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Islr2
Gene Detail
Symbol

Name
ID
Islr2
immunoglobulin superfamily containing leucine-rich repeat 2
MGI:2444277
Synonyms
B930052A04Rik, Linx, mbu-3, mKIAA1465
Feature Type
protein coding gene
Genetic Map
Chromosome 9
31.63 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr9:58196298-58204319 bp, - strand
From Ensembl annotation of GRCm38

  8022 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:10833  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Islr2

Human
homologs
Human Homolog ISLR2, immunoglobulin superfamily containing leucine-rich repeat 2
NCBI Gene ID 57611
neXtProt AC  NX_Q6UXK2
Human Synonyms  LINX
Human Chr (Location)  15q24.1; chr15:74129374-74136802 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Gene trapped(1) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit perinatal lethality, absent tail pinch response, and defective peroneal and tibial nerve morphology and branch extension.
 
Interactions
Islr2 interacts with 127 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (8 annotations)
Process multicellular organismal development, nervous system development, ...
Component cell surface, integral component of membrane, ...
Function protein binding
External Resources: FuncBase
Expression
Literature Summary: (11 records)
Data Summary: Results (200)    Tissues (172)    Images (45)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 200
cDNA source data(107)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(110) cDNA(108) Primer pair(2)
Microarray probesets(4)
Other database
links
Ensembl Gene ModelENSMUSG00000051243 (Evidence)
Entrez Gene320563 (Evidence)
UniGene186499
DFCITC1577111, TC1602719, TC1655154, TC1667317, TC1709212
DoTSDT.101218242, DT.101277034, DT.101369883, DT.101399636, DT.101399641, DT.91314591, DT.94191756, DT.97364903
NIA Mouse Gene IndexU030935
Consensus CDS ProjectCCDS23238.1, CCDS52812.1
International Mouse Knockout Project StatusIslr2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000051243 Ensembl Gene Model | MGI Sequence Detail 8022 C57BL/6J ±  kb
transcript ENSMUST00000163200 Ensembl | MGI Sequence Detail 4122 Not Applicable 
polypeptide ENSMUSP00000130879 Ensembl | MGI Sequence Detail 789 Not Applicable 

For the selected sequences
All sequences(76) RefSeq(28) UniProt(2)
Polymorphisms
SNPs within 2kb(28 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000483 Cysteine-rich flanking region, C-terminal
InterPro IPR007110 Immunoglobulin-like domain
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR003599 Immunoglobulin subtype
InterPro IPR001611 Leucine-rich repeat
InterPro IPR000372 Leucine-rich repeat-containing N-terminal
InterPro IPR003591 Leucine-rich repeat, typical subtype
Protein Ontology PR:000030678 immunoglobulin superfamily containing leucine-rich repeat protein 2
References
(Earliest) J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
(Latest) J:210221 Mandai K, et al., Linx Mediates Interaxonal Interactions and Formation of the Internal Capsule. Neuron. 2014 Jun 11;
All references(40)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory