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Map3k13 Gene Detail
Summary
  • Symbol
    Map3k13
  • Name
    mitogen-activated protein kinase kinase kinase 13
  • Synonyms
    C130026N12Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2444243
    NCBI Gene: 71751
  • Gene Overview
    MyGene.info: MAP3K13
  • Alliance
Location &
Maps
more
  • Sequence Map
    Chr16:21825170-21933439 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 16, 12.92 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    582 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2444243
protein coding gene Chr16:21794346-21933439 (+)
129S1/SvImJ MGP_129S1SvImJ_G0022662
protein coding gene Chr16:19346620-19392482 (+)
A/J MGP_AJ_G0022624
protein coding gene Chr16:18415522-18455366 (+)
AKR/J MGP_AKRJ_G0022599
protein coding gene Chr16:19188050-19228062 (+)
BALB/cJ MGP_BALBcJ_G0022628
protein coding gene Chr16:18613960-18654224 (+)
C3H/HeJ MGP_C3HHeJ_G0022393
protein coding gene Chr16:19288070-19330893 (+)
C57BL/6NJ MGP_C57BL6NJ_G0023079
protein coding gene Chr16:19749486-19794690 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0020597
protein coding gene Chr16:19119708-19158792 (+)
CAST/EiJ MGP_CASTEiJ_G0021923
protein coding gene Chr16:19276120-19315344 (+)
CBA/J MGP_CBAJ_G0022365
protein coding gene Chr16:20574613-20617300 (+)
DBA/2J MGP_DBA2J_G0022497
protein coding gene Chr16:18400836-18441279 (+)
FVB/NJ MGP_FVBNJ_G0022472
protein coding gene Chr16:18371424-18411046 (+)
LP/J MGP_LPJ_G0022564
protein coding gene Chr16:19093382-19141460 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0022492
protein coding gene Chr16:20170888-20217970 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0023090
protein coding gene Chr16:19131737-19171462 (+)
PWK/PhJ MGP_PWKPhJ_G0021663
protein coding gene Chr16:18634711-18675557 (+)
SPRET/EiJ MGP_SPRETEiJ_G0021493
protein coding gene Chr16:18912895-18956190 (+)
WSB/EiJ MGP_WSBEiJ_G0021966
protein coding gene Chr16:19095053-19141108 (+)



Homology
more
  • Human Ortholog
    MAP3K13, mitogen-activated protein kinase kinase kinase 13
  • Vertebrate Orthologs
    10
  • Human Ortholog
    MAP3K13, mitogen-activated protein kinase kinase kinase 13
    Orthology source: HomoloGene, HGNC
  • Synonyms
    LZK, MEKK13, MLK
  • Links
    NCBI Gene ID: 9175
    neXtProt AC: NX_O43283
    UniProt: O43283

  • Chr Location
    3q27.2; chr3:185282938-185489094 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 71751 NCBI Gene Model | MGI Sequence Detail 108270 C57BL/6J ±  kb
    transcript NM_172821 RefSeq | MGI Sequence Detail 6709 C57BL/6  
    polypeptide Q1HKZ5 UniProt | EBI | MGI Sequence Detail 959 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      1 Sequence
    • Protein Ontology
      PR:000010132 mitogen-activated protein kinase kinase kinase 13
    • EC
    • InterPro Domains
      IPR017419 Mitogen-activated protein kinase kinase kinase 12/13
      IPR027258 Mitogen-activated protein kinase kinase kinase 13
      IPR000719 Protein kinase domain
      IPR011009 Protein kinase-like domain superfamily
      IPR008271 Serine/threonine-protein kinase, active site
      IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domain
    Molecular
    Reagents
    less
    • All nucleic 6
      cDNA 6

      Microarray probesets 1
    References
    more
    • Summaries
      All 27
      Developmental Gene Expression 3
      Gene Ontology 5
      Phenotypes 7
    • Earliest
      J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
    • Latest
      J:260350 Chen M, et al., Leucine Zipper-Bearing Kinase Is a Critical Regulator of Astrocyte Reactivity in the Adult Mammalian CNS. Cell Rep. 2018 Mar 27;22(13):3587-3597

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    last database update
    10/08/2019
    MGI 6.14
    The Jackson Laboratory