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Vps13a
Gene Detail
 Symbol
Name
ID
Vps13a
vacuolar protein sorting 13A (yeast)
MGI:2444304
Synonyms 4930516E05Rik, 4930543C13Rik, D330038K10Rik
Feature Type protein coding gene
Genetic Map
Chromosome 19
11.71 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr19:16616763-16780822 bp, - strand
From Ensembl annotation of GRCm38

  164060 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:22068  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 zebrafish

Gene Tree: Vps13a

Human
homologs
Human Homolog VPS13A, vacuolar protein sorting 13 homolog A (S. cerevisiae)
NCBI Gene ID 23230
neXtProt AC  NX_Q96RL7
Human Synonyms  CHAC, CHOREIN
Human Chr (Location)  9q21; chr9:77177353-77417483 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human VPS13A
Alleles
and
phenotypes
All alleles(8) : Targeted(3) Gene trapped(5)
 
Aging mice homozygous for a knock-out allele display motor dysfunction and abnormal social interaction, hematologic anomalies including acanthocytosis, selective atrophy of the striatum with significant apoptosis and gliosis, and reduced homovanillic acid levels in midbrain.
 
Human Diseases Modeled Using Mouse Vps13a (1)    Alleles Annotated to Human Diseases(1)   
Gene Ontology
(GO)
classifications
All GO classifications: (7 annotations)
Process locomotory behavior, nervous system development, ...
Component dense core granule
Function molecular_function
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (47)    Tissues (29)    Images (18)
Theiler Stages: 19, 23, 28
Assay TypeResults
RNA in situ 47
cDNA source data(73)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress
Molecular
reagents
All nucleic(75) cDNA(75)
Microarray probesets(8)
Other database
links
Ensembl Gene ModelENSMUSG00000046230 (Evidence)
Entrez Gene271564 (Evidence)
UniGene211963
DFCITC1580817, TC1603652, TC1606130, TC1611244, TC1624604, TC1662241, TC1673813, TC1675599, TC1716205
DoTSDT.101320825, DT.101358001, DT.101702852, DT.101712061, DT.101715726, DT.110861144, DT.40145133, DT.40151365, DT.524294, DT.55232405, DT.94129921
NIA Mouse Gene IndexU038891
Consensus CDS ProjectCCDS37929.1
International Mouse Knockout Project StatusVps13a
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000046230 Ensembl Gene Model | MGI Sequence Detail 164060 C57BL/6J ±  kb
transcript ENSMUST00000068156 Ensembl | MGI Sequence Detail 9656 Not Applicable 
polypeptide ENSMUSP00000068716 Ensembl | MGI Sequence Detail 3166 Not Applicable 

For the selected sequences
All sequences(84) RefSeq(10) UniProt(10)
Polymorphisms SNPs within 2kb(1280 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR015412 Autophagy-related, C-terminal
InterPro IPR026847 Vacuolar protein sorting-associated protein 13
InterPro IPR026854 Vacuolar protein sorting-associated protein 13A N-terminal domain
InterPro IPR009543 Vacuolar protein sorting-associated protein 13 domain
Protein Ontology PR:000017319 vacuolar protein sorting-associated protein 13A
References (Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:182594 Hayashi T, et al., Subcellular localization and putative role of VPS13A/chorein in dopaminergic neuronal cells. Biochem Biophys Res Commun. 2012 Mar 16;419(3):511-6
All references(33)
Other
accession IDs
MGI:1922380, MGI:1926182

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory