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Marf1 Gene Detail
Summary
  • Symbol
    Marf1
  • Name
    meiosis regulator and mRNA stability 1
  • Synonyms
    4921513D23Rik, MGC:36956
  • Feature Type
    protein coding gene
  • IDs
    MGI:2444505
    NCBI Gene: 223989
  • Gene Overview
    MyGene.info: MARF1
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr16:14109166-14159274 bp, - strand
  • From NCBI annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      50109 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 16, 9.69 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    MARF1, meiosis regulator and mRNA stability factor 1
  • Vertebrate Orthologs
    8
  • Human Ortholog
    MARF1, meiosis regulator and mRNA stability factor 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    KIAA0430, LKAP, LMKB, PPP1R34
  • Links
    NCBI Gene ID: 9665
    neXtProt AC: NX_Q9Y4F3
    UniProt: Q9Y4F3

  • Chr Location
    16p13.11; chr16:15594369-15643166 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotypes from 2 alleles in 3 genetic backgrounds
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for an ENU-induced mutation exhibit female infertility with abnormalities in oogenic processes including meiotic progression, genomic integrity and acquisition of developmental competence.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 223989 NCBI Gene Model | MGI Sequence Detail 50109 C57BL/6J ±  kb
    transcript NM_001081154 RefSeq | MGI Sequence Detail 7765 C57BL/6  
    polypeptide Q8BJ34 UniProt | EBI | MGI Sequence Detail 1730 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      156 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 13
      cDNA 11
      Primer pair 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2146729, MGI:2387606
    References
    more
    • Summaries
      All 29
      Developmental Gene Expression 3
      Gene Ontology 5
      Phenotypes 6
    • Earliest
      J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
    • Latest
      J:191238 Su YQ, et al., Meiosis arrest female 1 (MARF1) has nuage-like function in mammalian oocytes. Proc Natl Acad Sci U S A. 2012 Nov 13;109(46):18653-60

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
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    last database update
    05/15/2018
    MGI 6.12
    The Jackson Laboratory