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Lmod3 Gene Detail
Summary
  • Symbol
    Lmod3
  • Name
    leiomodin 3 (fetal)
  • Synonyms
    5430424A14Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2444169
    NCBI Gene: 320502
  • Alliance
    gene page
  • Transcription Start Sites
    12 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:97215495-97229720 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 44.92 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    124 from dbSNP Build 142
  • Strain Annotations
    17
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2444169
 protein coding gene Chr6:97215491-97230137 (-)
129S1/SvImJ MGP_129S1SvImJ_G0031076
 protein coding gene Chr6:99069611-99083583 (-)
A/J MGP_AJ_G0031045
 protein coding gene Chr6:95325169-95339620 (-)
AKR/J MGP_AKRJ_G0030976
 protein coding gene Chr6:97946985-97965868 (-)
BALB/cJ MGP_BALBcJ_G0031056
 protein coding gene Chr6:95285371-95300305 (-)
C3H/HeJ MGP_C3HHeJ_G0030652
 protein coding gene Chr6:86470792-86485937 (+)
C57BL/6NJ MGP_C57BL6NJ_G0031515
 protein coding gene Chr6:101586084-101600084 (-)
CAROLI/EiJ no annotation
CAST/EiJ MGP_CASTEiJ_G0030163
 protein coding gene Chr6:98123452-98139954 (-)
CBA/J MGP_CBAJ_G0030742
 protein coding gene Chr6:105462331-105477818 (-)
DBA/2J MGP_DBA2J_G0030895
 protein coding gene Chr6:94466324-94480392 (-)
FVB/NJ MGP_FVBNJ_G0030849
 protein coding gene Chr6:93646294-93660194 (-)
LP/J MGP_LPJ_G0030975
 protein coding gene Chr6:99105970-99121355 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030883
 protein coding gene Chr6:109368812-109384454 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0031542
 protein coding gene Chr6:97818819-97833569 (-)
PWK/PhJ MGP_PWKPhJ_G0029879
 protein coding gene Chr6:93443831-93458410 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029707
 protein coding gene Chr6:96718824-96732026 (-)
WSB/EiJ MGP_WSBEiJ_G0030247
 protein coding gene Chr6:98282657-98299015 (-)



Homology
more
  • Human Ortholog
    LMOD3, leiomodin 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    LMOD3, leiomodin 3
  • Synonyms
    NEM10
  • Links
    NCBI Gene ID: 56203
    neXtProt AC: NX_Q0VAK6
    UniProt: Q0VAK6

  • Chr Location
    3p14.1; chr3:69106065-69123032 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Lmod3 mouse models; 1 with human LMOD3 associations

Human Disease Mouse Models
      
IDs
 View 2 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    54 phenotypes from 3 alleles in 3 genetic backgrounds
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for an endonuclease-mediated mutation are runted and exhibit nemaline myopathy including a reduction in skeletal myofiber size, centrally nucleated skeletal muscle fibers, increase in skeletal muscle glycogen levels, and abnormal sarcomere and Z lines.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    26
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1009
  • Tissues
    51
  • cDNA Data
    12
  • Literature Summary
    9
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000044086 Ensembl Gene Model | MGI Sequence Detail 14226 C57BL/6J ±  kb
    transcript ENSMUST00000095655 Ensembl | MGI Sequence Detail 2215 Not Applicable  
    polypeptide ENSMUSP00000093315 Ensembl | MGI Sequence Detail 571 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 15
      cDNA 12
      Primer pair 3

      Microarray probesets 2
    References
    more
    • Summaries
      All 42
      Developmental Gene Expression 9
      Diseases 2
      Gene Ontology 8
      Phenotypes 13
    • Earliest
      J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
    • Latest
      J:325251 Chen A, et al., Spatiotemporal transcriptomic atlas of mouse organogenesis using DNA nanoball-patterned arrays. Cell. 2022 May 12;185(10):1777-1792.e21
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory