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Ankrd27 Gene Detail
Summary
  • Symbol
    Ankrd27
  • Name
    ankyrin repeat domain 27 (VPS9 domain)
  • Synonyms
    D330003H11Rik, MGC:25907, Varp
  • Feature Type
    protein coding gene
  • IDs
    MGI:2444103
    NCBI Gene: 245886
  • Gene Overview
    MyGene.info: ANKRD27
Location & Maps
more
  • Sequence Map
    Chr7:35586244-35639226 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      52983 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 21.37 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    ANKRD27, ankyrin repeat domain 27
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ANKRD27, ankyrin repeat domain 27
    Orthology source: HomoloGene, HGNC
  • Synonyms
    PP12899, VARP
  • Links
    NCBI Gene ID: 84079
    neXtProt AC: NX_Q96NW4

  • Chr Location
    19q13.11; chr19:32597001-32675196 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    13
  • Gene trapped
    10
  • Targeted
    3
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000049776 VEGA Gene Model | MGI Sequence Detail 52983 C57BL/6J ±  kb
transcript OTTMUST00000126781 VEGA | MGI Sequence Detail 4284 Not Applicable  
polypeptide OTTMUSP00000068544 VEGA | MGI Sequence Detail 1048 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    498 from dbSNP Build 142
Protein
Information
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  • UniProt
    8 Sequences
  • Protein Ontology
    PR:000004046 ankyrin repeat domain-containing protein 27
  • InterPro Domains
    IPR002110 Ankyrin repeat
    IPR020683 Ankyrin repeat-containing domain
    IPR003123 VPS9 domain
Molecular
Reagents
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  • All nucleic 82
    cDNA 81
    Primer pair 1

    Microarray probesets 4
Other
Accession IDs
less
MGI:2141812, MGI:2384295
References
more
  • Summaries
    All 41
    Developmental Gene Expression 1
    Gene Ontology 8
    Phenotypes 8
  • Earliest
    J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
  • Latest
    J:220987 Yatsu A, et al., Rab40C is a novel Varp-binding protein that promotes proteasomal degradation of Varp in melanocytes. Biol Open. 2015;4(3):267-75

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
09/27/2016
MGI 6.05
The Jackson Laboratory