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Fnip1 Gene Detail
Summary
  • Symbol
    Fnip1
  • Name
    folliculin interacting protein 1
  • Synonyms
    A730024A03Rik, mKIAA1961
  • Feature Type
    protein coding gene
  • IDs
    MGI:2444668
    NCBI Gene: 216742
  • Alliance
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:54438199-54518235 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 32.13 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    155 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2444668
protein coding gene Chr11:54438145-54518241 (.)
129S1/SvImJ MGP_129S1SvImJ_G0018316
protein coding gene Chr11:53911801-53996347 (+)
A/J MGP_AJ_G0018285
protein coding gene Chr11:51900240-51981414 (+)
AKR/J MGP_AKRJ_G0018254
protein coding gene Chr11:53603530-53686889 (+)
BALB/cJ MGP_BALBcJ_G0018256
protein coding gene Chr11:52242914-52323975 (+)
C3H/HeJ MGP_C3HHeJ_G0018067
protein coding gene Chr11:53537021-53617343 (+)
C57BL/6NJ MGP_C57BL6NJ_G0018708
protein coding gene Chr11:55565816-55656083 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0016358
protein coding gene Chr11:49345821-49425927 (+)
CAST/EiJ MGP_CASTEiJ_G0017632
protein coding gene Chr11:53584744-53668487 (+)
CBA/J MGP_CBAJ_G0018042
protein coding gene Chr11:58199013-58282026 (+)
DBA/2J MGP_DBA2J_G0018151
protein coding gene Chr11:51612092-51692260 (+)
FVB/NJ MGP_FVBNJ_G0018143
protein coding gene Chr11:51259766-51339558 (+)
LP/J MGP_LPJ_G0018226
protein coding gene Chr11:54364057-54449311 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0018169
protein coding gene Chr11:59396695-59508147 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0018750
protein coding gene Chr11:53612625-53695730 (+)
PWK/PhJ MGP_PWKPhJ_G0017405
protein coding gene Chr11:52151023-52232231 (+)
SPRET/EiJ MGP_SPRETEiJ_G0017200
protein coding gene Chr11:53391312-53478485 (+)
WSB/EiJ MGP_WSBEiJ_G0017680
protein coding gene Chr11:53248124-53334980 (+)



Homology
more
  • Human Ortholog
    FNIP1, folliculin interacting protein 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    FNIP1, folliculin interacting protein 1
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 96459
    neXtProt AC: NX_Q8TF40
    UniProt: Q8TF40

  • Chr Location
    5q31.1; chr5:131641714-131797063 (-)  GRCh38.p7

Human Diseases
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  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    41 phenotypes from 6 alleles in 8 genetic backgrounds
    14 phenotypes from multigenic genotypes
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for an ENU-induced or targeted allele exhibit arrested B cell development at the pre-B cell stage with increased B cell apoptosis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000035992 Ensembl Gene Model | MGI Sequence Detail 80037 C57BL/6J ±  kb
transcript ENSMUST00000046835 Ensembl | MGI Sequence Detail 6255 Not Applicable  
polypeptide ENSMUSP00000049026 Ensembl | MGI Sequence Detail 1165 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000007589 folliculin-interacting protein 1
  • InterPro Domains
    IPR028086 Folliculin-interacting protein, C-terminal domain
    IPR026156 Folliculin-interacting protein family
    IPR028085 Folliculin-interacting protein, middle domain
    IPR028084 Folliculin-interacting protein, N-terminal domain
    IPR037545 Tripartite DENN domain, FNIP1/2-type
Molecular
Reagents
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  • All nucleic 61
    cDNA 61

    Microarray probesets 7
Other
Accession IDs
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MGI:2144273, MGI:2144575
References
more
  • Summaries
    All 38
    Diseases 1
    Gene Ontology 5
    Phenotypes 14
  • Earliest
    J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
  • Latest
    J:262829 Centini R, et al., Loss of Fnip1 alters kidney developmental transcriptional program and synergizes with TSC1 loss to promote mTORC1 activation and renal cyst formation. PLoS One. 2018;13(6):e0197973

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory