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Lmod3 Gene Detail
Summary
  • Symbol
    Lmod3
  • Name
    leiomodin 3 (fetal)
  • Synonyms
    5430424A14Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2444169
    NCBI Gene: 320502
  • Gene Overview
    MyGene.info: LMOD3
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr6:97238534-97252759 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      14226 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 44.92 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    LMOD3, leiomodin 3
  • Vertebrate Orthologs
    10
  • Human Ortholog
    LMOD3, leiomodin 3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    NEM10
  • Links
    NCBI Gene ID: 56203
    neXtProt AC: NX_Q0VAK6
    UniProt: Q0VAK6

  • Chr Location
    3p14.1; chr3:69108672-69122595 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 28097
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: LMOD3
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with Lmod3 mouse models; 1 with human LMOD3 associations

Human Disease Mouse Models
      
IDs
View 2 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    16 phenotypes from 2 alleles in 2 genetic backgrounds
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for an endonuclease-mediated mutation are runted and exhibit nemaline myopathy including a reduction in skeletal myofiber size, centrally nucleated skeletal muscle fibers, increase in skeletal muscle glycogen levels, and abnormal sarcomere and Z lines.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000057822 VEGA Gene Model | MGI Sequence Detail 14226 C57BL/6J ±  kb
transcript OTTMUST00000141980 VEGA | MGI Sequence Detail 2215 Not Applicable  
polypeptide OTTMUSP00000074125 VEGA | MGI Sequence Detail 571 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    129 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 10
    cDNA 10

    Microarray probesets 2
References
more
  • Summaries
    All 32
    Developmental Gene Expression 7
    Diseases 2
    Gene Ontology 7
    Phenotypes 6
  • Earliest
    J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
  • Latest
    J:255305 Ramirez-Martinez A, et al., KLHL41 stabilizes skeletal muscle sarcomeres by nonproteolytic ubiquitination. Elife. 2017 Aug 9;6(None):None

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/03/2018
MGI 6.11
The Jackson Laboratory