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Fam20b Gene Detail
Summary
  • Symbol
    Fam20b
  • Name
    FAM20B, glycosaminoglycan xylosylkinase
  • Synonyms
    C530043G21Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2443990
    NCBI Gene: 215015
  • Alliance
    genome feature page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:156506102-156546656 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 67.71 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    1112 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2443990
 protein coding gene Chr1:156506102-156547204 (-)
129S1/SvImJ ENSMUSG00200006113
 protein coding gene Chr1:153952232-153992467 (-)
A/J ENSMUSG00195022609
 protein coding gene Chr1:153332172-153372162 (-)
AKR/J ENSMUSG00220005757
 protein coding gene Chr1:153124239-153164242 (-)
BALB/cJ ENSMUSG00180033624
 protein coding gene Chr1:153550131-153590092 (-)
C3H/HeJ ENSMUSG00175035588
 protein coding gene Chr1:153596152-153636142 (-)
C57BL/6NJ ENSMUSG00215037819
 protein coding gene Chr1:153492302-153532862 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014739
 protein coding gene Chr1:147349251-147388688 (-)
CAST/EiJ ENSTCUG00005005408
 protein coding gene Chr1:152145093-152186371 (-)
CBA/J ENSMUSG00210020877
 protein coding gene Chr1:153492529-153532510 (-)
DBA/2J ENSMUSG00185042901
 protein coding gene Chr1:157770198-157810183 (-)
FVB/NJ ENSMUSG00205009268
 protein coding gene Chr1:152626363-152666344 (-)
JF1/MsJ ENSUMUG00000008154
 protein coding gene Chr1:156921308-156961281 (-)
LP/J ENSMUSG00230016886
 protein coding gene Chr1:157336954-157377497 (-)
NOD/ShiLtJ ENSMUSG00190029637
 protein coding gene Chr1:153342925-153383479 (-)
NZO/HlLtJ ENSMUSG00225006068
 protein coding gene Chr1:161004921-161045474 (-)
PWK/PhJ ENSLUMG00010027103
 protein coding gene Chr1:152286814-152326564 (-)
SPRET/EiJ ENSMSPG00010036874
 protein coding gene Chr1:155626954-155666802 (-)
WSB/EiJ ENSIUOG00005014443
 protein coding gene Chr1:152925937-152966477 (-)



Homology
more
  • Human Ortholog
    FAM20B, FAM20B glycosaminoglycan xylosylkinase
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FAM20B, FAM20B glycosaminoglycan xylosylkinase
  • Synonyms
    gxk1
  • Links
    NCBI Gene ID: 9917
    UniProt: O75063

  • Chr Location
    1q25.2; chr1:179017334-179076567 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 2 alleles in 2 genetic backgrounds
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a gene trapped allele exhibit complete embryonic lethality associated with decreased embryo size, multisystem organ hypoplasia, and delayed skeleton, digestive system, eye, liver, and lung development.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    14
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    616
  • Tissues
    17
  • cDNA Data
    143
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000033557 Ensembl Gene Model | MGI Sequence Detail 40555 C57BL/6J ±  kb
    transcript ENSMUST00000122424 Ensembl | MGI Sequence Detail 4532 Not Applicable  
    polypeptide ENSMUSP00000112534 Ensembl | MGI Sequence Detail 409 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 146
      cDNA 143
      Primer pair 2
      Other 1

      Microarray probesets 4
    References
    more
    • Summaries
      All 48
      Developmental Gene Expression 4
      Gene Ontology 8
      Phenotypes 19
    • Earliest
      J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
    • Latest
      J:366552 Chen X, et al., FAM20B-Catalyzed Glycosylation Regulates the Chondrogenic and Osteogenic Differentiation of the Embryonic Condyle by Controlling IHH Diffusion and Release. Int J Mol Sci. 2025 Apr 24;26(9)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/15/2026
    MGI 6.29     		The Jackson Laboratory