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Cyb5r2 Gene Detail
Summary
  • Symbol
    Cyb5r2
  • Name
    cytochrome b5 reductase 2
  • Synonyms
    D630003K02Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2444415
    NCBI Gene: 320635
  • Gene Overview
    MyGene.info: CYB5R2
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:107748455-107758032 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 57.21 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    186 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2444415
protein coding gene Chr7:107748446-107758199 (-)
129S1/SvImJ MGP_129S1SvImJ_G0032799
protein coding gene Chr7:111089884-111099461 (-)
A/J MGP_AJ_G0032780
protein coding gene Chr7:108334437-108344014 (-)
AKR/J MGP_AKRJ_G0032712
protein coding gene Chr7:111056333-111065910 (-)
BALB/cJ MGP_BALBcJ_G0032786
protein coding gene Chr7:108032221-108041798 (-)
C3H/HeJ MGP_C3HHeJ_G0032495
protein coding gene Chr7:111076322-111085899 (-)
C57BL/6NJ MGP_C57BL6NJ_G0033291
protein coding gene Chr7:115674936-115684513 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0030269
protein coding gene Chr7:109982752-109992673 (-)
CAST/EiJ MGP_CASTEiJ_G0031826
protein coding gene Chr7:102682760-102692436 (-)
CBA/J MGP_CBAJ_G0032470
protein coding gene Chr7:119484552-119494129 (-)
DBA/2J MGP_DBA2J_G0032621
protein coding gene Chr7:106465242-106474819 (-)
FVB/NJ MGP_FVBNJ_G0032573
protein coding gene Chr7:106317998-106327575 (-)
LP/J MGP_LPJ_G0032713
protein coding gene Chr7:112687138-112696715 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0032607
protein coding gene Chr7:121092797-121102487 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0033310
protein coding gene Chr7:110118025-110128839 (-)
PWK/PhJ MGP_PWKPhJ_G0031532
protein coding gene Chr7:99337954-99347527 (-)
SPRET/EiJ MGP_SPRETEiJ_G0031382
protein coding gene Chr7:96706734-96716464 (-)
WSB/EiJ MGP_WSBEiJ_G0031941
protein coding gene Chr7:110869333-110879073 (-)



Homology
more
  • Human Ortholog
    CYB5R2, cytochrome b5 reductase 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    CYB5R2, cytochrome b5 reductase 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    B5R.2
  • Links
    NCBI Gene ID: 51700
    neXtProt AC: NX_Q6BCY4
    UniProt: Q6BCY4

  • Chr Location
    11p15.4; chr11:7665095-7678568 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    15 phenotype references
Mice homozygous for a targeted allele exhibit normal cATR-induced effects on mitochondria membrane potential during respiratory arrest by rotenone or anoxia.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000048065 Ensembl Gene Model | MGI Sequence Detail 9578 C57BL/6J ±  kb
transcript ENSMUST00000052438 Ensembl | MGI Sequence Detail 2772 Not Applicable  
polypeptide ENSMUSP00000050061 Ensembl | MGI Sequence Detail 292 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000006081 NADH-cytochrome b5 reductase 2
  • EC
  • InterPro Domains
    IPR017927 FAD-binding domain, ferredoxin reductase-type
    IPR039261 Ferredoxin-NADP reductase (FNR), nucleotide-binding domain
    IPR001709 Flavoprotein pyridine nucleotide cytochrome reductase
    IPR008333 Flavoprotein pyridine nucleotide cytochrome reductase-like, FAD-binding domain
    IPR001834 NADH:cytochrome b5 reductase (CBR)
    IPR001433 Oxidoreductase FAD/NAD(P)-binding
    IPR017938 Riboflavin synthase-like beta-barrel
Molecular
Reagents
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  • All nucleic 8
    cDNA 8

    Microarray probesets 2
References
more
  • Summaries
    All 37
    Gene Ontology 6
    Phenotypes 15
  • Earliest
    J:88307 Giometti CS, et al., The analysis of recessive lethal mutations in mice by using two-dimensional gel electrophoresis of liver proteins. Mutat Res. 1990 Sep;242(1):47-55
  • Latest
    J:236599 Dickinson ME, et al., High-throughput discovery of novel developmental phenotypes. Nature. 2016 Sep 14;537(7621):508-514

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory