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Mars2 Gene Detail
Summary
  • Symbol
    Mars2
  • Name
    methionine-tRNA synthetase 2 (mitochondrial)
  • Synonyms
    C730026E21Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2444136
    NCBI Gene: 212679
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:55276336-55279217 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 1, 28.08 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    36 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2444136
protein coding gene Chr1:55276336-55287629 (+)
129S1/SvImJ MGP_129S1SvImJ_G0016034
protein coding gene Chr1:54971484-54982777 (+)
A/J MGP_AJ_G0016017
protein coding gene Chr1:53052961-53064258 (+)
AKR/J MGP_AKRJ_G0015973
protein coding gene Chr1:54493828-54505123 (+)
BALB/cJ MGP_BALBcJ_G0015972
protein coding gene Chr1:53100820-53112115 (+)
C3H/HeJ MGP_C3HHeJ_G0015804
protein coding gene Chr1:54737057-54748354 (+)
C57BL/6NJ MGP_C57BL6NJ_G0016425
protein coding gene Chr1:57239719-57251012 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014147
protein coding gene Chr1:49140390-49151659 (+)
CAST/EiJ MGP_CASTEiJ_G0015386
protein coding gene Chr1:54021391-54033578 (+)
CBA/J MGP_CBAJ_G0015776
protein coding gene Chr1:58871824-58883121 (+)
DBA/2J MGP_DBA2J_G0015877
protein coding gene Chr1:52474390-52485687 (+)
FVB/NJ MGP_FVBNJ_G0015879
protein coding gene Chr1:51819619-51830916 (+)
LP/J MGP_LPJ_G0015949
protein coding gene Chr1:55794788-55806081 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0015899
protein coding gene Chr1:61961308-61972607 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0016472
protein coding gene Chr1:54442307-54453606 (+)
PWK/PhJ MGP_PWKPhJ_G0015172
protein coding gene Chr1:51837264-51848791 (+)
SPRET/EiJ MGP_SPRETEiJ_G0014953
protein coding gene Chr1:54073198-54086237 (+)
WSB/EiJ MGP_WSBEiJ_G0015449
protein coding gene Chr1:54129421-54140720 (+)



Homology
more
  • Human Ortholog
    MARS2, methionyl-tRNA synthetase 2, mitochondrial
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MARS2, methionyl-tRNA synthetase 2, mitochondrial
  • Synonyms
    COXPD25, MetRS, mtMetRS
  • Links
    NCBI Gene ID: 92935
    neXtProt AC: NX_Q96GW9
    UniProt: Q96GW9

  • Chr Location
    2q33.1; chr2:197705369-197708395 (+)  GRCh38

Human Diseases
more
  • Diseases
    2 with human MARS2 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    14 phenotypes from 1 allele in 2 genetic backgrounds
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit decreased embryo size, a rudimentary egg cylinder, failure of primitive streak formation, absent primitive node and head folds, failure to gastrulate, and complete lethality prior to organogenesis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 212679 NCBI Gene Model | MGI Sequence Detail 2882 C57BL/6J ±  kb
    transcript NM_175439 RefSeq | MGI Sequence Detail 2882 Not Specified  
    polypeptide Q499X9 UniProt | EBI | MGI Sequence Detail 586 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 27
      cDNA 25
      Primer pair 2

      Microarray probesets 5
    References
    more
    • Summaries
      All 36
      Developmental Gene Expression 3
      Gene Ontology 5
      Phenotypes 11
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:290315 Cheong A, et al., Nuclear-encoded mitochondrial ribosomal proteins are required to initiate gastrulation. Development. 2020 May 26;147(10):dev188714

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    last database update
    03/12/2024
    MGI 6.23
    The Jackson Laboratory