Mmp25
Gene Detail

Symbol Name ID

Mmp25 matrix metallopeptidase 25 MGI:2443938

Synonyms

F730048C11Rik, Leukolysin, MT6-MMP

Feature Type

protein coding gene

Genetic Map

Chromosome 17

11.87 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr17:23629458-23645269 bp, - strand From NCBI annotation of GRCm38   15812 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:23375  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 2 zebrafish

Protein SuperFamily: matrix metalloproteinase, stromelysin type
Gene Tree: Mmp25

Human homologs

Human Homolog		MMP25, matrix metallopeptidase 25
NCBI Gene ID		64386
neXtProt AC		NX_Q9NPA2
Human Synonyms		MMP20, MMP20A, MMP-25, MMPL1, MT6MMP, MT6-MMP, MTMMP6, MT-MMP6, MT-MMP 6
Human Chr (Location)		16p13.3; chr16:3096682-3110727 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(7) : Gene trapped(7)

Gene Ontology (GO) classifications

All GO classifications: (19 annotations)

Process	hard palate development, positive regulation of peptidase activity, ...
Component	anchored to membrane, cell surface, ...
Function	calcium ion binding, hydrolase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (2 records)
Data Summary: Results (12)    Tissues (1)    Images (12)
Theiler Stages: 23

Assay Type	Results
RNA in situ	12

cDNA source data(12)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(12) cDNA(12)
Microarray probesets(1)

Other database links

Ensembl Gene Model	ENSMUSG00000023903 (Evidence)
Entrez Gene	240047 (Evidence)
UniGene	235343
DFCI	TC1583518, TC1649909
DoTS	DT.110565624, DT.91391562, DT.99855405
NIA Mouse Gene Index	U037498
EC	3.4.24.-
Consensus CDS Project	CCDS28452.1
International Mouse Knockout Project Status	Mmp25

Sequences

Length	Strain/Species
genomic	240047	NCBI Gene Model | MGI Sequence Detail	15812	C57BL/6J
transcript	NM_001033339	RefSeq | MGI Sequence Detail	3373	C57BL/6
polypeptide	Q3U435	UniProt | EBI | MGI Sequence Detail	615	Not Applicable

All sequences(20) RefSeq(2) UniProt(1)

Polymorphisms

SNPs(88 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000585	Hemopexin/matrixin
InterPro	IPR018487	Hemopexin/matrixin, repeat
InterPro	IPR024079	Metallopeptidase, catalytic domain
InterPro	IPR021190	Peptidase M10A, matrix metallopeptidase
InterPro	IPR016293	Peptidase M10A, matrix metallopeptidase, stromelysin type
InterPro	IPR001818	Peptidase M10, metallopeptidase
InterPro	IPR006026	Peptidase, metallopeptidase
InterPro	IPR002477	Peptidoglycan binding-like
Protein Ontology	PR:000010484	matrix metalloproteinase-25

Graphical View of Protein Domain Structure

References

(Earliest) J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(31)