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Vps13a
Gene Detail
Symbol

Name
ID
Vps13a
vacuolar protein sorting 13A (yeast)
MGI:2444304
Synonyms
4930516E05Rik, 4930543C13Rik, D330038K10Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 19
11.71 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr19:16616763-16780822 bp, - strand
From Ensembl annotation of GRCm38

  164060 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:22068  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: VPS13A
Gene Tree: Vps13a

Human
homologs
VPS13A, vacuolar protein sorting 13 homolog A (S. cerevisiae)
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 23230
neXtProt AC: NX_Q96RL7

Human Synonyms: CHAC, CHOREIN

Human Chr (Location): 9q21; chr9:77177353-77417483 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human VPS13A

Mutations,
alleles, and
phenotypes
All mutations/alleles(9) : Gene trapped(5) Targeted(4)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Aging mice homozygous for a knock-out allele display motor dysfunction and abnormal social interaction, hematologic anomalies including acanthocytosis, selective atrophy of the striatum with significant apoptosis and gliosis, and reduced homovanillic acid levels in midbrain.
 
Human Diseases Modeled in Mice Using Vps13a (1)    Mutations Annotated to Human Diseases (1)   
Interactions
Vps13a interacts with 190 markers (Mir1a-1, Mir1a-2, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (12 annotations)
Process locomotory behavior, nervous system development, ...
Component cell, dense core granule, ...
Function molecular_function
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (47)    Tissues (29)    Images (18)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 47
cDNA source data(73)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: Xenbase vps13a ; ZFIN vps13a    NEW 
Molecular
reagents
All nucleic(75) cDNA(75)
Microarray probesets(8)
Other database
links
Ensembl Gene Model ENSMUSG00000046230 (Evidence)
Entrez Gene 271564 (Evidence)
UniGene 211963
DFCI TC1606130, TC1580817, TC1662241, TC1603652, TC1675599, TC1673813, TC1716205, TC1624604, TC1611244
DoTS DT.101702852, DT.101712061, DT.101715726, DT.40145133, DT.101358001, DT.110861144, DT.40151365, DT.101320825, DT.55232405, DT.94129921, DT.524294
NIA Mouse Gene Index U038891
Consensus CDS Project CCDS37929.1
International Mouse Phenotyping Consortium Status Vps13a
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000046230 Ensembl Gene Model | MGI Sequence Detail 164060 C57BL/6J ±  kb
transcript ENSMUST00000068156 Ensembl | MGI Sequence Detail 9656 Not Applicable 
polypeptide ENSMUSP00000068716 Ensembl | MGI Sequence Detail 3166 Not Applicable 

For the selected sequences
All sequences(82) RefSeq(8) UniProt(10)
Polymorphisms
SNPs within 2kb(1280 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR015412 Autophagy-related, C-terminal
InterPro IPR026847 Vacuolar protein sorting-associated protein 13
InterPro IPR026854 Vacuolar protein sorting-associated protein 13A N-terminal domain
InterPro IPR009543 Vacuolar protein sorting-associated protein 13 domain
Protein Ontology PR:000017319 vacuolar protein sorting-associated protein 13A
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:182594 Hayashi T, et al., Subcellular localization and putative role of VPS13A/chorein in dopaminergic neuronal cells. Biochem Biophys Res Commun. 2012 Mar 16;419(3):511-6
All references(35)
Disease annotation references (1)
Other
accession IDs
MGI:1922380, MGI:1926182

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory