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Mapk4
Gene Detail
Symbol

Name
ID
Mapk4
mitogen-activated protein kinase 4
MGI:2444559
Synonyms
A330097D03Rik, Erk3-related, p63Mapk
Feature Type
protein coding gene
Genetic Map
Chromosome 18
50.31 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr18:73928486-74065359 bp, - strand
From VEGA annotation of GRCm38

  136874 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2058  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 western clawed frog; 1 zebrafish

Gene Tree: Mapk4

Human
homologs
Human Homolog MAPK4, mitogen-activated protein kinase 4
NCBI Gene ID 5596
neXtProt AC  NX_P31152
Human Synonyms  ERK4, ERK-4, p63MAPK, p63-MAPK, PRKM4
Human Chr (Location)  18q21.1; chr18:50560114-50731826 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(39) : Gene trapped(38) Targeted(1)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Mapk4 interacts with 343 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (19 annotations)
Process cell cycle, phosphorylation, ...
Component cytoplasm, nucleus
Function ATP binding, kinase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (24)    Tissues (15)    Images (2)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 24
cDNA source data(21)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(21) cDNA(21)
Microarray probesets(2)
Other database
links
VEGA Gene ModelOTTMUSG00000033283 (Evidence)
Ensembl Gene ModelENSMUSG00000024558 (Evidence)
Entrez Gene225724 (Evidence)
UniGene254517
DFCITC1583252
DoTSDT.110760515, DT.91333211, DT.94139426
NIA Mouse Gene IndexU038555
EC2.7.11.24
Consensus CDS ProjectCCDS37856.1
International Mouse Knockout Project StatusMapk4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000033283 VEGA Gene Model | MGI Sequence Detail 136874 C57BL/6J ±  kb
transcript OTTMUST00000083480 VEGA | MGI Sequence Detail 4594 Not Applicable 
polypeptide OTTMUSP00000044875 VEGA | MGI Sequence Detail 583 Not Applicable 

For the selected sequences
All sequences(45) RefSeq(8) UniProt(5)
Polymorphisms
SNPs within 2kb(2054 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008350 Mitogen-activated protein (MAP) kinase, ERK3/4
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR002290 Serine/threonine- / dual specificity protein kinase, catalytic domain
InterPro IPR008271 Serine/threonine-protein kinase, active site
Protein Ontology PR:000010157 mitogen-activated protein kinase 4
References
(Earliest) J:37168 Garcia JI, et al., Isolation of a cDNA encoding the rat MAP-kinase homolog of human p63mapk. Mamm Genome. 1996 Nov;7(11):810-4
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(35)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory