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Dgkh Gene Detail
Summary
  • Symbol
    Dgkh
  • Name
    diacylglycerol kinase, eta
  • Synonyms
    5930402B05Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2444188
    NCBI Gene: 380921
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:78559349-78732729 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 14, 41.56 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1578 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2444188
protein coding gene Chr14:78558750-78732776 (-)
129S1/SvImJ MGP_129S1SvImJ_G0021591
protein coding gene Chr14:73637054-73804330 (-)
A/J MGP_AJ_G0021549
protein coding gene Chr14:71847548-72016162 (-)
AKR/J MGP_AKRJ_G0021526
protein coding gene Chr14:73986694-74165183 (-)
BALB/cJ MGP_BALBcJ_G0021556
protein coding gene Chr14:71671617-71847017 (-)
C3H/HeJ MGP_C3HHeJ_G0021333
protein coding gene Chr14:73706061-73880230 (-)
C57BL/6NJ MGP_C57BL6NJ_G0021996
protein coding gene Chr14:76764084-76960620 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019534
protein coding gene Chr14:69423803-69584826 (-)
CAST/EiJ MGP_CASTEiJ_G0020850
protein coding gene Chr14:70497196-70673316 (-)
CBA/J MGP_CBAJ_G0021301
protein coding gene Chr14:79213218-79424205 (-)
DBA/2J MGP_DBA2J_G0021424
protein coding gene Chr14:71253726-71417084 (-)
FVB/NJ MGP_FVBNJ_G0021402
protein coding gene Chr14:70585608-70753874 (-)
LP/J MGP_LPJ_G0021494
protein coding gene Chr14:74745609-74927469 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0021429
protein coding gene Chr14:77874222-78072949 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0022019
protein coding gene Chr14:73272308-73434604 (-)
PWK/PhJ MGP_PWKPhJ_G0020593
protein coding gene Chr14:68022390-68203519 (-)
SPRET/EiJ MGP_SPRETEiJ_G0020430
protein coding gene Chr14:69276680-69462434 (-)
WSB/EiJ MGP_WSBEiJ_G0020903
protein coding gene Chr14:73621751-73801229 (-)



Homology
more
  • Human Ortholog
    DGKH, diacylglycerol kinase eta
  • Vertebrate Orthologs
    10
  • Human Ortholog
    DGKH, diacylglycerol kinase eta
    Orthology source: HomoloGene, HGNC
  • Synonyms
    DGKeta
  • Links
    NCBI Gene ID: 160851
    neXtProt AC: NX_Q86XP1
    UniProt: Q86XP1

  • Chr Location
    13q14.11; chr13:42040036-42256584 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 99373
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: DGKH
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 380921 NCBI Gene Model | MGI Sequence Detail 173381 C57BL/6J ±  kb
transcript NR_104044 RefSeq | MGI Sequence Detail 14726 C57BL/6  
polypeptide NP_001074805 RefSeq | MGI Sequence Detail 1180 C57BL/6  
For the selected sequence
Protein
Information
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  • UniProt
    6 Sequences
  • EC
  • InterPro Domains
    IPR037607 Diacylglycerol kinase
    IPR000756 Diacylglycerol kinase, accessory domain
    IPR001206 Diacylglycerol kinase, catalytic domain
    IPR017438 Inorganic polyphosphate/ATP-NAD kinase, N-terminal
    IPR016064 NAD kinase/diacylglycerol kinase-like domain superfamily
    IPR011993 PH-like domain superfamily
    IPR001849 Pleckstrin homology domain
    IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
    IPR001660 Sterile alpha motif domain
    IPR013761 Sterile alpha motif/pointed domain superfamily
Molecular
Reagents
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  • All nucleic 12
    cDNA 10
    Primer pair 2

    Microarray probesets 2
References
more
  • Summaries
    All 30
    Developmental Gene Expression 4
    Gene Ontology 3
    Phenotypes 8
  • Earliest
    J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
  • Latest
    J:218160 Shionoya T, et al., Distinct expression and localization of the type II diacylglycerol kinase isozymes inverted question mark, inverted question mark and inverted question mark in the mouse reproductive organs. BMC Dev Biol. 2015 Jan 23;15(1):6

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
11/26/2019
MGI 6.14
The Jackson Laboratory