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Rapgef5 Gene Detail
Summary
  • Symbol
    Rapgef5
  • Name
    Rap guanine nucleotide exchange factor (GEF) 5
  • Synonyms
    D030051B22Rik, mKIAA0277, mr-gef
  • Feature Type
    protein coding gene
  • IDs
    MGI:2444365
    NCBI Gene: 217944
  • Gene Overview
    MyGene.info: RAPGEF5
  • Alliance
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:117516479-117759737 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 12, 63.06 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    1977 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2444365
protein coding gene Chr12:117516479-117759737 (.)
129S1/SvImJ MGP_129S1SvImJ_G0020184
protein coding gene Chr12:120433029-120693660 (+)
A/J MGP_AJ_G0020140
protein coding gene Chr12:116000554-116249195 (+)
AKR/J MGP_AKRJ_G0020115
protein coding gene Chr12:119517490-119762990 (+)
BALB/cJ MGP_BALBcJ_G0020123
protein coding gene Chr12:116424168-116670170 (+)
C3H/HeJ MGP_C3HHeJ_G0019927
protein coding gene Chr12:119805919-120058213 (+)
C57BL/6NJ MGP_C57BL6NJ_G0020570
protein coding gene Chr12:124212643-124468400 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0018182
protein coding gene Chr12:112391172-112637081 (+)
CAST/EiJ MGP_CASTEiJ_G0019467
protein coding gene Chr12:113651912-113909316 (+)
CBA/J MGP_CBAJ_G0019894
protein coding gene Chr12:129115061-129377417 (+)
DBA/2J MGP_DBA2J_G0020011
protein coding gene Chr12:115392967-115641526 (+)
FVB/NJ MGP_FVBNJ_G0019996
protein coding gene Chr12:114071331-114317852 (+)
LP/J MGP_LPJ_G0020085
protein coding gene Chr12:120472211-120728838 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0020032
protein coding gene Chr12:132381771-132636305 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0020599
protein coding gene Chr12:118689945-118937297 (+)
PWK/PhJ MGP_PWKPhJ_G0019229
protein coding gene Chr12:110144725-110394397 (+)
SPRET/EiJ MGP_SPRETEiJ_G0019034
protein coding gene Chr12:111644233-111898677 (+)
WSB/EiJ MGP_WSBEiJ_G0019525
protein coding gene Chr12:119663030-119917285 (+)



Homology
more
  • Human Ortholog
    RAPGEF5, Rap guanine nucleotide exchange factor 5
  • Vertebrate Orthologs
    9
  • Human Ortholog
    RAPGEF5, Rap guanine nucleotide exchange factor 5
    Orthology source: HomoloGene, HGNC
  • Synonyms
    GFR, MR-GEF, REPAC
  • Links
    NCBI Gene ID: 9771
    neXtProt AC: NX_Q92565
    UniProt: Q92565

  • Chr Location
    7p15.3; chr7:22118290-22357133 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 217944 NCBI Gene Model | MGI Sequence Detail 243259 C57BL/6J ±  kb
transcript NM_175930 RefSeq | MGI Sequence Detail 3987 C57BL/6  
polypeptide Q8C0Q9 UniProt | EBI | MGI Sequence Detail 814 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000013730 rap guanine nucleotide exchange factor 5
  • InterPro Domains
    IPR000591 DEP domain
    IPR036964 Ras guanine-nucleotide exchange factor catalytic domain superfamily
    IPR019804 Ras guanine-nucleotide exchange factor, conserved site
    IPR023578 Ras guanine nucleotide exchange factor domain superfamily
    IPR001895 Ras guanine-nucleotide exchange factors catalytic domain
    IPR000651 Ras-like guanine nucleotide exchange factor, N-terminal
    IPR029071 Ubiquitin-like domain superfamily
    IPR036390 Winged helix DNA-binding domain superfamily
    IPR036388 Winged helix-like DNA-binding domain superfamily
Molecular
Reagents
less
  • All nucleic 97
    cDNA 95
    Primer pair 1
    Other 1

    Microarray probesets 6
Other
Accession IDs
less
MGI:2141775
References
more
  • Summaries
    All 34
    Developmental Gene Expression 6
    Gene Ontology 3
    Phenotypes 5
  • Earliest
    J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
  • Latest
    J:241394 Mattiske T, et al., Embryonic forebrain transcriptome of mice with polyalanine expansion mutations in the ARX homeobox gene. Hum Mol Genet. 2016 Dec 15;25(24):5433-5443

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory