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Kif20b Gene Detail
Summary
  • Symbol
    Kif20b
  • Name
    kinesin family member 20B
  • Synonyms
    33cex, C330014J10Rik, Kif20b, magoo, Mphosph1, N-6 kinesin
  • Feature Type
    protein coding gene
  • IDs
    MGI:2444576
    NCBI Gene: 240641
  • Gene Overview
    MyGene.info: KIF20B
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr19:34922361-34975745 bp, + strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      53385 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 19, 29.79 cM
  • Mapping Data
    5 experiments
Homology
more
  • Human Ortholog
    KIF20B, kinesin family member 20B
  • Vertebrate Orthologs
    10
  • Human Ortholog
    KIF20B, kinesin family member 20B
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CT90, KRMP1, MPHOSPH1, MPP1, MPP-1
  • Links
    NCBI Gene ID: 9585
    neXtProt AC: NX_Q96Q89
    UniProt: Q96Q89

  • Chr Location
    10q23.31; chr10:89701590-89774943 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Kif20b mouse models

Human Disease Mouse Models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    35 phenotypes from 2 alleles in 4 genetic backgrounds
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for ENU induced mutations display craniofacial and nervous system abnormalities including exencephaly, microcephaly, decreased forebrain size and impaired neuronal progenitor proliferation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000024795 Ensembl Gene Model | MGI Sequence Detail 53385 C57BL/6J ±  kb
    transcript ENSMUST00000087341 Ensembl | MGI Sequence Detail 5564 Not Applicable  
    polypeptide ENSMUSP00000084599 Ensembl | MGI Sequence Detail 1774 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      357 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 90
      cDNA 90

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGI:2447029, MGI:3578175, MGI:4889064
    References
    more
    • Summaries
      All 40
      Developmental Gene Expression 2
      Diseases 1
      Gene Ontology 8
      Phenotypes 12
    • Earliest
      J:70760 Miki H, et al., All kinesin superfamily protein, KIF, genes in mouse and human. Proc Natl Acad Sci U S A. 2001 Jun 19;98(13):7004-11
    • Latest
      J:242310 McNeely KC, et al., Mutation of Kinesin-6 Kif20b causes defects in cortical neuron polarization and morphogenesis. Neural Dev. 2017 Mar 31;12(1):5

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    05/15/2018
    MGI 6.12
    The Jackson Laboratory