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Nmnat2 Gene Detail
Summary
  • Symbol
    Nmnat2
  • Name
    nicotinamide nucleotide adenylyltransferase 2
  • Synonyms
    D030041I09Rik, mKIAA0479, PNAT1
  • Feature Type
    protein coding gene
  • IDs
    MGI:2444155
    NCBI Gene: 226518
  • Gene Overview
    MyGene.info: NMNAT2
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:152954993-153119261 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 65.15 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2027 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2444155
protein coding gene Chr1:152954939-153119266 (.)
129S1/SvImJ MGP_129S1SvImJ_G0016593
protein coding gene Chr1:157739764-157913821 (+)
A/J MGP_AJ_G0016575
protein coding gene Chr1:151382919-151548831 (+)
AKR/J MGP_AKRJ_G0016540
protein coding gene Chr1:156066150-156238773 (+)
BALB/cJ MGP_BALBcJ_G0016535
protein coding gene Chr1:151957185-152116179 (+)
C3H/HeJ MGP_C3HHeJ_G0016360
protein coding gene Chr1:156166523-156339105 (+)
C57BL/6NJ MGP_C57BL6NJ_G0016996
protein coding gene Chr1:163188646-163371791 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014705
protein coding gene Chr1:143698732-143862747 (+)
CAST/EiJ MGP_CASTEiJ_G0015939
protein coding gene Chr1:155677263-155848909 (+)
CBA/J MGP_CBAJ_G0016334
protein coding gene Chr1:168932089-169131516 (+)
DBA/2J MGP_DBA2J_G0016440
protein coding gene Chr1:150397894-150565649 (+)
FVB/NJ MGP_FVBNJ_G0016438
protein coding gene Chr1:148884791-149050643 (+)
LP/J MGP_LPJ_G0016511
protein coding gene Chr1:158856446-159032414 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0016464
protein coding gene Chr1:176576602-176762407 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0017032
protein coding gene Chr1:155847771-156022797 (+)
PWK/PhJ MGP_PWKPhJ_G0015725
protein coding gene Chr1:149420751-149589800 (+)
SPRET/EiJ MGP_SPRETEiJ_G0015512
protein coding gene Chr1:154654732-154816794 (+)
WSB/EiJ MGP_WSBEiJ_G0016002
protein coding gene Chr1:155907294-156079715 (+)



Homology
more
  • Human Ortholog
    NMNAT2, nicotinamide nucleotide adenylyltransferase 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    NMNAT2, nicotinamide nucleotide adenylyltransferase 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    C1orf15, PNAT2
  • Links
    NCBI Gene ID: 23057
    neXtProt AC: NX_Q9BZQ4
    UniProt: Q9BZQ4

  • Chr Location
    1q25.3; chr1:183248237-183418499 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 75037
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: NMNAT2
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    33 phenotypes from 4 alleles in 3 genetic backgrounds
    6 phenotypes from multigenic genotypes
    6 images
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a gene trap or transposon inserted allele exhibit perinatal lethality, distended bladders, atelectasis and loss of axon integrity.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000042751 Ensembl Gene Model | MGI Sequence Detail 164269 C57BL/6J ±  kb
    transcript ENSMUST00000043313 Ensembl | MGI Sequence Detail 4626 Not Applicable  
    polypeptide ENSMUSP00000041110 Ensembl | MGI Sequence Detail 307 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 58
      cDNA 58

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2138339
    References
    more
    • Summaries
      All 47
      Developmental Gene Expression 4
      Gene Ontology 7
      Phenotypes 17
    • Earliest
      J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
    • Latest
      J:252071 Gilley J, et al., Sarm1 Deletion, but Not Wld(S), Confers Lifelong Rescue in a Mouse Model of Severe Axonopathy. Cell Rep. 2017 Oct 3;21(1):10-16

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory