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Arid4a
Gene Detail
Symbol

Name
ID
Arid4a
AT rich interactive domain 4A (RBP1-like)
MGI:2444354
Synonyms
A630067N03Rik, Rbbp1
Feature Type
protein coding gene
Genetic Map
Chromosome 12
29.39 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr12:71015990-71098592 bp, + strand
From VEGA annotation of GRCm38

  82603 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:11303  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

Gene Tree: Arid4a

Human
homologs
Human Homolog ARID4A, AT rich interactive domain 4A (RBP1-like)
NCBI Gene ID 5926
neXtProt AC  NX_P29374
Human Synonyms  RBBP1, RBBP-1, RBP1, RBP-1
Human Chr (Location)  14q23.1; chr14:58298385-58373995 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(29) : Gene trapped(26) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit altered DNA methylation patterns, disrupted hematopoiesis and a portion develop acute myeloid leukemia.
 
Human Diseases Modeled Using Mouse Arid4a (1)    Alleles Annotated to Human Diseases(1)   
Interactions
Arid4a interacts with 336 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (2 records)
Data Summary: Results (94)    Tissues (94)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 94
cDNA source data(14)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(15) cDNA(14) Other(1)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000017260 (Evidence)
Ensembl Gene ModelENSMUSG00000048118 (Evidence)
Entrez Gene238247 (Evidence)
DFCITC1623606, TC1638855, TC1694919, TC1583085
DoTSDT.101366605, DT.101154032, DT.91368089, DT.97386971, DT.91325958, DT.94198121
NIA Mouse Gene IndexU014048
Consensus CDS ProjectCCDS36471.1
International Mouse Knockout Project StatusArid4a
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000017260 VEGA Gene Model | MGI Sequence Detail 82603 C57BL/6J ±  kb
transcript OTTMUST00000041768 VEGA | MGI Sequence Detail 4998 Not Applicable 
polypeptide OTTMUSP00000018775 VEGA | MGI Sequence Detail 1261 Not Applicable 

For the selected sequences
All sequences(74) RefSeq(8) UniProt(20)
Polymorphisms
SNPs within 2kb(536 from dbSNP Build 137)    SNPs within 2kb including multiple locations(540)
Protein-related
information
ResourceIDDescription
InterPro IPR001606 ARID/BRIGHT DNA-binding domain
InterPro IPR016197 Chromo domain-like
InterPro IPR000953 Chromo domain/shadow
InterPro IPR012603 RBB1NT
InterPro IPR025995 RNA binding activity-knot of a chromodomain
InterPro IPR002999 Tudor domain
Protein Ontology PR:000004267 AT-rich interactive domain-containing protein 4A
References
(Earliest) J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
(Latest) J:214809 Moniot B, et al., Prostaglandin D2 acts through the Dp2 receptor to influence male germ cell differentiation in the foetal mouse testis. Development. 2014 Sep;141(18):3561-71
All references(40)
Disease annotation references (1)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/16/2014
MGI 5.20
The Jackson Laboratory