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Cyb5r2 Gene Detail
Summary
  • Symbol
    Cyb5r2
  • Name
    cytochrome b5 reductase 2
  • Synonyms
    D630003K02Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2444415
    NCBI Gene: 320635
  • Gene Overview
    MyGene.info: CYB5R2
Location & Maps
more
  • Sequence Map
    Chr7:107748455-107758032 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      9578 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 57.21 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    CYB5R2, cytochrome b5 reductase 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    CYB5R2, cytochrome b5 reductase 2
    Orthology source: HGNC, HomoloGene
  • Synonyms
    B5R.2
  • Links
    NCBI Gene ID: 51700
    neXtProt AC: NX_Q6BCY4

  • Chr Location
    11p15.4; chr11:7665095-7674341 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    13 phenotype references
  • All Mutations and Alleles
    4
  • Chemically induced (other)
    1
  • Radiation induced
    1
  • Targeted
    2
  • Genomic Mutations
    2 involving Cyb5r2
  • Incidental Mutations
Mice homozygous for a targeted allele exhibit normal cATR-induced effects on mitochondria membrane potential during respiratory arrest by rotenone or anoxia.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000059945 VEGA Gene Model | MGI Sequence Detail 9578 C57BL/6J ±  kb
transcript OTTMUST00000146849 VEGA | MGI Sequence Detail 2772 Not Applicable  
polypeptide OTTMUSP00000076390 VEGA | MGI Sequence Detail 292 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    186 from dbSNP Build 142
Protein
Information
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  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000006081 NADH-cytochrome b5 reductase 2
  • EC
  • InterPro Domains
    IPR017927 Ferredoxin reductase-type FAD-binding domain
    IPR001709 Flavoprotein pyridine nucleotide cytochrome reductase
    IPR001834 NADH:cytochrome b5 reductase (CBR)
    IPR008333 Oxidoreductase, FAD-binding domain
    IPR001433 Oxidoreductase FAD/NAD(P)-binding
    IPR017938 Riboflavin synthase-like beta-barrel
Molecular
Reagents
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  • All nucleic 7
    cDNA 7

    Microarray probesets 2
References
more
  • Summaries
    All 25
    Gene Ontology 5
    Phenotypes 13
  • Earliest
    J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
  • Latest
    J:211614 Kiss G, et al., Mitochondrial diaphorases as NAD(+) donors to segments of the citric acid cycle that support substrate-level phosphorylation yielding ATP during respiratory inhibition. FASEB J. 2014 Apr;28(4):1682-97

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory