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Mapkap1 Gene Detail
Summary
  • Symbol
    Mapkap1
  • Name
    mitogen-activated protein kinase associated protein 1
  • Synonyms
    D230039K05Rik, Sin1
  • Feature Type
    protein coding gene
  • IDs
    MGI:2444554
    NCBI Gene: 227743
  • Gene Overview
    MyGene.info: MAPKAP1
Location & Maps
more
  • Sequence Map
    Chr2:34406771-34624949 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      218179 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 22.84 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    MAPKAP1, mitogen-activated protein kinase associated protein 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    MAPKAP1, mitogen-activated protein kinase associated protein 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    JC310, MIP1, SIN1, SIN1b, SIN1g
  • Links
    NCBI Gene ID: 79109
    neXtProt AC: NX_Q9BPZ7

  • Chr Location
    9q33.3; chr9:125437394-125707234 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    8 phenotypes from 3 alleles in 3 genetic backgrounds
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice exhibit embryonic lethality due to early developmental abnormalities. Mutant mouse embryonic fibroblasts display increased susceptibility to stress-induced apoptosis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000011942 VEGA Gene Model | MGI Sequence Detail 218179 C57BL/6J ±  kb
transcript OTTMUST00000028215 VEGA | MGI Sequence Detail 3111 Not Applicable  
polypeptide OTTMUSP00000012773 VEGA | MGI Sequence Detail 522 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    1224 from dbSNP Build 142
Protein
Information
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  • UniProt
    6 Sequences
  • Protein Ontology
    PR:000010164 target of rapamycin complex 2 subunit MAPKAP1
  • InterPro Domains
    IPR031313 SAPK-interacting protein 1, Pleckstrin-homology domain
    IPR031567 Sin1, middle CRIM domain
    IPR032679 Sin1, N-terminal
    IPR008828 TORC2 component Sin1/Avo1
    IPR001859 Trypanosoma cruzi ribosomal protein P2-like
Molecular
Reagents
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  • All nucleic 15
    cDNA 15

    Microarray probesets 5
Other
Accession IDs
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MGI:2139008
References
more
  • Summaries
    All 53
    Developmental Gene Expression 2
    Gene Ontology 5
    Phenotypes 19
  • Earliest
    J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-le-grand). 1999 Jul;45(5):737-50
  • Latest
    J:220078 Xu Y, et al., DNA-PKcs-SIN1 complexation mediates low-dose X-ray irradiation (LDI)-induced Akt activation and osteoblast differentiation. Biochem Biophys Res Commun. 2014 Oct 24;453(3):362-7

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/15/2016
MGI 6.04
The Jackson Laboratory