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Tdrd3 Gene Detail
Summary
  • Symbol
    Tdrd3
  • Name
    tudor domain containing 3
  • Synonyms
    4732418C03Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2444023
    NCBI Gene: 219249
  • Gene Overview
    MyGene.info: TDRD3
  • Alliance
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:87416639-87545504 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 14, 44.17 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1272 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2444023
protein coding gene Chr14:87412305-87545508 (.)
129S1/SvImJ MGP_129S1SvImJ_G0021608
protein coding gene Chr14:82903127-83046168 (+)
A/J MGP_AJ_G0021566
protein coding gene Chr14:80715125-80844065 (+)
AKR/J MGP_AKRJ_G0021542
protein coding gene Chr14:83113729-83249011 (+)
BALB/cJ MGP_BALBcJ_G0021572
protein coding gene Chr14:80688153-80815993 (+)
C3H/HeJ MGP_C3HHeJ_G0021350
protein coding gene Chr14:82843255-82976900 (+)
C57BL/6NJ MGP_C57BL6NJ_G0022012
protein coding gene Chr14:86410686-86555073 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0019551
protein coding gene Chr14:78437678-78563951 (+)
CAST/EiJ MGP_CASTEiJ_G0020867
protein coding gene Chr14:79896945-80035736 (+)
CBA/J MGP_CBAJ_G0021318
protein coding gene Chr14:89353118-89488515 (+)
DBA/2J MGP_DBA2J_G0021442
protein coding gene Chr14:80069891-80201862 (+)
FVB/NJ MGP_FVBNJ_G0021418
protein coding gene Chr14:79378943-79505338 (+)
LP/J MGP_LPJ_G0021510
protein coding gene Chr14:83923911-84082898 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0021446
protein coding gene Chr14:89177854-89318346 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0022035
protein coding gene Chr14:82419348-82552259 (+)
PWK/PhJ MGP_PWKPhJ_G0020610
protein coding gene Chr14:76922819-77053835 (+)
SPRET/EiJ MGP_SPRETEiJ_G0020448
protein coding gene Chr14:78365148-78507970 (+)
WSB/EiJ MGP_WSBEiJ_G0020920
protein coding gene Chr14:82922919-83056461 (+)



Homology
more
  • Human Ortholog
    TDRD3, tudor domain containing 3
  • Vertebrate Orthologs
    10
  • Human Ortholog
    TDRD3, tudor domain containing 3
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 81550
    neXtProt AC: NX_Q9H7E2
    UniProt: Q9H7E2

  • Chr Location
    13q21.2; chr13:60396457-60573879 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 12771
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: TDRD3
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous mice for a hypomorphic allele show increased genomic instability, and increased c-Myc/Igh translocation and R loop formation in B cells.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000022019 Ensembl Gene Model | MGI Sequence Detail 128866 C57BL/6J ±  kb
transcript ENSMUST00000168275 Ensembl | MGI Sequence Detail 2657 Not Applicable  
polypeptide ENSMUSP00000129019 Ensembl | MGI Sequence Detail 743 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 69
    cDNA 69

    Microarray probesets 6
References
more
  • Summaries
    All 33
    Gene Ontology 3
    Phenotypes 13
  • Earliest
    J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-Le-Grand). 1999 Jul;45(5):737-50
  • Latest
    J:210647 Yang Y, et al., Arginine methylation facilitates the recruitment of TOP3B to chromatin to prevent R loop accumulation. Mol Cell. 2014 Feb 6;53(3):484-97

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory