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Nmnat2
Gene Detail
 Symbol
Name
ID
Nmnat2
nicotinamide nucleotide adenylyltransferase 2
MGI:2444155
Synonyms D030041I09Rik, mKIAA0479, PNAT1
Feature Type protein coding gene
Genetic Map
Chromosome 1
65.15 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr1:152955101-153119260 bp, + strand
From Ensembl annotation of GRCm38

  164160 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:75037  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Nmnat2

Human
homologs
Human Homolog NMNAT2, nicotinamide nucleotide adenylyltransferase 2
NCBI Gene ID 23057
neXtProt AC  NX_Q9BZQ4
Human Synonyms  C1orf15, PNAT2
Human Chr (Location)  1q25; chr1:183248237-183418499 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(338) : Gene trapped(337) Transposon induced(1)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a gene trap or transposon inserted allele exhibit perinatal lethality, distended bladders, atelectasis and loss of axon integrity.
 
Phenotype Images(6)
Interactions
Nmnat2 interacts with 327 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (17 annotations)
Process biosynthetic process, NAD biosynthetic process, ...
Component cytoplasm, Golgi apparatus, ...
Function ATP binding, catalytic activity, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (246)    Tissues (109)    Images (31)
Theiler Stages: 22, 23
Assay TypeResults
RNA in situ 246
cDNA source data(57)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(57) cDNA(57)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000042751 (Evidence)
Entrez Gene226518 (Evidence)
UniGene40548
DFCITC1581093, TC1597711
DoTSDT.101735736, DT.97342002
NIA Mouse Gene IndexU000925
EC2.7.7.1, 2.7.7.18
Consensus CDS ProjectCCDS15368.1
International Mouse Knockout Project StatusNmnat2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000042751 Ensembl Gene Model | MGI Sequence Detail 164160 C57BL/6J ±  kb
transcript ENSMUST00000043313 Ensembl | MGI Sequence Detail 4522 Not Applicable 
polypeptide ENSMUSP00000041110 Ensembl | MGI Sequence Detail 307 Not Applicable 

For the selected sequences
All sequences(28) RefSeq(7) UniProt(2)
Polymorphisms SNPs within 2kb(2037 from dbSNP Build 137)    SNPs within 2kb including multiple locations(2039)
Protein-related
information
ResourceIDDescription
InterPro IPR004821 Cytidyltransferase-like domain
InterPro IPR005248 Probable nicotinate-nucleotide adenylyltransferase
InterPro IPR014729 Rossmann-like alpha/beta/alpha sandwich fold
Protein Ontology PR:000011291 nicotinamide mononucleotide adenylyltransferase 2
References (Earliest) J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
(Latest) J:206634 Hicks AN, et al., Lack of nicotinamide mononucleotide adenylyltransferase 2 (Nmnat2): consequences for mouse bladder development and function. Neurourol Urodyn. 2013 Nov;32(8):1130-6
All references(39)
Other
accession IDs
MGI:2138339

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/23/2014
MGI 5.19
The Jackson Laboratory