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Fam20b Gene Detail
Summary
  • Symbol
    Fam20b
  • Name
    family with sequence similarity 20, member B
  • Synonyms
    C530043G21Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2443990
    NCBI Gene: 215015
  • Gene Overview
    MyGene.info: FAM20B
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:156678545-156719027 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 67.71 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    401 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2443990
protein coding gene Chr1:156678532-156719086 (-)
129S1/SvImJ MGP_129S1SvImJ_G0016627
protein coding gene Chr1:161649487-161693013 (-)
A/J MGP_AJ_G0016608
protein coding gene Chr1:155152019-155191779 (-)
AKR/J MGP_AKRJ_G0016574
protein coding gene Chr1:159886244-159925514 (-)
BALB/cJ MGP_BALBcJ_G0016569
protein coding gene Chr1:155647021-155686784 (-)
C3H/HeJ MGP_C3HHeJ_G0016393
protein coding gene Chr1:160015187-160059216 (-)
C57BL/6NJ MGP_C57BL6NJ_G0017030
protein coding gene Chr1:167184691-167238613 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014739
protein coding gene Chr1:147349251-147388688 (-)
CAST/EiJ MGP_CASTEiJ_G0015973
protein coding gene Chr1:159566703-159612456 (-)
CBA/J MGP_CBAJ_G0016368
protein coding gene Chr1:173098361-173147849 (-)
DBA/2J MGP_DBA2J_G0016474
protein coding gene Chr1:154098862-154138649 (-)
FVB/NJ MGP_FVBNJ_G0016472
protein coding gene Chr1:152556864-152596850 (-)
LP/J MGP_LPJ_G0016545
protein coding gene Chr1:162779037-162820385 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0016497
protein coding gene Chr1:180616035-180660759 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0017066
protein coding gene Chr1:159701982-159746400 (-)
PWK/PhJ MGP_PWKPhJ_G0015759
protein coding gene Chr1:153196118-153236444 (-)
SPRET/EiJ MGP_SPRETEiJ_G0015546
protein coding gene Chr1:158449947-158491805 (-)
WSB/EiJ MGP_WSBEiJ_G0016035
protein coding gene Chr1:159806773-159848273 (-)



Homology
more
  • Human Ortholog
    FAM20B, FAM20B, glycosaminoglycan xylosylkinase
  • Vertebrate Orthologs
    10
  • Human Ortholog
    FAM20B, FAM20B, glycosaminoglycan xylosylkinase
    Orthology source: HomoloGene, HGNC
  • Synonyms
    gxk1
  • Links
    NCBI Gene ID: 9917
    neXtProt AC: NX_O75063
    UniProt: O75063

  • Chr Location
    1q25.2; chr1:179025804-179076574 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 8909
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: FAM20B
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 1 allele in 1 genetic background
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a gene trapped allele exhibit complete embryonic lethality associated with decreased embryo size, multisystem organ hypoplasia, and delayed skeleton, digestive system, eye, liver, and lung development.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 215015 NCBI Gene Model | MGI Sequence Detail 40483 C57BL/6J ±  kb
    transcript NM_145413 RefSeq | MGI Sequence Detail 4238 C57BL/6  
    polypeptide Q8VCS3 UniProt | EBI | MGI Sequence Detail 409 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 144
      cDNA 143
      Primer pair 1

      Microarray probesets 4
    References
    more
    • Summaries
      All 36
      Developmental Gene Expression 1
      Gene Ontology 7
      Phenotypes 9
    • Earliest
      J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
    • Latest
      J:265607 Naba A, et al., Quantitative proteomic profiling of the extracellular matrix of pancreatic islets during the angiogenic switch and insulinoma progression. Sci Rep. 2017 Jan 10;7:40495

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory