Coro2b Gene Detail

Summary

• Symbol
  Coro2b
• Name
  coronin, actin binding protein, 2B
• Synonyms
  E130012P22Rik

• Feature Type
  protein coding gene
• IDs
  MGI:2444283
  NCBI Gene: 235431

Location & Maps

• Sequence Map
  Chr9:62419492-62537044 bp, - strand
• From VEGA annotation of GRCm38
  

  Mouse Genome Browser
  
  

• Download
  Sequence
    117553 bp   ±  kb flank
  
  
• Genome Browsers
  VEGA | Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 9, 33.71 cM
• Mapping Data
  2 experiments

Homology

• Human Ortholog
  CORO2B, coronin 2B

• Vertebrate Orthologs
  9

• Human Ortholog
  CORO2B, coronin 2B
  Orthology source: HomoloGene, HGNC
• Synonyms
  CLIPINC
• Links
  HGNC:2256

  NCBI Gene ID: 10391

  neXtProt AC: NX_Q9UQ03

  
  
• Chr Location
  15q23; chr15:68559275-68727806 (+)  GRCh38.p2

---

• HomoloGene
  Vertebrate Homology Class 21228
  1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed
  
• HCOP
  human homology predictions: CORO2B
• Gene Tree
  Coro2b
  

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  6 phenotype references
  

• All Mutations and Alleles
  38
• Gene trapped
  37
• Targeted
  1
• Incidental Mutations
  Mutagenetix , APF , CvDC

Gene Ontology
(GO)
Classifications

• All GO Annotations
  7
• GO References
  3

• External Resources
  FuncBase

Expression

• cDNA Data
  66
• Literature Summary
  2

• Other Mouse Links
  Allen Institute
  GEO
• Other Vertebrate Links
  Xenbase coro2b

Interactions

• Coro2b interacts with 247 markers (Mir17, Mir19b-1, Mir19b-2, ...) View All

Sequences &
Gene Models

• All Sequences
  58
• RefSeq
  14
• UniProt
  5
• CCDS
  CCDS23264.2
• UniGene
  335229

• VEGA
  OTTMUSG00000023697 (Evidence)
• Ensembl
  ENSMUSG00000041729 (Evidence)
• NCBI Gene
  235431

Representative Sequences			Length	Strain/Species
genomic	OTTMUSG00000023697	VEGA Gene Model | MGI Sequence Detail	117553	C57BL/6J
transcript	OTTMUST00000057868	VEGA | MGI Sequence Detail	3610	Not Applicable
polypeptide	OTTMUSP00000027979	VEGA | MGI Sequence Detail	480	Not Applicable

Polymorphisms

• SNPs within 2kb
  1083 from dbSNP Build 142

Protein
Information

• UniProt
  5 Sequences
• Protein Ontology
  PR:000005764 coronin-2B
• InterPro Domains
  IPR015505 Coronin
  IPR027339 Coronin 2B
  IPR015048 Domain of unknown function DUF1899
  IPR001680 WD40 repeat
  IPR019775 WD40 repeat, conserved site
  IPR017986 WD40-repeat-containing domain
  IPR015943 WD40/YVTN repeat-like-containing domain

Molecular
Reagents

• All nucleic 66

  cDNA 66

  
  

  Microarray probesets 4

References

• Summaries
  All 27

  Developmental Gene Expression 2

  Gene Ontology 3

  Phenotypes 6
• Earliest
  J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
• Latest
  J:207835 Suo D, et al., Coronin-1 is a neurotrophin endosomal effector that is required for developmental competition for survival. Nat Neurosci. 2014 Jan;17(1):36-45