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Mars2 Gene Detail
Summary
  • Symbol
    Mars2
  • Name
    methionine-tRNA synthetase 2 (mitochondrial)
  • Synonyms
    C730026E21Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2444136
    NCBI Gene: 212679
Location & Maps
more
  • Sequence Map
    Chr1:55237177-55248470 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      11294 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 28.08 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    MARS2, methionyl-tRNA synthetase 2, mitochondrial
  • Vertebrate Orthologs
    11
  • Human Ortholog
    MARS2, methionyl-tRNA synthetase 2, mitochondrial
    Orthology source: HomoloGene, HGNC
  • Synonyms
    COXPD25, MetRS, mtMetRS
  • Links
    NCBI Gene ID: 92935
    neXtProt AC: NX_Q96GW9

  • Chr Location
    2q33.1; chr2:197705304-197708390 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 6009
    1 human;1 mouse;2 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed
  • HCOP
    human homology predictions: MARS2
  • Gene Tree
Human Diseases
more
  • Diseases
    2 with human MARS2 associations

Human Disease Mouse Models
       Combined Oxidative Phosphorylation Deficiency 25; COXPD25   OMIM: 616430
Spastic Ataxia 3, Autosomal Recessive; SPAX3   OMIM: 611390
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    8 phenotype references
  • All Mutations and Alleles
    5
  • Chemically induced (other)
    1
  • Radiation induced
    1
  • Targeted
    3
  • Genomic Mutations
    2 involving Mars2
  • Incidental Mutations
    APF
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000046972 VEGA Gene Model | MGI Sequence Detail 11294 C57BL/6J ±  kb
transcript OTTMUST00000121723 VEGA | MGI Sequence Detail 11294 Not Applicable  
polypeptide OTTMUSP00000066987 VEGA | MGI Sequence Detail 586 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    75 from dbSNP Build 142
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000010191 methionyl-tRNA synthetase, mitochondrial
  • EC
  • InterPro Domains
    IPR009080 Aminoacyl-tRNA synthetase, class Ia, anticodon-binding
    IPR015413 Methionyl/Leucyl tRNA synthetase
    IPR014758 Methionyl-tRNA synthetase
    IPR014729 Rossmann-like alpha/beta/alpha sandwich fold
Molecular
Reagents
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  • All nucleic 25
    cDNA 24
    Primer pair 1

    Microarray probesets 5
References
more
  • Summaries
    All 28
    Developmental Gene Expression 1
    Gene Ontology 5
    Phenotypes 8
  • Earliest
    J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
  • Latest
    J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
09/27/2016
MGI 6.05
The Jackson Laboratory