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Fam20b Gene Detail
Summary
  • Symbol
    Fam20b
  • Name
    family with sequence similarity 20, member B
  • Synonyms
    C530043G21Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2443990
    NCBI Gene: 215015
  • Gene Overview
    MyGene.info: FAM20B
Location & Maps
more
  • Sequence Map
    Chr1:156678532-156719086 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      40555 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 67.71 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    FAM20B, FAM20B, glycosaminoglycan xylosylkinase
  • Vertebrate Orthologs
    10
  • Human Ortholog
    FAM20B, FAM20B, glycosaminoglycan xylosylkinase
    Orthology source: HomoloGene, HGNC
  • Synonyms
    gxk1
  • Links
    NCBI Gene ID: 9917
    neXtProt AC: NX_O75063

  • Chr Location
    1q25.2; chr1:179025809-179076567 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 8909
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: FAM20B
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotypes from 1 allele in 1 genetic background
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    9
  • Chemically induced (other)
    2
  • Gene trapped
    5
  • Targeted
    2
  • Genomic Mutations
    2 involving Fam20b
  • Incidental Mutations
Mice homozygous for a gene trapped allele exhibit complete embryonic lethality associated with decreased embryo size, multisystem organ hypoplasia, and delayed skeleton, digestive system, eye, liver, and lung development.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000029656 VEGA Gene Model | MGI Sequence Detail 40555 C57BL/6J ±  kb
transcript OTTMUST00000073573 VEGA | MGI Sequence Detail 4532 Not Applicable  
polypeptide OTTMUSP00000038111 VEGA | MGI Sequence Detail 409 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    401 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 142
    cDNA 141
    Primer pair 1

    Microarray probesets 4
References
more
  • Summaries
    All 27
    Developmental Gene Expression 1
    Gene Ontology 3
    Phenotypes 9
  • Earliest
    J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
  • Latest
    J:227247 Brommage R, et al., High-throughput screening of mouse gene knockouts identifies established and novel skeletal phenotypes. Bone Res. 2014;2:14034

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory