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Ccar2 Gene Detail
Summary
  • Symbol
    Ccar2
  • Name
    cell cycle activator and apoptosis regulator 2
  • Synonyms
    2610301G19Rik, Dbc1, mKIAA1967
  • Feature Type
    protein coding gene
  • IDs
    MGI:2444228
    NCBI Gene: 219158
  • Gene Overview
    MyGene.info: CCAR2
Location & Maps
more
  • Sequence Map
    Chr14:70138177-70153811 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      15635 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 14, 36.24 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    CCAR2, cell cycle and apoptosis regulator 2
  • Vertebrate Orthologs
    7
  • Human Ortholog
    CCAR2, cell cycle and apoptosis regulator 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    DBC1, DBC-1, KIAA1967, NET35, p30DBC, p30 DBC
  • Links
    NCBI Gene ID: 57805
    neXtProt AC: NX_Q8N163

  • Chr Location
    8p21.3; chr8:22604632-22620471 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    15 phenotypes from 2 alleles in 2 genetic backgrounds
    7 phenotypes from multigenic genotypes
    1 images
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    8
  • Chemically induced (other)
    1
  • Gene trapped
    5
  • Targeted
    2
  • Genomic Mutations
    1 involving Ccar2
  • Incidental Mutations
Homozygous null mice on a high fat diet are resistant to hepatic steatosis and associated liver inflammation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000033712 Ensembl Gene Model | MGI Sequence Detail 15635 C57BL/6J ±  kb
transcript ENSMUST00000035612 Ensembl | MGI Sequence Detail 3716 Not Applicable  
polypeptide ENSMUSP00000036924 Ensembl | MGI Sequence Detail 922 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    87 from dbSNP Build 142
Protein
Information
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  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000039818 cell cycle and apoptosis regulator protein 2
  • InterPro Domains
    IPR025224 Cell cycle and apoptosis regulator protein
    IPR028811 Cell cycle and apoptosis regulator protein 2
    IPR025954 DBC1/CARP1 catalytically inactive NUDIX hydrolase domain
    IPR011992 EF-hand domain pair
    IPR025223 S1-like RNA binding domain
Molecular
Reagents
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  • All nucleic 71
    cDNA 71

    Microarray probesets 3
References
more
  • Summaries
    All 35
    Developmental Gene Expression 1
    Gene Ontology 6
    Phenotypes 14
  • Earliest
    J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
  • Latest
    J:230114 Escande C, et al., Deleted in breast cancer 1 limits adipose tissue fat accumulation and plays a key role in the development of metabolic syndrome phenotype. Diabetes. 2015 Jan;64(1):12-22

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory