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Rasal2 Gene Detail
Summary
  • Symbol
    Rasal2
  • Name
    RAS protein activator like 2
  • Synonyms
    A330066M24Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2443881
    NCBI Gene: 226525
  • Gene Overview
    MyGene.info: RASAL2
  • Alliance
    gene page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:157135183-157412595 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 67.97 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    1838 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2443881
 protein coding gene Chr1:157135182-157412595 (-)
129S1/SvImJ MGP_129S1SvImJ_G0016631
 protein coding gene Chr1:162141166-162443033 (-)
A/J MGP_AJ_G0016612
 protein coding gene Chr1:155610668-155890409 (-)
AKR/J MGP_AKRJ_G0016578
 protein coding gene Chr1:160360737-160652455 (-)
BALB/cJ MGP_BALBcJ_G0016573
 protein coding gene Chr1:156112395-156391089 (-)
C3H/HeJ MGP_C3HHeJ_G0016397
 protein coding gene Chr1:160495042-160791677 (-)
C57BL/6NJ MGP_C57BL6NJ_G0017034
 protein coding gene Chr1:167699360-168011409 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014743
 protein coding gene Chr1:147805762-148075020 (-)
CAST/EiJ MGP_CASTEiJ_G0015977
 protein coding gene Chr1:160058222-160334607 (-)
CBA/J MGP_CBAJ_G0016372
 protein coding gene Chr1:173635385-173956428 (-)
DBA/2J MGP_DBA2J_G0016478
 protein coding gene Chr1:154558177-154836363 (-)
FVB/NJ MGP_FVBNJ_G0016476
 protein coding gene Chr1:153013901-153285600 (-)
LP/J MGP_LPJ_G0016549
 protein coding gene Chr1:163274222-163557731 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0016501
 protein coding gene Chr1:181139458-181494050 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0017070
 protein coding gene Chr1:160185139-160479767 (-)
PWK/PhJ MGP_PWKPhJ_G0015763
 protein coding gene Chr1:153658827-153941707 (-)
SPRET/EiJ MGP_SPRETEiJ_G0015550
 protein coding gene Chr1:158922375-159216811 (-)
WSB/EiJ MGP_WSBEiJ_G0016039
 protein coding gene Chr1:160293464-160590028 (-)



Homology
more
  • Human Ortholog
    RASAL2, RAS protein activator like 2
  • Vertebrate Orthologs
    9
  • Human Ortholog
    RASAL2, RAS protein activator like 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    NGAP
  • Links
    NCBI Gene ID: 9462
    neXtProt AC: NX_Q9UJF2
    UniProt: Q9UJF2

  • Chr Location
    1q25.2; chr1:178093729-178479514 (+)  GRCh38.p7
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 2 alleles in 2 genetic backgrounds
    9 phenotypes from multigenic genotypes
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a gene trap allele exhibit reduced survival and decreased tumor latency. In other tumorigenic models, this allele promotes increase metastatic potential.
Gene Ontology
(GO)
Classifications
less
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    177
  • Tissues
    22
  • cDNA Data
    16
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 226525 NCBI Gene Model | MGI Sequence Detail 277413 C57BL/6J ±  kb
    transcript NM_177644 RefSeq | MGI Sequence Detail 10046 C57BL/6  
    polypeptide NP_808312 RefSeq | MGI Sequence Detail 1286 C57BL/6  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 16
      cDNA 16

      Microarray probesets 2
    References
    more
    • Summaries
      All 25
      Developmental Gene Expression 1
      Phenotypes 11
    • Earliest
      J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
    • Latest
      J:202603 McLaughlin SK, et al., The RasGAP gene, RASAL2, is a tumor and metastasis suppressor. Cancer Cell. 2013 Sep 9;24(3):365-78
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
    Warranty Disclaimer & Copyright Notice
    Send questions and comments to User Support.     		last database update
    03/13/2019
    MGI 6.13     		The Jackson Laboratory