Rab11fip3 MGI Mouse Gene Detail - MGI:2444431 - RAB11 family interacting protein 3 (class II)

Symbol

Rab11fip3
Name

RAB11 family interacting protein 3 (class II)
Synonyms

D030060O14Rik, mKIAA0665, Rab11-FIP3

Feature Type

protein coding gene
IDs

MGI:2444431
NCBI Gene: 215445
Alliance

genome feature page
Transcription Start Sites

17 TSS

Sequence Map

Chr17:26208010-26288529 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 17, 13.05 cM
Mapping Data

2 experiments

SNPs within 2kb

2346 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2444431	protein coding gene	Chr17:26208010-26289010 (-)
129S1/SvImJ	ENSMUSG00200047442	protein coding gene	Chr17:21653055-21733957 (-)
A/J	ENSMUSG00195054255	protein coding gene	Chr17:22670222-22750830 (-)
AKR/J	ENSMUSG00220052309	protein coding gene	Chr17:21717019-21797923 (-)
BALB/cJ	ENSMUSG00180049748	protein coding gene	Chr17:21951084-22031988 (-)
C3H/HeJ	ENSMUSG00175053584	protein coding gene	Chr17:21709250-21790191 (-)
C57BL/6NJ	ENSMUSG00215053239	protein coding gene	Chr17:21717619-21798141 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0021269	protein coding gene	Chr17:21826551-21906178 (-)
CAST/EiJ	ENSTCUG00005047991	protein coding gene	Chr17:22298947-22378624 (-)
CBA/J	ENSMUSG00210049465	protein coding gene	Chr17:21548088-21629025 (-)
DBA/2J	ENSMUSG00185052626	protein coding gene	Chr17:23758465-23839077 (-)
FVB/NJ	ENSMUSG00205026174	protein coding gene	Chr17:22014181-22094792 (-)
JF1/MsJ	ENSUMUG00000054851	protein coding gene	Chr17:23213648-23294610 (-)
LP/J	ENSMUSG00230054616	protein coding gene	Chr17:25157586-25238480 (-)
NOD/ShiLtJ	ENSMUSG00190041841	protein coding gene	Chr17:21647186-21727789 (-)
NZO/HlLtJ	ENSMUSG00225054049	protein coding gene	Chr17:27077533-27158140 (-)
PWK/PhJ	ENSLUMG00010045881	protein coding gene	Chr17:21132709-21208361 (-)
SPRET/EiJ	ENSMSPG00010047874	protein coding gene	Chr17:22452626-22530866 (-)
WSB/EiJ	ENSIUOG00005050878	protein coding gene	Chr17:22390893-22470390 (-)

Human Ortholog

RAB11FIP3, RAB11 family interacting protein 3

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

RAB11FIP3, RAB11 family interacting protein 3
Synonyms

CART1, FIP3, FIP3-Rab11, Rab11-FIP3
Links

HGNC:17224

NCBI Gene ID: 9727

UniProt: O75154
Chr Location

16p13.3; chr16:425593-523012 (+) GRCh38

MGI Vertebrate Homology

Rab11fip3 stringent orthology
1 human;1 mouse;1 zebrafish
HCOP

vertebrate homology predictions: RAB11FIP3
Gene Tree

Rab11fip3

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Phenotype Summary

7 phenotypes from 1 allele in 1 genetic background
13 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

14
Endonuclease-mediated

4
Gene trapped

6
Radiation induced

2
Targeted

2
Genomic Mutations

2 involving Rab11fip3
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

49 strains or lines available

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All GO Annotations

104
GO References

10

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

642
Tissues

36
cDNA Data

89
Literature Summary

3

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase rab11fip3

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All Sequences

63
RefSeq

15
UniProt

1
CCDS

CCDS50039.1, CCDS50040.1, CCDS50041.1

Ensembl

ENSMUSG00000037098 (Evidence)
NCBI Gene

215445

			Length	Strain/Species	Flank
genomic	ENSMUSG00000037098	Ensembl Gene Model \| MGI Sequence Detail	80520	C57BL/6J	± kb
transcript	ENSMUST00000122103	Ensembl \| MGI Sequence Detail	5383	Not Applicable
polypeptide	ENSMUSP00000113521	Ensembl \| MGI Sequence Detail	1092	Not Applicable

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UniProt

1 Sequence
InterPro Domains

IPR002048 EF-hand domain

IPR011992 EF-hand domain pair

IPR037245 FIP-RBD, C-terminal domain superfamily

IPR051977 Rab11 family-interacting protein 3/4

IPR057316 Rab11-FIP3/4 domain

IPR019018 Rab-binding domain FIP-RBD

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All nucleic 92

cDNA 90

Primer pair 2

Microarray probesets 2

Summaries

All 44

Developmental Gene Expression 3

Gene Ontology 10

Phenotypes 13
Earliest

J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Rab11fip3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr146905	Chr17:26288449-26288524 (-)	42 bp
Tssr146904	Chr17:26277653-26277655 (-)	10,875 bp
Tssr146903	Chr17:26240915-26240933 (-)	47,605 bp
Tssr146902	Chr17:26240890-26240909 (-)	47,629 bp
Tssr146901	Chr17:26240827-26240840 (-)	47,695 bp
Tssr146900	Chr17:26240810-26240819 (-)	47,714 bp
Tssr146899	Chr17:26240788-26240795 (-)	47,737 bp
Tssr146898	Chr17:26240769-26240781 (-)	47,754 bp
Tssr146897	Chr17:26240716-26240731 (-)	47,805 bp
Tssr146896	Chr17:26240710-26240715 (-)	47,816 bp
Tssr146895	Chr17:26238706-26238721 (-)	49,815 bp
Tssr146894	Chr17:26227852-26227896 (-)	60,655 bp
Tssr146893	Chr17:26223864-26223879 (-)	64,657 bp
Tssr146892	Chr17:26223828-26223847 (-)	64,691 bp
Tssr146891	Chr17:26223807-26223818 (-)	64,716 bp
Tssr146890	Chr17:26223777-26223794 (-)	64,743 bp
Tssr146889	Chr17:26223687-26223726 (-)	64,822 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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