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Mapkap1
Gene Detail
Symbol

Name
ID
Mapkap1
mitogen-activated protein kinase associated protein 1
MGI:2444554
Synonyms
D230039K05Rik, Sin1
Feature Type
protein coding gene
Genetic Map
Chromosome 2
22.84 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr2:34406771-34624949 bp, + strand
From VEGA annotation of GRCm38

  218179 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:11473  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: MAPKAP1
Gene Tree: Mapkap1

Human
homologs
MAPKAP1, mitogen-activated protein kinase associated protein 1
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 79109
neXtProt AC: NX_Q9BPZ7

Human Synonyms: JC310, MIP1, SIN1, SIN1b, SIN1g

Human Chr (Location): 9q33.3; chr9:125437394-125707234 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(22) : Gene trapped(18) Targeted(4)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygous null mice exhibit embryonic lethality due to early developmental abnormalities. Mutant mouse embryonic fibroblasts display increased susceptibility to stress-induced apoptosis.
 
Interactions
Mapkap1 interacts with 214 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (2 records)
cDNA source data(15)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase mapkap1 ; ZFIN mapkap1    NEW 
Molecular
reagents
All nucleic(15) cDNA(15)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000011942 (Evidence)
Ensembl Gene Model ENSMUSG00000038696 (Evidence)
Entrez Gene 227743 (Evidence)
DFCI TC1576149, TC1592313, TC1607047, TC1610287
DoTS DT.110702472, DT.531373, DT.91418259
NIA Mouse Gene Index U001642
Consensus CDS Project CCDS15948.1, CCDS71035.1
International Mouse Phenotyping Consortium Status Mapkap1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000011942 VEGA Gene Model | MGI Sequence Detail 218179 C57BL/6J ±  kb
transcript OTTMUST00000028215 VEGA | MGI Sequence Detail 3111 Not Applicable 
polypeptide OTTMUSP00000012773 VEGA | MGI Sequence Detail 522 Not Applicable 

For the selected sequences
All sequences(96) RefSeq(24) UniProt(6)
Polymorphisms
SNPs within 2kb(1231 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001859 Ribosomal protein P2
InterPro IPR008828 Stress-activated map kinase interacting 1
Protein Ontology PR:000010164 target of rapamycin complex 2 subunit MAPKAP1
References
(Earliest) J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-le-grand). 1999 Jul;45(5):737-50
(Latest) J:208097 Liu P, et al., Sin1 phosphorylation impairs mTORC2 complex integrity and inhibits downstream Akt signalling to suppress tumorigenesis. Nat Cell Biol. 2013 Nov;15(11):1340-50
All references(54)
Other
accession IDs
MGI:2139008

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory