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Tafa4 Gene Detail
Summary
  • Symbol
    Tafa4
  • Name
    TAFA chemokine like family member 4
  • Synonyms
    C130034I18Rik, Fam19a4, Tafa4
  • Feature Type
    protein coding gene
  • IDs
    MGI:2444563
    NCBI Gene: 320701
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:96808164-97037374 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 44.80 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    1075 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2444563
protein coding gene Chr6:96808164-97037452 (-)
129S1/SvImJ MGP_129S1SvImJ_G0031071
protein coding gene Chr6:98648825-98886756 (-)
A/J MGP_AJ_G0031040
protein coding gene Chr6:94917395-95145132 (-)
AKR/J MGP_AKRJ_G0030971
protein coding gene Chr6:97542507-97772831 (-)
BALB/cJ MGP_BALBcJ_G0031051
protein coding gene Chr6:94867909-95094704 (-)
C3H/HeJ MGP_C3HHeJ_G0030657
protein coding gene Chr6:86673521-86888832 (+)
C57BL/6NJ MGP_C57BL6NJ_G0031510
protein coding gene Chr6:101145668-101387037 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028675
protein coding gene Chr6:92787882-92968746 (-)
CAST/EiJ MGP_CASTEiJ_G0030158
protein coding gene Chr6:97719808-97936742 (-)
CBA/J MGP_CBAJ_G0030737
protein coding gene Chr6:104971453-105241662 (-)
DBA/2J MGP_DBA2J_G0030890
protein coding gene Chr6:94051635-94288626 (-)
FVB/NJ MGP_FVBNJ_G0030844
protein coding gene Chr6:93238351-93466295 (-)
LP/J MGP_LPJ_G0030970
protein coding gene Chr6:98668667-98901010 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030878
protein coding gene Chr6:108938455-109177454 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0031537
protein coding gene Chr6:97410562-97630881 (-)
PWK/PhJ MGP_PWKPhJ_G0029874
protein coding gene Chr6:93056074-93267665 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029702
protein coding gene Chr6:96308962-96540069 (-)
WSB/EiJ MGP_WSBEiJ_G0030242
protein coding gene Chr6:97860156-98090595 (-)



Homology
more
  • Human Ortholog
    TAFA4, TAFA chemokine like family member 4
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TAFA4, TAFA chemokine like family member 4
  • Synonyms
    FAM19A4, TAFA-4
  • Links
    NCBI Gene ID: 151647
    neXtProt AC: NX_Q96LR4
    UniProt: Q96LR4

  • Chr Location
    3p14.1; chr3:68731764-68932610 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 2 alleles in 2 genetic backgrounds
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit increased mechanical and chemical nociception following inflammation or injury due to alterations in lamina IIi neuron excitability.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000046500 Ensembl Gene Model | MGI Sequence Detail 229211 C57BL/6J ±  kb
    transcript ENSMUST00000089295 Ensembl | MGI Sequence Detail 2190 Not Applicable  
    polypeptide ENSMUSP00000086710 Ensembl | MGI Sequence Detail 135 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 6
      cDNA 6

      Microarray probesets 2
    References
    more
    • Summaries
      All 40
      Developmental Gene Expression 4
      Gene Ontology 5
      Phenotypes 15
    • Earliest
      J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
    • Latest
      J:324662 Yoo S, et al., TAFA4 relieves injury-induced mechanical hypersensitivity through LDL receptors and modulation of spinal A-type K(+) current. Cell Rep. 2021 Oct 26;37(4):109884

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    last database update
    08/03/2022
    MGI 6.21
    The Jackson Laboratory