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Bhlha9 Gene Detail
Summary
  • Symbol
    Bhlha9
  • Name
    basic helix-loop-helix family, member a9
  • Synonyms
    A830053O21Rik, Fingerin
  • Feature Type
    protein coding gene
  • IDs
    MGI:2444198
    NCBI Gene: 320522
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:76563296-76564502 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 11, 45.97 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    22 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2444198
protein coding gene Chr11:76563296-76564502 (+)
129S1/SvImJ MGP_129S1SvImJ_G0018736
protein coding gene Chr11:77515428-77516634 (+)
A/J MGP_AJ_G0018702
protein coding gene Chr11:74616572-74617778 (+)
AKR/J MGP_AKRJ_G0018672
protein coding gene Chr11:76878618-76879824 (+)
BALB/cJ MGP_BALBcJ_G0018676
protein coding gene Chr11:74994983-74996189 (+)
C3H/HeJ MGP_C3HHeJ_G0018489
protein coding gene Chr11:76896956-76898162 (+)
C57BL/6NJ MGP_C57BL6NJ_G0019127
protein coding gene Chr11:79960700-79961906 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0016762
protein coding gene Chr11:71608229-71609433 (+)
CAST/EiJ MGP_CASTEiJ_G0018043
protein coding gene Chr11:77294001-77295207 (+)
CBA/J MGP_CBAJ_G0018459
protein coding gene Chr11:83454742-83455948 (+)
DBA/2J MGP_DBA2J_G0018568
protein coding gene Chr11:74209908-74211114 (+)
FVB/NJ MGP_FVBNJ_G0018558
protein coding gene Chr11:73762606-73763812 (+)
LP/J MGP_LPJ_G0018639
protein coding gene Chr11:78088272-78089478 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0018584
protein coding gene Chr11:83907606-83908812 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0019167
protein coding gene Chr11:77071078-77072284 (+)
PWK/PhJ MGP_PWKPhJ_G0017814
protein coding gene Chr11:74945799-74947005 (+)
SPRET/EiJ MGP_SPRETEiJ_G0017605
protein coding gene Chr11:76649735-76650936 (+)
WSB/EiJ MGP_WSBEiJ_G0018096
protein coding gene Chr11:76903231-76904437 (+)



Homology
more
  • Human Ortholog
    BHLHA9, basic helix-loop-helix family member a9
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    BHLHA9, basic helix-loop-helix family member a9
  • Synonyms
    BHLHF42, CCSPD
  • Links
    NCBI Gene ID: 727857
    neXtProt AC: NX_Q7RTU4
    UniProt: Q7RTU4

  • Chr Location
    17p13.3; chr17:1270444-1271815 (+)  GRCh38

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotypes from 2 alleles in 2 genetic backgrounds
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit variable asymmetrical syndactyly and interdigital webbing due to reduced interdigital apoptosis and incomplete separation of soft, but not skeletal, tissues between forelimb digits 2 and 3.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 320522 NCBI Gene Model | MGI Sequence Detail 1207 C57BL/6J ±  kb
    transcript NM_177182 RefSeq | MGI Sequence Detail 1225 Not Specified  
    polypeptide Q5RJB0 UniProt | EBI | MGI Sequence Detail 231 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      1 Sequence
    • Protein Ontology
      PR:000032308 class A basic helix-loop-helix protein 9
    • InterPro Domains
      IPR036638 Helix-loop-helix DNA-binding domain superfamily
      IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
    Molecular
    Reagents
    less
    • All nucleic 11
      cDNA 8
      Primer pair 2
      Other 1

      Microarray probesets 2
    References
    more
    • Summaries
      All 40
      Developmental Gene Expression 9
      Gene Ontology 4
      Phenotypes 15
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:287575 Bohic M, et al., Loss of bhlha9 Impairs Thermotaxis and Formalin-Evoked Pain in a Sexually Dimorphic Manner. Cell Rep. 2020 Jan 21;30(3):602-610.e6

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    last database update
    03/12/2024
    MGI 6.23
    The Jackson Laboratory