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Mmp25
Gene Detail
Symbol

Name
ID
Mmp25
matrix metallopeptidase 25
MGI:2443938
Synonyms
F730048C11Rik, Leukolysin, MT6-MMP
Feature Type
protein coding gene
Genetic Map
Chromosome 17
11.87 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr17:23629458-23645269 bp, - strand
From NCBI annotation of GRCm38

  15812 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:23375  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 cattle; 1 dog; 1 western clawed frog; 2 zebrafish

HCOP human homology predictions: MMP25
Protein SuperFamily: matrix metalloproteinase, stromelysin type
Gene Tree: Mmp25

Human
homologs
MMP25, matrix metallopeptidase 25
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 64386
neXtProt AC: NX_Q9NPA2

Human Synonyms: MMP20, MMP20A, MMP-25, MMPL1, MT6MMP, MT6-MMP, MTMMP6, MT-MMP6, MT-MMP 6

Human Chr (Location): 16p13.3; chr16:3045963-3060729 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(9) : Gene trapped(7) Targeted(2)
Incidental mutations (data from Mutagenetix , APF , CvDC )
Interactions
Mmp25 interacts with 124 markers (Mir10a, Mir10b, Mir15b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (20 annotations)
Process hard palate development, inflammatory response, ...
Component anchored component of membrane, cell surface, ...
Function calcium ion binding, hydrolase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (12)    Tissues (1)    Images (12)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 12
cDNA source data(12)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase mmp25 ; ZFIN mmp25a    NEW 
Molecular
reagents
All nucleic(12) cDNA(12)
Microarray probesets(1)
Other database
links
Ensembl Gene Model ENSMUSG00000023903 (Evidence)
Entrez Gene 240047 (Evidence)
UniGene 235343
DFCI TC1583518, TC1649909
DoTS DT.99855405, DT.91391562, DT.110565624
NIA Mouse Gene Index U037498
EC 3.4.24.-
Consensus CDS Project CCDS28452.1
International Mouse Phenotyping Consortium Status Mmp25
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 240047 NCBI Gene Model | MGI Sequence Detail 15812 C57BL/6J ±  kb
transcript NM_001033339 RefSeq | MGI Sequence Detail 3373 C57BL/6 
polypeptide Q3U435 UniProt | EBI | MGI Sequence Detail 615 Not Applicable 

For the selected sequences
All sequences(20) RefSeq(2) UniProt(1)
Polymorphisms
SNPs within 2kb(147 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000585 Hemopexin-like domain
InterPro IPR018487 Hemopexin-like repeats
InterPro IPR024079 Metallopeptidase, catalytic domain
InterPro IPR021190 Peptidase M10A
InterPro IPR016293 Peptidase M10A, metazoans
InterPro IPR001818 Peptidase M10, metallopeptidase
InterPro IPR006026 Peptidase, metallopeptidase
InterPro IPR002477 Peptidoglycan binding-like
Protein Ontology PR:000010484 matrix metalloproteinase-25
Graphical View of Protein Domain Structure
References
(Earliest) J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
(Latest) J:213098 Tocchi A, et al., Functional interactions between matrix metalloproteinases and glycosaminoglycans. FEBS J. 2013 May;280(10):2332-41
All references(30)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory