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Clec9a Gene Detail
Summary
  • Symbol
    Clec9a
  • Name
    C-type lectin domain family 9, member a
  • Synonyms
    9830005G06Rik, DNGR-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:2444608
    NCBI Gene: 232414
  • Gene Overview
    MyGene.info: CLEC9A
Location & Maps
more
  • Sequence Map
    Chr6:129408862-129424763 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      15902 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 63.30 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    CLEC9A, C-type lectin domain family 9 member A
  • Vertebrate Orthologs
    7
  • Human Ortholog
    CLEC9A, C-type lectin domain family 9 member A
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CD370, DNGR1, DNGR-1, UNQ9341
  • Links
    NCBI Gene ID: 283420
    neXtProt AC: NX_Q6UXN8

  • Chr Location
    12p13.2; chr12:10030677-10066030 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotypes from 3 alleles in 3 genetic backgrounds
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice have CD8alpha+ dendritic cells that are defective in cross-presentation of dead-cell associated antigens.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000027008 VEGA Gene Model | MGI Sequence Detail 15902 C57BL/6J ±  kb
transcript OTTMUST00000066748 VEGA | MGI Sequence Detail 3293 Not Applicable  
polypeptide OTTMUSP00000033497 VEGA | MGI Sequence Detail 264 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    835 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 5
    cDNA 5

    Microarray probesets 1
References
more
  • Summaries
    All 35
    Gene Ontology 4
    Phenotypes 16
  • Earliest
    J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
  • Latest
    J:230701 van Blijswijk J, et al., Altered lymph node composition in diphtheria toxin receptor-based mouse models to ablate dendritic cells. J Immunol. 2015 Jan 1;194(1):307-15

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory