Ppm1e
Gene Detail

Symbol Name ID

Ppm1e protein phosphatase 1E (PP2C domain containing) MGI:2444096

Synonyms

B930008A12Rik, mKIAA1072, POPX1, PP2CH

Feature Type

protein coding gene

Genetic Map

Chromosome 11

51.99 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr11:87226906-87359023 bp, - strand From VEGA annotation of GRCm38   132118 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:22848  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Ppm1e

Human homologs

Human Homolog		PPM1E, protein phosphatase, Mg2+/Mn2+ dependent, 1E
NCBI Gene ID		22843
Human Synonyms		caMKN, CaMKP-N, POPX1, PP2CH
Human Chr (Location)		17q22; chr17:56833230-57062540 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(6) : Targeted(5) Gene trapped(1)

Gene Ontology (GO) classifications

All GO classifications: (18 annotations)

Process	cellular response to drug, negative regulation of protein kinase activity, ...
Component	cytoplasm, mitochondrion, ...
Function	catalytic activity, hydrolase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (1 records)
Data Summary: Results (43)    Tissues (29)    Images (13)
Theiler Stages: 19, 23, 28

Assay Type	Results
RNA in situ	43

cDNA source data(6)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(7) Genomic(1) cDNA(6)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000001239 (Evidence)
Ensembl Gene Model	ENSMUSG00000046442 (Evidence)
Entrez Gene	320472 (Evidence)
DFCI	TC1586039, TC1596064, TC1624705, TC1627918, TC1721760
DoTS	DT.484124, DT.91413352, DT.97359630
NIA Mouse Gene Index	U033241
EC	3.1.3.16
Consensus CDS Project	CCDS25211.1
International Mouse Knockout Project Status	Ppm1e

Sequences

Length	Strain/Species
genomic	OTTMUSG00000001239	VEGA Gene Model | MGI Sequence Detail	132118	C57BL/6J
transcript	OTTMUST00000002470	VEGA | MGI Sequence Detail	6344	Not Applicable
polypeptide	OTTMUSP00000001216	VEGA | MGI Sequence Detail	749	Not Applicable

All sequences(36) RefSeq(2) UniProt(2)

Polymorphisms

SNPs(386 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR015655	Protein phosphatase 2C
InterPro	IPR000222	Protein phosphatase 2C, manganese/magnesium aspartate binding site
InterPro	IPR001932	Protein phosphatase 2C (PP2C)-like
Protein Ontology	PR:000013093	protein phosphatase 1E

References

(Earliest) J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
(Latest) J:194018 Chida T, et al., N-Myristoylation is essential for protein phosphatases PPM1A and PPM1B to dephosphorylate their physiological substrates in cells. Biochem J. 2013 Feb 1;449(3):741-9
All references(35)

Other accession IDs

MGI:2144485