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Gchfr Gene Detail
Summary
  • Symbol
    Gchfr
  • Name
    GTP cyclohydrolase I feedback regulator
  • Synonyms
    2010323F13Rik, P35
  • Feature Type
    protein coding gene
  • IDs
    MGI:2443977
    NCBI Gene: 320415
  • Gene Overview
    MyGene.info: GCHFR
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:119167788-119172389 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 59.97 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    107 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2443977
protein coding gene Chr2:119167773-119172390 (.)
129S1/SvImJ MGP_129S1SvImJ_G0026333
protein coding gene Chr2:121902797-121907094 (+)
A/J MGP_AJ_G0026294
protein coding gene Chr2:116942252-116946573 (+)
AKR/J MGP_AKRJ_G0026273
protein coding gene Chr2:120214900-120219216 (+)
BALB/cJ MGP_BALBcJ_G0026307
protein coding gene Chr2:117206027-117210342 (+)
C3H/HeJ MGP_C3HHeJ_G0026053
protein coding gene Chr2:120683721-120688055 (+)
C57BL/6NJ MGP_C57BL6NJ_G0026754
protein coding gene Chr2:125906602-125911218 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0024134
protein coding gene Chr2:111996913-112001518 (+)
CAST/EiJ MGP_CASTEiJ_G0025515
protein coding gene Chr2:120990189-120994507 (+)
CBA/J MGP_CBAJ_G0026029
protein coding gene Chr2:130341219-130345535 (+)
DBA/2J MGP_DBA2J_G0026168
protein coding gene Chr2:116369434-116373733 (+)
FVB/NJ MGP_FVBNJ_G0026130
protein coding gene Chr2:115188534-115192850 (+)
LP/J MGP_LPJ_G0026269
protein coding gene Chr2:122216749-122221070 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0026149
protein coding gene Chr2:134702589-134706889 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0026809
protein coding gene Chr2:120338771-120343079 (+)
PWK/PhJ MGP_PWKPhJ_G0025251
protein coding gene Chr2:115923504-115928261 (+)
SPRET/EiJ MGP_SPRETEiJ_G0025050
protein coding gene Chr2:119524961-119529605 (+)
WSB/EiJ MGP_WSBEiJ_G0025584
protein coding gene Chr2:121166249-121171362 (+)



Homology
more
  • Human Ortholog
    GCHFR, GTP cyclohydrolase I feedback regulator
  • Vertebrate Orthologs
    10
  • Human Ortholog
    GCHFR, GTP cyclohydrolase I feedback regulator
    Orthology source: HomoloGene, HGNC
  • Synonyms
    GFRP, HsT16933, P35
  • Links
    NCBI Gene ID: 2644
    neXtProt AC: NX_P30047
    UniProt: P30047

  • Chr Location
    15q15.1; chr15:40764087-40767713 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 3849
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: GCHFR
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 320415 NCBI Gene Model | MGI Sequence Detail 4602 C57BL/6J ±  kb
transcript NM_177157 RefSeq | MGI Sequence Detail 629 C57BL/6  
polypeptide P99025 UniProt | EBI | MGI Sequence Detail 84 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 37
    cDNA 37

    Microarray probesets 4
References
more
  • Summaries
    All 34
    Developmental Gene Expression 2
    Gene Ontology 6
    Phenotypes 8
  • Earliest
    J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
  • Latest
    J:237675 Wyler SC, et al., Pet-1 Controls Tetrahydrobiopterin Pathway and Slc22a3 Transporter Genes in Serotonin Neurons. ACS Chem Neurosci. 2015 Jul 15;6(7):1198-205

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory