Rasal2 MGI Mouse Gene Detail - MGI:2443881 - RAS protein activator like 2

Rasal2 Gene Detail

Symbol

Rasal2
Name

RAS protein activator like 2
Synonyms

A330066M24Rik

Feature Type

protein coding gene
IDs

MGI:2443881
NCBI Gene: 226525
Gene Overview

MyGene.info: RASAL2

Sequence Map

Chr1:157135182-157412595 bp, - strand
From VEGA annotation of GRCm38

Mouse Genome Browser
Download
Sequence

277414 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 67.97 cM
Mapping Data

1 experiment

Human Ortholog

RASAL2, RAS protein activator like 2

Vertebrate Orthologs

9

Human Ortholog

RASAL2, RAS protein activator like 2
Orthology source: HomoloGene, HGNC
Synonyms

NGAP
Links

HGNC:9874

NCBI Gene ID: 9462

neXtProt AC: NX_Q9UJF2

UniProt: Q9UJF2
Chr Location

1q25.2; chr1:178093729-178479514 (+) GRCh38.p7

HomoloGene

Vertebrate Homology Class 35217
1 human;1 mouse;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
HCOP

human homology predictions: RASAL2
Gene Tree

Rasal2

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Phenotype Summary

6 phenotypes from 2 alleles in 2 genetic backgrounds
9 phenotypes from multigenic genotypes
11 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

14
Chemically induced (other)

2
Gene trapped

7
Targeted

4
Transposon induced

1
Genomic Mutations

2 involving Rasal2
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

39 strains or lines available

Mice homozygous for a gene trap allele exhibit reduced survival and decreased tumor latency. In other tumorigenic models, this allele promotes increase metastatic potential.

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All GO Annotations

4
GO References

1

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	receptor	receptor binding	RNA binding	transcription	transferase	transporter

Biological Process

nucleic acid-templated transcription	carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

177
Tissues

22
cDNA Data

14
Literature Summary

1

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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Rasal2 interacts with 482 markers (Mir1a-1, Mir1a-2, Mir1b, ...) View All

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All Sequences

66
RefSeq

16
UniProt

8
CCDS

CCDS48408.1

			Length	Strain/Species	Flank
genomic	OTTMUSG00000033172	VEGA Gene Model \| MGI Sequence Detail	277414	C57BL/6J	± kb
transcript	OTTMUST00000082979	VEGA \| MGI Sequence Detail	10047	Not Applicable
polypeptide	OTTMUSP00000044526	VEGA \| MGI Sequence Detail	1286	Not Applicable

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SNPs within 2kb

1838 from dbSNP Build 142

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UniProt

8 Sequences
InterPro Domains

IPR000008 C2 domain

IPR021887 Domain of unknown function DUF3498

IPR011993 PH domain-like

IPR001849 Pleckstrin homology domain

IPR001936 Ras GTPase-activating protein

IPR023152 Ras GTPase-activating protein, conserved site

IPR008936 Rho GTPase activation protein

IPR023315 SynGAP C2 domain, N-terminal

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All nucleic 14

cDNA 14

Microarray probesets 2

Summaries

All 26

Developmental Gene Expression 1

Gene Ontology 1

Phenotypes 11
Earliest

J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
Latest

J:202603 McLaughlin SK, et al., The RasGAP gene, RASAL2, is a tumor and metastasis suppressor. Cancer Cell. 2013 Sep 9;24(3):365-78

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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