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Kif20b Gene Detail
Summary
  • Symbol
    Kif20b
  • Name
    kinesin family member 20B
  • Synonyms
    33cex, C330014J10Rik, Kif20b, magoo, Mphosph1, N-6 kinesin
  • Feature Type
    protein coding gene
  • IDs
    MGI:2444576
    NCBI Gene: 240641
  • Gene Overview
    MyGene.info: KIF20B
Location & Maps
more
  • Sequence Map
    Chr19:34922358-34975731 bp, + strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      53374 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 19, 29.79 cM
  • Mapping Data
    5 experiments
Homology
more
  • Human Ortholog
    KIF20B, kinesin family member 20B
  • Vertebrate Orthologs
    10
  • Human Ortholog
    KIF20B, kinesin family member 20B
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CT90, KRMP1, MPHOSPH1, MPP1, MPP-1
  • Links
    NCBI Gene ID: 9585
    neXtProt AC: NX_Q96Q89

  • Chr Location
    10q23.31; chr10:89701590-89774943 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    27 phenotypes from 2 alleles in 3 genetic backgrounds
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    26
  • Chemically induced (ENU)
    2
  • Gene trapped
    22
  • Targeted
    2
  • Incidental Mutations
Mice homozygous for ENU induced mutations display craniofacial and nervous system abnormalities including exencephaly, microcephaly, decreased forebrain size and impaired neuronal progenitor proliferation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000024795 Ensembl Gene Model | MGI Sequence Detail 53374 C57BL/6J ±  kb
transcript ENSMUST00000087341 Ensembl | MGI Sequence Detail 5563 Not Applicable  
polypeptide ENSMUSP00000084599 Ensembl | MGI Sequence Detail 1774 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    357 from dbSNP Build 142
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000010535 kinesin-like protein KIF20B
  • InterPro Domains
    IPR027640 Kinesin-like protein
    IPR028828 Kinesin-like protein KIF20B
    IPR001752 Kinesin motor domain
    IPR019821 Kinesin motor domain, conserved site
    IPR027417 P-loop containing nucleoside triphosphate hydrolase
Molecular
Reagents
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  • All nucleic 90
    cDNA 90

    Microarray probesets 2
Other
Accession IDs
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MGI:2447029, MGI:3578175, MGI:4889064
References
more
  • Summaries
    All 39
    Developmental Gene Expression 2
    Gene Ontology 8
    Phenotypes 11
  • Earliest
    J:70760 Miki H, et al., All kinesin superfamily protein, KIF, genes in mouse and human. Proc Natl Acad Sci U S A. 2001 Jun 19;98(13):7004-11
  • Latest
    J:205043 Janisch KM, et al., The vertebrate-specific Kinesin-6, Kif20b, is required for normal cytokinesis of polarized cortical stem cells and cerebral cortex size. Development. 2013 Dec;140(23):4672-82

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/15/2016
MGI 6.04
The Jackson Laboratory