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Coro2b Gene Detail
Summary
  • Symbol
    Coro2b
  • Name
    coronin, actin binding protein, 2B
  • Synonyms
    E130012P22Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2444283
    NCBI Gene: 235431
  • Alliance
    gene page
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:62419492-62537044 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 33.71 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1083 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2444283
 protein coding gene Chr9:62419490-62537044 (-)
129S1/SvImJ MGP_129S1SvImJ_G0034921
 protein coding gene Chr9:61962498-62074296 (-)
A/J MGP_AJ_G0034901
 protein coding gene Chr9:59922770-60033702 (-)
AKR/J MGP_AKRJ_G0034831
 protein coding gene Chr9:61307583-61419697 (-)
BALB/cJ MGP_BALBcJ_G0034894
 protein coding gene Chr9:59640714-59754079 (-)
C3H/HeJ MGP_C3HHeJ_G0034604
 protein coding gene Chr9:61808976-61922275 (-)
C57BL/6NJ MGP_C57BL6NJ_G0035413
 protein coding gene Chr9:63644329-63779100 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0032324
 protein coding gene Chr9:59592680-59705367 (-)
CAST/EiJ MGP_CASTEiJ_G0033925
 protein coding gene Chr9:61920564-62076968 (-)
CBA/J MGP_CBAJ_G0034575
 protein coding gene Chr9:65824949-65953020 (-)
DBA/2J MGP_DBA2J_G0034734
 protein coding gene Chr9:59723110-59835920 (-)
FVB/NJ MGP_FVBNJ_G0034676
 protein coding gene Chr9:59004630-59117089 (-)
LP/J MGP_LPJ_G0034817
 protein coding gene Chr9:62251801-62366277 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0034719
 protein coding gene Chr9:67226318-67345735 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0035435
 protein coding gene Chr9:61375025-61488419 (-)
PWK/PhJ MGP_PWKPhJ_G0033629
 protein coding gene Chr9:59811338-59955893 (-)
SPRET/EiJ MGP_SPRETEiJ_G0033462
 protein coding gene Chr9:61645556-61796663 (-)
WSB/EiJ MGP_WSBEiJ_G0034038
 protein coding gene Chr9:61299719-61413068 (-)



Homology
more
  • Human Ortholog
    CORO2B, coronin 2B
  • Vertebrate Orthologs
    9
  • Human Ortholog
    CORO2B, coronin 2B
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CLIPINC
  • Links
    NCBI Gene ID: 10391
    neXtProt AC: NX_Q9UQ03
    UniProt: Q9UQ03

  • Chr Location
    15q23; chr15:68518373-68727806 (+)  GRCh38.p7
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotypes from 4 alleles in 4 genetic backgrounds
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous knockout reduces susceptibility to Doxorubicin-induced focal segmental glomerulosclerosis with lower levels of proteinuria and less renal glomerulus damage.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    19
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    634
  • Tissues
    3
  • cDNA Data
    67
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000041729 Ensembl Gene Model | MGI Sequence Detail 117553 C57BL/6J ±  kb
    transcript ENSMUST00000048043 Ensembl | MGI Sequence Detail 3610 Not Applicable  
    polypeptide ENSMUSP00000041826 Ensembl | MGI Sequence Detail 480 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 69
      cDNA 67
      Other 2

      Microarray probesets 4
    References
    more
    • Summaries
      All 33
      Developmental Gene Expression 3
      Gene Ontology 4
      Phenotypes 10
    • Earliest
      J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
    • Latest
      J:279853 Schwarz A, et al., Coro2b, a podocyte protein downregulated in human diabetic nephropathy, is involved in the development of protamine sulphate-induced foot process effacement. Sci Rep. 2019 Jun 20;9(1):8888
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    01/12/2021
    MGI 6.16     		The Jackson Laboratory