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Mapkap1 Gene Detail
Summary
  • Symbol
    Mapkap1
  • Name
    mitogen-activated protein kinase associated protein 1
  • Synonyms
    D230039K05Rik, Sin1
  • Feature Type
    protein coding gene
  • IDs
    MGI:2444554
    NCBI Gene: 227743
  • Alliance
    genome feature page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:34296783-34514962 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 22.84 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    4138 from dbSNP Build 142
  • Strain Annotations
    27
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2444554
 protein coding gene Chr2:34296783-34514970 (+)
129S1/SvImJ ENSMUSGG00200054948
 protein coding gene Chr2:31367002-31492862 (+)
129S1/SvImJ ENSMUSG00200047198
 protein coding gene Chr2:31301295-31301424 (+)
A/J ENSMUSGG00195054923
 protein coding gene Chr2:31469203-31594643 (+)
A/J ENSMUSG00195035882
 protein coding gene Chr2:31403550-31403679 (+)
AKR/J ENSMUSG00220043791
 protein coding gene Chr2:31518470-31518599 (+)
AKR/J ENSMUSGG00220054587
 protein coding gene Chr2:31584125-31709562 (+)
BALB/cJ ENSMUSG00180047293
 protein coding gene Chr2:31417661-31417790 (+)
BALB/cJ ENSMUSGG00180055262
 protein coding gene Chr2:31483367-31609232 (+)
C3H/HeJ ENSMUSG00175040037
 protein coding gene Chr2:31383982-31384111 (+)
C3H/HeJ ENSMUSGG00175054985
 protein coding gene Chr2:31449684-31575558 (+)
C57BL/6NJ ENSMUSG00215046426
 protein coding gene Chr2:31451100-31451229 (+)
C57BL/6NJ ENSMUSGG00215055455
 protein coding gene Chr2:31516805-31642674 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0023465
 protein coding gene Chr2:30306798-30516459 (+)
CAST/EiJ no annotation
CBA/J ENSMUSG00210047796
 protein coding gene Chr2:31456394-31456523 (+)
CBA/J ENSMUSGG00210054792
 protein coding gene Chr2:31522090-31647957 (+)
DBA/2J ENSMUSG00185046257
 protein coding gene Chr2:31316589-31316718 (+)
DBA/2J ENSMUSGG00185057634
 protein coding gene Chr2:31382238-31507666 (+)
FVB/NJ ENSMUSG00205032873
 protein coding gene Chr2:31164278-31164407 (+)
FVB/NJ ENSMUSGG00205054578
 protein coding gene Chr2:31229932-31355382 (+)
JF1/MsJ no annotation
LP/J ENSMUSGG00230055412
 protein coding gene Chr2:33302394-33428258 (+)
LP/J ENSMUSG00230040167
 protein coding gene Chr2:33236692-33236821 (+)
NOD/ShiLtJ ENSMUSG00190036614
 protein coding gene Chr2:31417911-31418040 (+)
NOD/ShiLtJ ENSMUSGG00190054979
 protein coding gene Chr2:31483569-31608984 (+)
NZO/HlLtJ ENSMUSG00225048625
 protein coding gene Chr2:40993708-40993837 (+)
NZO/HlLtJ ENSMUSGG00225055363
 protein coding gene Chr2:41059385-41184887 (+)
PWK/PhJ no annotation
SPRET/EiJ ENSMSPG00010033537
 protein coding gene Chr2:31979355-32195701 (+)
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    MAPKAP1, MAPK associated protein 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MAPKAP1, MAPK associated protein 1
  • Synonyms
    JC310, MIP1, SIN1, SIN1b, SIN1g
  • Links
    NCBI Gene ID: 79109
    UniProt: Q9BPZ7

  • Chr Location
    9q33.3; chr9:125437393-125707266 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 3 alleles in 3 genetic backgrounds
    27 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice exhibit embryonic lethality due to early developmental abnormalities. Mutant mouse embryonic fibroblasts display increased susceptibility to stress-induced apoptosis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    104
  • GO References
    16
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    631
  • Tissues
    20
  • cDNA Data
    16
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000038696 Ensembl Gene Model | MGI Sequence Detail 218180 C57BL/6J ±  kb
    transcript ENSMUST00000113126 Ensembl | MGI Sequence Detail 3018 Not Applicable  
    polypeptide ENSMUSP00000108751 Ensembl | MGI Sequence Detail 522 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      6 Sequences
    • Protein Ontology
      PR:000010164 target of rapamycin complex 2 subunit MAPKAP1
      (term hierarchy)
    • InterPro Domains
      IPR001859 Large ribosomal subunit protein P1/P2, eukaryota
      IPR011993 PH-like domain superfamily
      IPR031313 SAPK-interacting protein 1, Pleckstrin-homology domain
      IPR031567 Sin1, middle CRIM domain
      IPR032679 Sin1, N-terminal
      IPR057339 Target of rapamycin complex 2 subunit MAPKAP1-like, Ras-binding domain
      IPR008828 TORC2 component Sin1/Avo1
    Molecular
    Reagents
    less
    • All nucleic 16
      cDNA 16
      Antibodies 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:2139008
    References
    more
    • Summaries
      All 81
      Developmental Gene Expression 4
      Gene Ontology 16
      Phenotypes 27
    • Earliest
      J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-Le-Grand). 1999 Jul;45(5):737-50
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory