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Casc1 Gene Detail
Summary
  • Symbol
    Casc1
  • Name
    cancer susceptibility candidate 1
  • Synonyms
    A230084G12Rik, Las1
  • Feature Type
    protein coding gene
  • IDs
    MGI:2444480
    NCBI Gene: 320662
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:145120560-145156731 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 77.37 cM
  • Mapping Data
    8 experiments
Strain
Comparison
more
  • SNPs within 2kb
    418 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2444480
protein coding gene Chr6:145120556-145156866 (-)
129S1/SvImJ MGP_129S1SvImJ_G0031477
protein coding gene Chr6:150157947-150195112 (-)
A/J MGP_AJ_G0031452
protein coding gene Chr6:144213266-144249840 (-)
AKR/J MGP_AKRJ_G0031380
protein coding gene Chr6:148510575-148546633 (-)
BALB/cJ MGP_BALBcJ_G0031459
protein coding gene Chr6:143970031-144006109 (-)
C3H/HeJ MGP_C3HHeJ_G0031181
protein coding gene Chr6:148543795-148580279 (-)
C57BL/6NJ MGP_C57BL6NJ_G0031921
protein coding gene Chr6:154208603-154246619 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029045
protein coding gene Chr6:142963515-143002087 (-)
CAST/EiJ MGP_CASTEiJ_G0030549
protein coding gene Chr6:148166553-148202935 (-)
CBA/J MGP_CBAJ_G0031141
protein coding gene Chr6:160067661-160105426 (-)
DBA/2J MGP_DBA2J_G0031298
protein coding gene Chr6:143018217-143054228 (-)
FVB/NJ MGP_FVBNJ_G0031249
protein coding gene Chr6:141748680-141784923 (-)
LP/J MGP_LPJ_G0031382
protein coding gene Chr6:150256203-150297026 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0031289
protein coding gene Chr6:163857457-163894275 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0031953
protein coding gene Chr6:148343134-148379751 (-)
PWK/PhJ MGP_PWKPhJ_G0030276
protein coding gene Chr6:141520189-141558244 (-)
SPRET/EiJ MGP_SPRETEiJ_G0030100
protein coding gene Chr6:146499937-146536022 (-)
WSB/EiJ MGP_WSBEiJ_G0030642
protein coding gene Chr6:148939364-148977727 (-)



Homology
more
  • Human Ortholog
    DNAI7, dynein axonemal intermediate chain 7
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DNAI7, dynein axonemal intermediate chain 7
  • Synonyms
    CASC1, CFAP94, LAS1, PPP1R54
  • Links
    NCBI Gene ID: 55259
    neXtProt AC: NX_Q6TDU7
    UniProt: Q6TDU7

  • Chr Location
    12p12.1; chr12:25107057-25195177 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice with disruptions of this gene display a higher incidence of lung tumors.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • cDNA Data
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000043541 Ensembl Gene Model | MGI Sequence Detail 36172 C57BL/6J ±  kb
    transcript ENSMUST00000060797 Ensembl | MGI Sequence Detail 2572 Not Applicable  
    polypeptide ENSMUSP00000062279 Ensembl | MGI Sequence Detail 730 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 14
      cDNA 14

      Microarray probesets 1
    References
    more
    • Summaries
      All 29
      Gene Ontology 6
      Phenotypes 6
    • Earliest
      J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
    • Latest
      J:289069 Zhang Y, et al., Vertebrate Dynein-f depends on Wdr78 for axonemal localization and is essential for ciliary beat. J Mol Cell Biol. 2019 May 1;11(5):383-394

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    last database update
    11/22/2022
    MGI 6.22
    The Jackson Laboratory