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G2e3 Gene Detail
Summary
  • Symbol
    G2e3
  • Name
    G2/M-phase specific E3 ubiquitin ligase
  • Synonyms
    6030408C04Rik, D930034K21Rik, mKIAA1333
  • Feature Type
    protein coding gene
  • IDs
    MGI:2444298
    NCBI Gene: 217558
  • Gene Overview
    MyGene.info: G2E3
Location & Maps
more
  • Sequence Map
    Chr12:51348061-51376986 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      28926 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 12, 22.11 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    G2E3, G2/M-phase specific E3 ubiquitin protein ligase
  • Vertebrate Orthologs
    10
  • Human Ortholog
    G2E3, G2/M-phase specific E3 ubiquitin protein ligase
    Orthology source: HGNC, HomoloGene
  • Synonyms
    KIAA1333, PHF7B
  • Links
    NCBI Gene ID: 55632
    neXtProt AC: NX_Q7L622

  • Chr Location
    14q12; chr14:30559123-30619840 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 32362
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: G2E3
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    35
  • Chemically induced (other)
    1
  • Gene trapped
    34
  • Genomic Mutations
    1 involving G2e3
  • Incidental Mutations
Embryos homozygous for a gene trap allele that inactivates this gene die prior to implantation due to massive apoptosis which results in involution of the blastocyst.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000031423 VEGA Gene Model | MGI Sequence Detail 28926 C57BL/6J ±  kb
transcript OTTMUST00000077856 VEGA | MGI Sequence Detail 2926 Not Applicable  
polypeptide OTTMUSP00000041271 VEGA | MGI Sequence Detail 739 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    343 from dbSNP Build 142
Protein
Information
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Molecular
Reagents
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  • All nucleic 16
    cDNA 15
    Primer pair 1

    Microarray probesets 8
Other
Accession IDs
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MGI:2144993, MGI:2444867
References
more
  • Summaries
    All 31
    Developmental Gene Expression 2
    Gene Ontology 4
    Phenotypes 8
  • Earliest
    J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
  • Latest
    J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory