Sh3rf3 MGI Mouse Gene Detail - MGI:2444637 - SH3 domain containing ring finger 3

Symbol

Sh3rf3
Name

SH3 domain containing ring finger 3
Synonyms

4831416G18Rik, Sh3md4

Feature Type

protein coding gene
IDs

MGI:2444637
NCBI Gene: 237353
Alliance

gene page
Transcription Start Sites

11 TSS

Sequence Map

Chr10:58649181-58974738 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 29.41 cM
Mapping Data

1 experiment

SNPs within 2kb

10507 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2444637	protein coding gene	Chr10:58649181-58974738 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0017252	protein coding gene	Chr10:57947077-58281459 (+)
A/J	MGP_AJ_G0017229	protein coding gene	Chr10:56261028-56586734 (+)
AKR/J	MGP_AKRJ_G0017188	protein coding gene	Chr10:57723880-58047946 (+)
BALB/cJ	MGP_BALBcJ_G0017190	protein coding gene	Chr10:56336583-56659056 (+)
C3H/HeJ	MGP_C3HHeJ_G0017013	protein coding gene	Chr10:57630764-57976014 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0017648	protein coding gene	Chr10:60037995-60382143 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015339	protein coding gene	Chr10:53322559-53637824 (+)
CAST/EiJ	MGP_CASTEiJ_G0016584	protein coding gene	Chr10:57539065-57887720 (+)
CBA/J	MGP_CBAJ_G0016985	protein coding gene	Chr10:62195625-62534667 (+)
DBA/2J	MGP_DBA2J_G0017090	protein coding gene	Chr10:55579084-55902799 (+)
FVB/NJ	MGP_FVBNJ_G0017084	protein coding gene	Chr10:54816698-55132513 (+)
LP/J	MGP_LPJ_G0017165	protein coding gene	Chr10:58337851-58672034 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0017112	protein coding gene	Chr10:64721959-65073629 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0017685	protein coding gene	Chr10:57529505-57857760 (+)
PWK/PhJ	MGP_PWKPhJ_G0016367	protein coding gene	Chr10:55367458-55699273 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0016150	protein coding gene	Chr10:56881987-57214909 (+)
WSB/EiJ	MGP_WSBEiJ_G0016648	protein coding gene	Chr10:57410816-57753910 (+)

Human Ortholog

SH3RF3, SH3 domain containing ring finger 3

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SH3RF3, SH3 domain containing ring finger 3
Synonyms

POSH2, SH3MD4
Links

HGNC:24699

NCBI Gene ID: 344558

UniProt: Q8TEJ3
Chr Location

2q13; chr2:109129205-109504634 (+) GRCh38

MGI Vertebrate Homology

Sh3rf3 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: SH3RF3
Gene Tree

Sh3rf3

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
12 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Chemically induced (other)

1
Endonuclease-mediated

3
Gene trapped

1
Radiation induced

1
Targeted

1
Genomic Mutations

2 involving Sh3rf3
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

49 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

16
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

800
Tissues

12
cDNA Data

6
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase sh3rf3

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All Sequences

42
RefSeq

4
UniProt

2
CCDS

CCDS35906.2

Ensembl

ENSMUSG00000037990 (Evidence)
NCBI Gene

237353

			Length	Strain/Species	Flank
genomic	237353	NCBI Gene Model \| MGI Sequence Detail	325558	C57BL/6J	± kb
transcript	NM_172788	RefSeq \| MGI Sequence Detail	5796	C57BL/6
polypeptide	Q8C120	UniProt \| EBI \| MGI Sequence Detail	878	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000029752 E3 ubiquitin-protein ligase SH3RF3

(term hierarchy)
EC

2.3.2.27
InterPro Domains

IPR028502 E3 ubiquitin-protein ligase SH3RF3, RING finger, HC subclass

IPR050384 Endophilin/SH3RF

IPR001452 SH3 domain

IPR036028 SH3-like domain superfamily

IPR035816 SH3RF1/SH3RF3, fourth SH3 domain

IPR035612 SH3RF3, SH3 domain 3

IPR013083 Zinc finger, RING/FYVE/PHD-type

IPR001841 Zinc finger, RING-type

IPR017907 Zinc finger, RING-type, conserved site

IPR027370 Zinc finger, RING-type, eukaryotic
GlyGen

Q8C120 8 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (4 sites)

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All nucleic 6

cDNA 6

Microarray probesets 3

Summaries

All 35

Developmental Gene Expression 2

Gene Ontology 6

Phenotypes 12
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Sh3rf3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr93462	Chr10:58648159-58648174 (+)	-1,014 bp
Tssr93463	Chr10:58648181-58648231 (+)	-975 bp
Tssr93464	Chr10:58648297-58648317 (+)	-874 bp
Tssr93465	Chr10:58648388-58648422 (+)	-776 bp
Tssr93466	Chr10:58660285-58660292 (+)	11,108 bp
Tssr93467	Chr10:58663041-58663045 (+)	13,862 bp
Tssr93468	Chr10:58852188-58852191 (+)	203,009 bp
Tssr93469	Chr10:58921587-58921591 (+)	272,408 bp
Tssr93470	Chr10:58972690-58972715 (+)	323,522 bp
Tssr3208	Chr10:58972799-58972811 (+)	323,624 bp
Tssr93471	Chr10:58972819-58972835 (+)	323,646 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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