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Casc1 Gene Detail
Summary
  • Symbol
    Casc1
  • Name
    cancer susceptibility candidate 1
  • Synonyms
    A230084G12Rik, Las1
  • Feature Type
    protein coding gene
  • IDs
    MGI:2444480
    NCBI Gene: 320662
Location & Maps
more
  • Sequence Map
    Chr6:145174834-145211005 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      36172 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 77.37 cM
  • Mapping Data
    8 experiments
Homology
more
  • Human Ortholog
    CASC1, cancer susceptibility candidate 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    CASC1, cancer susceptibility candidate 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    LAS1, PPP1R54
  • Links
    NCBI Gene ID: 55259
    neXtProt AC: NX_Q6TDU7

  • Chr Location
    12p12.1; chr12:25107057-25195162 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    5 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice with disruptions of this gene display a higher incidence of lung tumors.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000023460 VEGA Gene Model | MGI Sequence Detail 36172 C57BL/6J ±  kb
transcript OTTMUST00000057040 VEGA | MGI Sequence Detail 2572 Not Applicable  
polypeptide OTTMUSP00000027475 VEGA | MGI Sequence Detail 730 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    418 from dbSNP Build 142
Protein
Information
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  • UniProt
    5 Sequences
  • InterPro Domains
    IPR031826 Cancer susceptibility candidate 1, N-terminal
    IPR023247 Cancer susceptibility candidate protein 1
Molecular
Reagents
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  • All nucleic 13
    cDNA 13

    Microarray probesets 1
References
more
  • Summaries
    All 24
    Gene Ontology 2
    Phenotypes 5
  • Earliest
    J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
  • Latest
    J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory