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Clec9a Gene Detail
Summary
  • Symbol
    Clec9a
  • Name
    C-type lectin domain family 9, member a
  • Synonyms
    9830005G06Rik, DNGR-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:2444608
    NCBI Gene: 232414
  • Gene Overview
    MyGene.info: CLEC9A
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:129408862-129424763 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 63.30 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    835 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2444608
protein coding gene Chr6:129408862-129424764 (.)
129S1/SvImJ MGP_129S1SvImJ_G0031347
protein coding gene Chr6:133079335-133096021 (+)
A/J MGP_AJ_G0031318
protein coding gene Chr6:127983527-128000031 (+)
AKR/J MGP_AKRJ_G0031246
protein coding gene Chr6:131482004-131500059 (+)
BALB/cJ MGP_BALBcJ_G0031325
protein coding gene Chr6:127631487-127647232 (+)
C3H/HeJ MGP_C3HHeJ_G0031049
protein coding gene Chr6:131677669-131693484 (+)
C57BL/6NJ MGP_C57BL6NJ_G0031784
protein coding gene Chr6:136575253-136590993 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028930
protein coding gene Chr6:126307489-126325823 (+)
CAST/EiJ MGP_CASTEiJ_G0030427
protein coding gene Chr6:131910034-131927460 (+)
CBA/J MGP_CBAJ_G0031009
protein coding gene Chr6:141952490-141968254 (+)
DBA/2J MGP_DBA2J_G0031166
protein coding gene Chr6:126936857-126952642 (+)
FVB/NJ MGP_FVBNJ_G0031116
protein coding gene Chr6:125819731-125835461 (+)
LP/J MGP_LPJ_G0031246
protein coding gene Chr6:133296490-133313557 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0031154
protein coding gene Chr6:145794651-145811189 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0031817
protein coding gene Chr6:131544772-131560597 (+)
PWK/PhJ MGP_PWKPhJ_G0030145
protein coding gene Chr6:125216344-125232375 (+)
SPRET/EiJ MGP_SPRETEiJ_G0029974
protein coding gene Chr6:129564034-129580823 (+)
WSB/EiJ MGP_WSBEiJ_G0030515
protein coding gene Chr6:131968943-131985263 (+)



Homology
more
  • Human Ortholog
    CLEC9A, C-type lectin domain containing 9A
  • Vertebrate Orthologs
    7
  • Human Ortholog
    CLEC9A, C-type lectin domain containing 9A
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CD370, DNGR1, DNGR-1, UNQ9341
  • Links
    NCBI Gene ID: 283420
    neXtProt AC: NX_Q6UXN8
    UniProt: Q6UXN8

  • Chr Location
    12p13.2; chr12:10030677-10066030 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 3 alleles in 3 genetic backgrounds
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null mice have CD8alpha+ dendritic cells that are defective in cross-presentation of dead-cell associated antigens.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000046080 Ensembl Gene Model | MGI Sequence Detail 15902 C57BL/6J ±  kb
transcript ENSMUST00000058352 Ensembl | MGI Sequence Detail 3293 Not Applicable  
polypeptide ENSMUSP00000056625 Ensembl | MGI Sequence Detail 264 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 6
    cDNA 6

    Microarray probesets 1
References
more
  • Summaries
    All 42
    Gene Ontology 6
    Phenotypes 18
  • Earliest
    J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
  • Latest
    J:257678 Kedl RM, et al., Migratory dendritic cells acquire and present lymphatic endothelial cell-archived antigens during lymph node contraction. Nat Commun. 2017 Dec 11;8(1):2034

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory