Ralgapb MGI Mouse Gene Detail - MGI:2444531 - Ral GTPase activating protein, beta subunit (non-catalytic)

Symbol

Ralgapb
Name

Ral GTPase activating protein, beta subunit (non-catalytic)
Synonyms

B230339M05Rik, mKIAA1219

Feature Type

protein coding gene
IDs

MGI:2444531
NCBI Gene: 228850
Alliance

genome feature page
Transcription Start Sites

10 TSS

Sequence Map

Chr2:158251768-158341173 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 78.72 cM
Mapping Data

2 experiments

SNPs within 2kb

1749 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2444531	protein coding gene	Chr2:158251722-158341173 (+)
129S1/SvImJ	ENSMUSG00200015321	protein coding gene	Chr2:155119200-155197626 (+)
A/J	ENSMUSG00195021512	protein coding gene	Chr2:155487725-155565266 (+)
AKR/J	ENSMUSG00220011862	protein coding gene	Chr2:154816952-154894492 (+)
BALB/cJ	ENSMUSG00180042235	protein coding gene	Chr2:154941173-155018713 (+)
C3H/HeJ	ENSMUSG00175050222	protein coding gene	Chr2:155691304-155768842 (+)
C57BL/6NJ	ENSMUSG00215034643	protein coding gene	Chr2:155112374-155190814 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0024588	protein coding gene	Chr2:150366028-150455055 (+)
CAST/EiJ	ENSTCUG00005045859	protein coding gene	Chr2:154092236-154169798 (+)
CBA/J	ENSMUSG00210015373	protein coding gene	Chr2:155622423-155699959 (+)
DBA/2J	ENSMUSG00185046927	protein coding gene	Chr2:155341544-155419162 (+)
FVB/NJ	ENSMUSG00205035817	protein coding gene	Chr2:154373532-154451071 (+)
JF1/MsJ	ENSUMUG00000012198	protein coding gene	Chr2:154997404-155075037 (+)
LP/J	ENSMUSG00230042884	protein coding gene	Chr2:156916717-156995141 (+)
NOD/ShiLtJ	ENSMUSG00190039398	protein coding gene	Chr2:155016423-155093959 (+)
NZO/HlLtJ	ENSMUSG00225049133	protein coding gene	Chr2:164931952-165009478 (+)
PWK/PhJ	ENSLUMG00010047084	protein coding gene	Chr2:154935943-155013758 (+)
SPRET/EiJ	ENSMSPG00010031889	protein coding gene	Chr2:157686260-157777059 (+)
WSB/EiJ	ENSIUOG00005045046	protein coding gene	Chr2:154717250-154794863 (+)

Human Ortholog

RALGAPB, Ral GTPase activating protein non-catalytic subunit beta

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

RALGAPB, Ral GTPase activating protein non-catalytic subunit beta
Synonyms

KIAA1219, RalGAPbeta
Links

HGNC:29221

NCBI Gene ID: 57148

UniProt: Q86X10
Chr Location

20q11.23; chr20:38472816-38578859 (+) GRCh38

MGI Vertebrate Homology

Ralgapb stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: RALGAPB
Gene Tree

Ralgapb

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Phenotype Summary

2 phenotypes from 1 allele in 1 genetic background
12 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

15
Endonuclease-mediated

1
Gene trapped

12
Targeted

2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

72 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

18
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

642
Tissues

31
cDNA Data

14
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase ralgapb

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All Sequences

90
RefSeq

29
UniProt

7
CCDS

CCDS50786.1, CCDS71178.1, CCDS71179.1

Ensembl

ENSMUSG00000027652 (Evidence)
NCBI Gene

228850

			Length	Strain/Species	Flank
genomic	ENSMUSG00000027652	Ensembl Gene Model \| MGI Sequence Detail	89406	C57BL/6J	± kb
transcript	ENSMUST00000109485	Ensembl \| MGI Sequence Detail	6709	Not Applicable
polypeptide	ENSMUSP00000105111	Ensembl \| MGI Sequence Detail	1507	Not Applicable

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UniProt

7 Sequences
Protein Ontology

PR:000031298 Ral GTPase-activating protein subunit beta

(term hierarchy)
InterPro Domains

IPR046859 Ral GTPase-activating protein subunit alpha/beta, N-terminal domain

IPR039930 Ral GTPase-activating protein subunit beta

IPR000331 Rap/Ran-GAP domain

IPR035974 Rap/Ran-GAP superfamily
GlyGen

Q8BQZ4 3 sites, 1 O-linked glycan (1 site)

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All nucleic 14

cDNA 14

Microarray probesets 3

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MGI:2138996

Summaries

All 43

Developmental Gene Expression 2

Gene Ontology 7

Phenotypes 12
Earliest

J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
Latest

J:367792 Apken LH, et al., RalGAP complexes control secretion and primary cilia in pancreatic disease. Life Sci Alliance. 2025 Aug;8(8)

TSS for Ralgapb:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr21339	Chr2:158251711-158251720 (+)	-52 bp
Tssr21340	Chr2:158251762-158251782 (+)	4 bp
Tssr21341	Chr2:158251787-158251826 (+)	39 bp
Tssr21342	Chr2:158251827-158251838 (+)	65 bp
Tssr21343	Chr2:158251840-158251855 (+)	80 bp
Tssr21344	Chr2:158252087-158252091 (+)	321 bp
Tssr21345	Chr2:158258632-158258641 (+)	6,869 bp
Tssr21346	Chr2:158278916-158278936 (+)	27,158 bp
Tssr21347	Chr2:158278944-158278961 (+)	27,185 bp
Tssr21348	Chr2:158281757-158281761 (+)	29,991 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/01/2026 MGI 6.24