Nemp2 MGI Mouse Gene Detail - MGI:2444113 - nuclear envelope integral membrane protein 2

Symbol

Nemp2
Name

nuclear envelope integral membrane protein 2
Synonyms

5330401P04Rik, Tmem194b

Feature Type

protein coding gene
IDs

MGI:2444113
NCBI Gene: 227094
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr1:52669862-52691078 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 26.99 cM
Mapping Data

1 experiment

SNPs within 2kb

330 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2444113	protein coding gene	Chr1:52669850-52691078 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0016009	protein coding gene	Chr1:52149860-52171068 (+)
A/J	MGP_AJ_G0015991	protein coding gene	Chr1:50401880-50423088 (+)
AKR/J	MGP_AKRJ_G0015947	protein coding gene	Chr1:51471292-51492524 (+)
BALB/cJ	MGP_BALBcJ_G0015948	protein coding gene	Chr1:50221523-50243020 (+)
C3H/HeJ	MGP_C3HHeJ_G0015780	protein coding gene	Chr1:51867969-51889193 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0016399	protein coding gene	Chr1:54350617-54371833 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014125	protein coding gene	Chr1:41448889-41467870 (-)
CAST/EiJ	MGP_CASTEiJ_G0015361	protein coding gene	Chr1:51366417-51387623 (+)
CBA/J	MGP_CBAJ_G0015751	protein coding gene	Chr1:55783435-55804648 (+)
DBA/2J	MGP_DBA2J_G0015852	protein coding gene	Chr1:49672936-49694152 (+)
FVB/NJ	MGP_FVBNJ_G0015854	protein coding gene	Chr1:49127251-49148992 (+)
LP/J	MGP_LPJ_G0015923	protein coding gene	Chr1:52631822-52653038 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0015874	protein coding gene	Chr1:58836042-58857271 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0016447	protein coding gene	Chr1:51593669-51614874 (+)
PWK/PhJ	MGP_PWKPhJ_G0015147	protein coding gene	Chr1:49525209-49546618 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0014927	protein coding gene	Chr1:51254545-51277607 (+)
WSB/EiJ	MGP_WSBEiJ_G0015424	protein coding gene	Chr1:51412718-51434628 (+)

Human Ortholog

NEMP2, nuclear envelope integral membrane protein 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

NEMP2, nuclear envelope integral membrane protein 2
Synonyms

TMEM194B
Links

HGNC:33700

NCBI Gene ID: 100131211

neXtProt AC: NX_A6NFY4

UniProt: A6NFY4
Chr Location

2q32.2; chr2:190421421-190648785 (-) GRCh38

MGI Vertebrate Homology

Nemp2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: NEMP2
Gene Tree

Nemp2

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Phenotype Summary

4 phenotypes from 1 allele in 1 genetic background
10 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Chemically induced (other)

1
Endonuclease-mediated

2
Gene trapped

1
Radiation induced

1
Targeted

2
Genomic Mutations

2 involving Nemp2
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

13 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

2
GO References

2

Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.

Biological Process

No experimental evidence to support Biological Process annotation, following literature review. See J:73796.

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

32

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

ZFIN nemp2

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All Sequences

54
RefSeq

4
UniProt

5
CCDS

CCDS48257.1

Ensembl

ENSMUSG00000043015 (Evidence)
NCBI Gene

227094

			Length	Strain/Species	Flank
genomic	ENSMUSG00000043015	Ensembl Gene Model \| MGI Sequence Detail	21217	C57BL/6J	± kb
transcript	ENSMUST00000165859	Ensembl \| MGI Sequence Detail	3396	Not Applicable
polypeptide	ENSMUSP00000129351	Ensembl \| MGI Sequence Detail	421	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000030376 nuclear envelope integral membrane protein 2

(term hierarchy)
InterPro Domains

IPR019358 NEMP family

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All nucleic 34

Genomic 2

cDNA 32

Microarray probesets 2

Summaries

All 29

Gene Ontology 2

Phenotypes 10
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582

TSS for Nemp2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr6678	Chr1:52669851-52669916 (+)	22 bp
Tssr6679	Chr1:52676667-52676672 (+)	6,808 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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