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Lcor Gene Detail
Summary
  • Symbol
    Lcor
  • Name
    ligand dependent nuclear receptor corepressor
  • Synonyms
    3110023F06Rik, A630025C20Rik, Gm340, LOC381224, mKIAA1795, Mlr2
  • Feature Type
    protein coding gene
  • IDs
    MGI:2443930
    NCBI Gene: 212391
  • Gene Overview
    MyGene.info: LCOR
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:41482637-41586536 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 19, 34.97 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    395 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2443930
protein coding gene Chr19:41482637-41596161 (+)
129S1/SvImJ MGP_129S1SvImJ_G0025123
protein coding gene Chr19:40745002-40835602 (+)
A/J MGP_AJ_G0025100
protein coding gene Chr19:38790020-38869926 (+)
AKR/J MGP_AKRJ_G0025068
protein coding gene Chr19:40071700-40157736 (+)
BALB/cJ MGP_BALBcJ_G0025094
protein coding gene Chr19:38849867-38934799 (+)
C3H/HeJ MGP_C3HHeJ_G0024854
protein coding gene Chr19:40213834-40294541 (+)
C57BL/6NJ MGP_C57BL6NJ_G0025538
protein coding gene Chr19:41836378-41920270 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0022951
protein coding gene Chr19:38158683-38234490 (+)
CAST/EiJ MGP_CASTEiJ_G0024319
protein coding gene Chr19:39879208-39962452 (+)
CBA/J MGP_CBAJ_G0024834
protein coding gene Chr19:43863830-43951862 (+)
DBA/2J MGP_DBA2J_G0024966
protein coding gene Chr19:38645546-38726224 (+)
FVB/NJ MGP_FVBNJ_G0024927
protein coding gene Chr19:38411654-38491429 (+)
LP/J MGP_LPJ_G0025052
protein coding gene Chr19:40753947-40837630 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0024958
protein coding gene Chr19:43513656-43598715 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0025595
protein coding gene Chr19:40112405-40194408 (+)
PWK/PhJ MGP_PWKPhJ_G0024069
protein coding gene Chr19:38515831-38597988 (+)
SPRET/EiJ MGP_SPRETEiJ_G0023872
protein coding gene Chr19:38840867-38926807 (+)
WSB/EiJ MGP_WSBEiJ_G0024389
protein coding gene Chr19:40263187-40346057 (+)



Homology
more
  • Human Ortholog
    LCOR, ligand dependent nuclear receptor corepressor
  • Vertebrate Orthologs
    5
  • Human Ortholog
    LCOR, ligand dependent nuclear receptor corepressor
    Orthology source: HomoloGene, HGNC
  • Synonyms
    C10orf12, MLR2
  • Links
    NCBI Gene ID: 84458
    neXtProt AC: NX_Q96JN0
    UniProt: Q96JN0

  • Chr Location
    10q24.1; chr10:96832250-96964441 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 2 alleles in 2 genetic backgrounds
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele die between E11.5 and birth.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000025019 Ensembl Gene Model | MGI Sequence Detail 103900 C57BL/6J ±  kb
transcript ENSMUST00000238398 Ensembl | MGI Sequence Detail 5764 Not Applicable  
polypeptide ENSMUSP00000158715 Ensembl | MGI Sequence Detail 1696 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    6 Sequences
  • InterPro Domains
    IPR007889 DNA binding HTH domain, Psq-type
    IPR009057 Homeobox-like domain superfamily
    IPR028104 Protein of unknown function DUF4553
Molecular
Reagents
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  • All nucleic 26
    cDNA 24
    Primer pair 1
    Other 1

    Microarray probesets 5
Other
Accession IDs
less
MGI:1920403, MGI:2685186
References
more
  • Summaries
    All 47
    Developmental Gene Expression 10
    Gene Ontology 7
    Phenotypes 13
  • Earliest
    J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-Le-Grand). 1999 Jul;45(5):737-50
  • Latest
    J:262633 Shukunami C, et al., Scleraxis is a transcriptional activator that regulates the expression of Tenomodulin, a marker of mature tenocytes and ligamentocytes. Sci Rep. 2018 Feb 16;8(1):3155

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
11/10/2020
MGI 6.16
The Jackson Laboratory