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Rasal2 Gene Detail
Summary
  • Symbol
    Rasal2
  • Name
    RAS protein activator like 2
  • Synonyms
    A330066M24Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2443881
    NCBI Gene: 226525
  • Gene Overview
    MyGene.info: RASAL2
  • Alliance
  • Transcription Start Sites
    12 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:156962752-157240165 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 67.97 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    1832 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2443881
protein coding gene Chr1:156962752-157240170 (-)
129S1/SvImJ MGP_129S1SvImJ_G0016631
protein coding gene Chr1:162141166-162443033 (-)
A/J MGP_AJ_G0016612
protein coding gene Chr1:155610668-155890409 (-)
AKR/J MGP_AKRJ_G0016578
protein coding gene Chr1:160360737-160652455 (-)
BALB/cJ MGP_BALBcJ_G0016573
protein coding gene Chr1:156112395-156391089 (-)
C3H/HeJ MGP_C3HHeJ_G0016397
protein coding gene Chr1:160495042-160791677 (-)
C57BL/6NJ MGP_C57BL6NJ_G0017034
protein coding gene Chr1:167699360-168011409 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014743
protein coding gene Chr1:147805762-148075020 (-)
CAST/EiJ MGP_CASTEiJ_G0015977
protein coding gene Chr1:160058222-160334607 (-)
CBA/J MGP_CBAJ_G0016372
protein coding gene Chr1:173635385-173956428 (-)
DBA/2J MGP_DBA2J_G0016478
protein coding gene Chr1:154558177-154836363 (-)
FVB/NJ MGP_FVBNJ_G0016476
protein coding gene Chr1:153013901-153285600 (-)
LP/J MGP_LPJ_G0016549
protein coding gene Chr1:163274222-163557731 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0016501
protein coding gene Chr1:181139458-181494050 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0017070
protein coding gene Chr1:160185139-160479767 (-)
PWK/PhJ MGP_PWKPhJ_G0015763
protein coding gene Chr1:153658827-153941707 (-)
SPRET/EiJ MGP_SPRETEiJ_G0015550
protein coding gene Chr1:158922375-159216811 (-)
WSB/EiJ MGP_WSBEiJ_G0016039
protein coding gene Chr1:160293464-160590028 (-)



Homology
more
  • Human Ortholog
    RASAL2, RAS protein activator like 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RASAL2, RAS protein activator like 2
  • Synonyms
    NGAP
  • Links
    NCBI Gene ID: 9462
    neXtProt AC: NX_Q9UJF2
    UniProt: Q9UJF2

  • Chr Location
    1q25.2; chr1:178093729-178479514 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 2 alleles in 2 genetic backgrounds
    9 phenotypes from multigenic genotypes
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a gene trap allele exhibit reduced survival and decreased tumor latency. In other tumorigenic models, this allele promotes increase metastatic potential.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000070565 Ensembl Gene Model | MGI Sequence Detail 277414 C57BL/6J ±  kb
    transcript ENSMUST00000078308 Ensembl | MGI Sequence Detail 10047 Not Applicable  
    polypeptide ENSMUSP00000077423 Ensembl | MGI Sequence Detail 1286 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 16
      cDNA 16

      Microarray probesets 2
    References
    more
    • Summaries
      All 27
      Developmental Gene Expression 2
      Gene Ontology 2
      Phenotypes 12
    • Earliest
      J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
    • Latest
      J:298397 Wang B, et al., Silencing of lncRNA SNHG20 delays the progression of nonalcoholic fatty liver disease to hepatocellular carcinoma via regulating liver Kupffer cells polarization. IUBMB Life. 2019 Dec;71(12):1952-1961

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.
    last database update
    11/23/2021
    MGI 6.17
    The Jackson Laboratory