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Fbxl18 Gene Detail
Summary
  • Symbol
    Fbxl18
  • Name
    F-box and leucine-rich repeat protein 18
  • Synonyms
    B130019G13Rik, C330021B20Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2444450
    NCBI Gene: 231863
  • Alliance
    genome feature page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:142852701-142881176 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 81.79 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    958 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2444450
 protein coding gene Chr5:142852701-142882696 (-)
129S1/SvImJ ENSMUSG00200039097
 protein coding gene Chr5:136723658-136751983 (-)
A/J ENSMUSG00195039616
 protein coding gene Chr5:136365050-136393531 (-)
AKR/J ENSMUSG00220022399
 protein coding gene Chr5:135601028-135629353 (-)
BALB/cJ ENSMUSG00180028347
 protein coding gene Chr5:136467111-136495594 (-)
C3H/HeJ ENSMUSG00175033933
 protein coding gene Chr5:138392674-138421157 (-)
C57BL/6NJ ENSMUSG00215040515
 protein coding gene Chr5:136301272-136329748 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027967
 protein coding gene Chr5:135602445-135630989 (-)
CAST/EiJ ENSTCUG00005028061
 protein coding gene Chr5:135746848-135774852 (-)
CBA/J ENSMUSG00210023164
 protein coding gene Chr5:137194361-137222853 (-)
DBA/2J ENSMUSG00185051981
 protein coding gene Chr5:140200414-140228734 (-)
FVB/NJ ENSMUSG00205038634
 protein coding gene Chr5:136023442-136051925 (-)
JF1/MsJ ENSUMUG00000023153
 protein coding gene Chr5:143072616-143100523 (-)
LP/J ENSMUSG00230028827
 protein coding gene Chr5:144327422-144355742 (-)
NOD/ShiLtJ ENSMUSG00190030555
 protein coding gene Chr5:136162427-136190902 (-)
NZO/HlLtJ ENSMUSG00225022851
 protein coding gene Chr5:151796693-151825169 (-)
PWK/PhJ ENSLUMG00010020163
 protein coding gene Chr5:134786503-134814535 (-)
SPRET/EiJ ENSMSPG00010025050
 protein coding gene Chr5:138404753-138428122 (-)
WSB/EiJ ENSIUOG00005036819
 protein coding gene Chr5:138686290-138714829 (-)



Homology
more
  • Human Ortholog
    FBXL18, F-box and leucine rich repeat protein 18
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FBXL18, F-box and leucine rich repeat protein 18
  • Synonyms
    Fbl18
  • Links
    NCBI Gene ID: 80028
    UniProt: Q96ME1

  • Chr Location
    7p22.1; chr7:5431335-5513809 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    2
  • GO References
    2
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    597
  • cDNA Data
    11
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000066640 Ensembl Gene Model | MGI Sequence Detail 28476 C57BL/6J ±  kb
    transcript ENSMUST00000110766 Ensembl | MGI Sequence Detail 7857 Not Applicable  
    polypeptide ENSMUSP00000106394 Ensembl | MGI Sequence Detail 771 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      5 Sequences
    • InterPro Domains
      IPR001810 F-box domain
      IPR036047 F-box-like domain superfamily
      IPR047948 F-box/LRR-repeat protein 18, F-box domain
      IPR045627 F-box/LRR-repeat protein 18, LRR domain
      IPR032675 Leucine-rich repeat domain superfamily
    • GlyGen
      F8VQK6 1 site, 1 N-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 11
      cDNA 11

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2140868
    References
    more
    • Summaries
      All 32
      Gene Ontology 2
      Phenotypes 10
    • Earliest
      J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory