chr11:53391312-53478485 (+)
WSB/EiJ MGP_WSBEiJ_G0017680
protein coding gene Chr11:53248124-53334980 (+)



Homology
more
  • Human Ortholog
    FNIP1, folliculin interacting protein 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FNIP1, folliculin interacting protein 1
  • Synonyms
    IMD93
  • Links
    NCBI Gene ID: 96459
    neXtProt AC: NX_Q8TF40
    UniProt: Q8TF40

  • Chr Location
    5q31.1; chr5:131641714-131797017 (-)  GRCh38

Human Diseases
more
  • Diseases
    1 with human FNIP1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    43 phenotypes from 8 alleles in 10 genetic backgrounds
    14 phenotypes from multigenic genotypes
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for an ENU-induced or targeted allele exhibit arrested B cell development at the pre-B cell stage with increased B cell apoptosis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • cDNA Data
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000035992 Ensembl Gene Model | MGI Sequence Detail 80037 C57BL/6J ±  kb
    transcript ENSMUST00000046835 Ensembl | MGI Sequence Detail 6255 Not Applicable  
    polypeptide ENSMUSP00000049026 Ensembl | MGI Sequence Detail 1165 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000007589 folliculin-interacting protein 1
    • PDB
    • InterPro Domains
      IPR028086 Folliculin-interacting protein, C-terminal domain
      IPR026156 Folliculin-interacting protein family
      IPR028085 Folliculin-interacting protein, middle domain
      IPR028084 Folliculin-interacting protein, N-terminal domain
      IPR037545 Tripartite DENN domain, FNIP1/2-type
    Molecular
    Reagents
    less
    • All nucleic 61
      cDNA 61

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGI:2144273, MGI:2144575
    References
    more
    • Summaries
      All 49
      Diseases 1
      Gene Ontology 7
      Phenotypes 19
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:338230 Manford AG, et al., Structural basis and regulation of the reductive stress response. Cell. 2021 Oct 14;184(21):5375-5390.e16

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    last database update
    03/12/2024
    MGI 6.23
    The Jackson Laboratory