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Dpp9 Gene Detail
Summary
  • Symbol
    Dpp9
  • Name
    dipeptidylpeptidase 9
  • Synonyms
    6430584G11Rik, DPRP2
  • Feature Type
    protein coding gene
  • IDs
    MGI:2443967
    NCBI Gene: 224897
  • Gene Overview
    MyGene.info: DPP9
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr17:56186807-56218889 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      32083 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 29.20 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    DPP9, dipeptidyl peptidase 9
  • Vertebrate Orthologs
    9
  • Human Ortholog
    DPP9, dipeptidyl peptidase 9
    Orthology source: HomoloGene, HGNC
  • Synonyms
    DP9, DPLP9, DPP IX, DPRP2, DPRP-2
  • Links
    NCBI Gene ID: 91039
    neXtProt AC: NX_Q86TI2
    UniProt: Q86TI2

  • Chr Location
    19p13.3; chr19:4675226-4723843 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    17 phenotypes from 4 alleles in 3 genetic backgrounds
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous mutants display partial neonatal lethality and complete lethality at preweaning stages with defects suckling due to undeveveloped tongue muscle.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000001229 Ensembl Gene Model | MGI Sequence Detail 32083 C57BL/6J ±  kb
    transcript ENSMUST00000038794 Ensembl | MGI Sequence Detail 3374 Not Applicable  
    polypeptide ENSMUSP00000046604 Ensembl | MGI Sequence Detail 862 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      6 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 73
      cDNA 72
      Other 1

      Microarray probesets 2
    References
    more
    • Summaries
      All 36
      Developmental Gene Expression 2
      Gene Ontology 3
      Phenotypes 16
    • Earliest
      J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
    • Latest
      J:251322 Kim M, et al., DPP9 enzyme activity controls survival of mouse migratory tongue muscle progenitors and its absence leads to neonatal lethality due to suckling defect. Dev Biol. 2017 Nov 15;431(2):297-308

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    10/09/2018
    MGI 6.12
    The Jackson Laboratory