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Nmnat2
Gene Detail
Symbol

Name
ID
Nmnat2
nicotinamide nucleotide adenylyltransferase 2
MGI:2444155
Synonyms
D030041I09Rik, mKIAA0479, PNAT1
Feature Type
protein coding gene
Genetic Map
Chromosome 1
65.15 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr1:152954993-153119261 bp, + strand
From VEGA annotation of GRCm38

  164269 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:75037  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: NMNAT2
Gene Tree: Nmnat2

Human
homologs
NMNAT2, nicotinamide nucleotide adenylyltransferase 2
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 23057
neXtProt AC: NX_Q9BZQ4

Human Synonyms: C1orf15, PNAT2

Human Chr (Location): 1q25; chr1:183248237-183418499 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(338) : Gene trapped(337) Transposon induced(1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a gene trap or transposon inserted allele exhibit perinatal lethality, distended bladders, atelectasis and loss of axon integrity.
 
Phenotype Images(6)
Interactions
Nmnat2 interacts with 327 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (17 annotations)
Process biosynthetic process, NAD biosynthetic process, ...
Component cytoplasm, Golgi apparatus, ...
Function ATP binding, catalytic activity, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (246)    Tissues (109)    Images (31)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 246
cDNA source data(57)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase nmnat2 ; ZFIN nmnat2    NEW 
Molecular
reagents
All nucleic(57) cDNA(57)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000049702 (Evidence)
Ensembl Gene Model ENSMUSG00000042751 (Evidence)
Entrez Gene 226518 (Evidence)
UniGene 40548
DFCI TC1581093, TC1597711
DoTS DT.101735736, DT.97342002
NIA Mouse Gene Index U000925
EC 2.7.7.18, 2.7.7.1
Consensus CDS Project CCDS15368.1
International Mouse Phenotyping Consortium Status Nmnat2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000049702 VEGA Gene Model | MGI Sequence Detail 164269 C57BL/6J ±  kb
transcript OTTMUST00000126601 VEGA | MGI Sequence Detail 4626 Not Applicable 
polypeptide OTTMUSP00000068437 VEGA | MGI Sequence Detail 307 Not Applicable 

For the selected sequences
All sequences(47) RefSeq(7) UniProt(4)
Polymorphisms
SNPs within 2kb(2039 from dbSNP Build 137)    SNPs within 2kb including multiple locations(2041)
Protein-related
information
ResourceIDDescription
InterPro IPR004821 Cytidyltransferase-like domain
InterPro IPR005248 Probable nicotinate-nucleotide adenylyltransferase
InterPro IPR014729 Rossmann-like alpha/beta/alpha sandwich fold
Protein Ontology PR:000011291 nicotinamide mononucleotide adenylyltransferase 2
References
(Earliest) J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
(Latest) J:206634 Hicks AN, et al., Lack of nicotinamide mononucleotide adenylyltransferase 2 (Nmnat2): consequences for mouse bladder development and function. Neurourol Urodyn. 2013 Nov;32(8):1130-6
All references(39)
Other
accession IDs
MGI:2138339

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory