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Dgkh Gene Detail
Summary
  • Symbol
    Dgkh
  • Name
    diacylglycerol kinase, eta
  • Synonyms
    5930402B05Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2444188
    NCBI Gene: 380921
  • Alliance
  • Transcription Start Sites
    21 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:78796789-78970169 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 14, 41.56 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1568 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2444188
protein coding gene Chr14:78796190-78970216 (-)
129S1/SvImJ MGP_129S1SvImJ_G0021591
protein coding gene Chr14:73637054-73804330 (-)
A/J MGP_AJ_G0021549
protein coding gene Chr14:71847548-72016162 (-)
AKR/J MGP_AKRJ_G0021526
protein coding gene Chr14:73986694-74165183 (-)
BALB/cJ MGP_BALBcJ_G0021556
protein coding gene Chr14:71671617-71847017 (-)
C3H/HeJ MGP_C3HHeJ_G0021333
protein coding gene Chr14:73706061-73880230 (-)
C57BL/6NJ MGP_C57BL6NJ_G0021996
protein coding gene Chr14:76764084-76960620 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019534
protein coding gene Chr14:69423803-69584826 (-)
CAST/EiJ MGP_CASTEiJ_G0020850
protein coding gene Chr14:70497196-70673316 (-)
CBA/J MGP_CBAJ_G0021301
protein coding gene Chr14:79213218-79424205 (-)
DBA/2J MGP_DBA2J_G0021424
protein coding gene Chr14:71253726-71417084 (-)
FVB/NJ MGP_FVBNJ_G0021402
protein coding gene Chr14:70585608-70753874 (-)
LP/J MGP_LPJ_G0021494
protein coding gene Chr14:74745609-74927469 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0021429
protein coding gene Chr14:77874222-78072949 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0022019
protein coding gene Chr14:73272308-73434604 (-)
PWK/PhJ MGP_PWKPhJ_G0020593
protein coding gene Chr14:68022390-68203519 (-)
SPRET/EiJ MGP_SPRETEiJ_G0020430
protein coding gene Chr14:69276680-69462434 (-)
WSB/EiJ MGP_WSBEiJ_G0020903
protein coding gene Chr14:73621751-73801229 (-)



Homology
more
  • Human Ortholog
    DGKH, diacylglycerol kinase eta
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DGKH, diacylglycerol kinase eta
  • Synonyms
    DGKeta
  • Links
    NCBI Gene ID: 160851
    neXtProt AC: NX_Q86XP1
    UniProt: Q86XP1

  • Chr Location
    13q14.11; chr13:42040036-42256584 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 3 alleles in 3 genetic backgrounds
    8 phenotypes from multigenic genotypes
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit hyperactivity, decreased anxiety-related behaviors, and impaired spatial learning and memory.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 380921 NCBI Gene Model | MGI Sequence Detail 173381 C57BL/6J ±  kb
    transcript NR_104044 RefSeq | MGI Sequence Detail 14726 C57BL/6  
    polypeptide D3YXJ0 UniProt | EBI | MGI Sequence Detail 1211 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 12
      cDNA 10
      Primer pair 2

      Microarray probesets 2
    References
    more
    • Summaries
      All 41
      Developmental Gene Expression 5
      Gene Ontology 6
      Phenotypes 13
    • Earliest
      J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
    • Latest
      J:325757 Asami M, et al., Dopamine and the phosphorylated dopamine transporter are increased in the diacylglycerol kinase eta-knockout mouse brain. FEBS Lett. 2021 May;595(9):1313-1321

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    last database update
    11/22/2022
    MGI 6.22
    The Jackson Laboratory