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Mapkap1
Gene Detail
Symbol

Name
ID
Mapkap1
mitogen-activated protein kinase associated protein 1
MGI:2444554
Synonyms
D230039K05Rik, Sin1
Feature Type
protein coding gene
Genetic Map
Chromosome 2
22.84 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr2:34406771-34624949 bp, + strand
From VEGA annotation of GRCm38

  218179 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:11473  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Mapkap1

Human
homologs
Human Homolog MAPKAP1, mitogen-activated protein kinase associated protein 1
NCBI Gene ID 79109
neXtProt AC  NX_Q9BPZ7
Human Synonyms  JC310, MIP1, SIN1, SIN1b, SIN1g
Human Chr (Location)  9q33.3; chr9:125437394-125707234 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(22) : Gene trapped(18) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice exhibit embryonic lethality due to early developmental abnormalities. Mutant mouse embryonic fibroblasts display increased susceptibility to stress-induced apoptosis.
 
Interactions
Mapkap1 interacts with 215 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (2 records)
cDNA source data(15)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(15) cDNA(15)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000011942 (Evidence)
Ensembl Gene ModelENSMUSG00000038696 (Evidence)
Entrez Gene227743 (Evidence)
DFCITC1576149, TC1592313, TC1607047, TC1610287
DoTSDT.91418259, DT.531373, DT.110702472
NIA Mouse Gene IndexU001642
Consensus CDS ProjectCCDS15948.1, CCDS71035.1
International Mouse Knockout Project StatusMapkap1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000011942 VEGA Gene Model | MGI Sequence Detail 218179 C57BL/6J ±  kb
transcript OTTMUST00000028215 VEGA | MGI Sequence Detail 3111 Not Applicable 
polypeptide OTTMUSP00000012773 VEGA | MGI Sequence Detail 522 Not Applicable 

For the selected sequences
All sequences(93) RefSeq(22) UniProt(7)
Polymorphisms
SNPs within 2kb(1231 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001859 Ribosomal protein P2
InterPro IPR008828 Stress-activated map kinase interacting 1
Protein Ontology PR:000010164 target of rapamycin complex 2 subunit MAPKAP1
References
(Earliest) J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-le-grand). 1999 Jul;45(5):737-50
(Latest) J:202161 Larusch GA, et al., Domain 2 of uPAR regulates single-chain urokinase-mediated angiogenesis through beta1-integrin and VEGFR2. Am J Physiol Heart Circ Physiol. 2013 Aug 1;305(3):H305-20
All references(53)
Other
accession IDs
MGI:2139008

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory