Zbtb11 MGI Mouse Gene Detail - MGI:2443876 - zinc finger and BTB domain containing 11

Symbol

Zbtb11
Name

zinc finger and BTB domain containing 11
Synonyms

9230110G02Rik, ZNF-U69274

Feature Type

protein coding gene
IDs

MGI:2443876
NCBI Gene: 271377
Alliance

genome feature page
Transcription Start Sites

5 TSS

Sequence Map

Chr16:55794246-55829276 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 16, 33.74 cM
Mapping Data

1 experiment

SNPs within 2kb

891 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2443876	protein coding gene	Chr16:55791820-55829276 (+)
129S1/SvImJ	ENSMUSG00200020681	protein coding gene	Chr16:52694411-52729487 (+)
A/J	ENSMUSG00195024124	protein coding gene	Chr16:52313214-52348245 (+)
AKR/J	ENSMUSG00220019423	protein coding gene	Chr16:52688440-52723472 (+)
BALB/cJ	ENSMUSG00180022396	protein coding gene	Chr16:52482695-52517729 (+)
C3H/HeJ	ENSMUSG00175016754	protein coding gene	Chr16:52778597-52813631 (+)
C57BL/6NJ	ENSMUSG00215012986	protein coding gene	Chr16:52599782-52634816 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0020810	protein coding gene	Chr16:52424855-52459043 (+)
CAST/EiJ	ENSTCUG00005013896	protein coding gene	Chr16:52822416-52855752 (+)
CBA/J	ENSMUSG00210019423	protein coding gene	Chr16:52796773-52832196 (+)
DBA/2J	ENSMUSG00185025227	protein coding gene	Chr16:52662723-52697753 (+)
FVB/NJ	ENSMUSG00205009114	protein coding gene	Chr16:52451559-52486633 (+)
JF1/MsJ	ENSUMUG00000018327	protein coding gene	Chr16:52909042-52944464 (+)
LP/J	ENSMUSG00230006470	protein coding gene	Chr16:55223447-55258524 (+)
NOD/ShiLtJ	ENSMUSG00190007173	protein coding gene	Chr16:52700881-52735911 (+)
NZO/HlLtJ	ENSMUSG00225025700	protein coding gene	Chr16:58322574-58357604 (+)
PWK/PhJ	ENSLUMG00010011086	protein coding gene	Chr16:52720197-52755262 (+)
SPRET/EiJ	ENSMSPG00010001379	protein coding gene	Chr16:53169709-53202904 (+)
WSB/EiJ	ENSIUOG00005008722	protein coding gene	Chr16:52914194-52949221 (+)

Human Ortholog

ZBTB11, zinc finger and BTB domain containing 11

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ZBTB11, zinc finger and BTB domain containing 11
Synonyms

MRT69, ZNF913, ZNF-U69274
Links

HGNC:16740

NCBI Gene ID: 27107

UniProt: O95625
Chr Location

3q12.3; chr3:101648889-101677135 (-) GRCh38

MGI Vertebrate Homology

Zbtb11 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: ZBTB11
Gene Tree

Zbtb11

Diseases

1 with human ZBTB11 associations

				Human Disease	Mouse Models
				autosomal recessive intellectual developmental disorder 69 IDs autosomal recessive intellectual developmental disorder 69 DOID:0081230 OMIM:618383

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

17 phenotypes from 1 allele in 1 genetic background
9 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

10
Endonuclease-mediated

4
Gene trapped

5
Targeted

1
Find Mice (IMSR)

28 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice with loss of expression in hematopoietic cells show prenatal lethality with hematopoietic failure and impaired homing of progenitor cells to the bone marrow.

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All GO Annotations

9
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

635
Tissues

37
cDNA Data

56
Literature Summary

4

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase zbtb11

ZFIN zbtb11

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All Sequences

41
RefSeq

10
UniProt

2
CCDS

CCDS49874.1

Ensembl

ENSMUSG00000022601 (Evidence)
NCBI Gene

271377

			Length	Strain/Species	Flank
genomic	ENSMUSG00000022601	Ensembl Gene Model \| MGI Sequence Detail	35031	C57BL/6J	± kb
transcript	ENSMUST00000050248	Ensembl \| MGI Sequence Detail	4920	Not Applicable
polypeptide	ENSMUSP00000056923	Ensembl \| MGI Sequence Detail	1050	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000017563 zinc finger and BTB domain-containing protein 11

(term hierarchy)
InterPro Domains

IPR000210 BTB/POZ domain

IPR041588 Integrase zinc-binding domain

IPR011333 SKP1/BTB/POZ domain superfamily

IPR048060 Zinc finger and BTB domain-containing protein 11, BTB/POZ domain

IPR036236 Zinc finger C2H2 superfamily

IPR013087 Zinc finger C2H2-type

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All nucleic 58

cDNA 56

Primer pair 1

Other 1

Microarray probesets 1

Summaries

All 35

Developmental Gene Expression 4

Gene Ontology 6

Phenotypes 9
Earliest

J:8000 Balcarek JM, et al., Structure of the mouse glial fibrillary acidic protein gene: implications for the evolution of the intermediate filament multigene family. Nucleic Acids Res. 1985 Aug 12;13(15):5527-43
Latest

J:343208 Cao H, et al., Late fetal hematopoietic failure results from ZBTB11 deficiency despite abundant HSC specification. Blood Adv. 2023 Nov 14;7(21):6506-6519

TSS for Zbtb11:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr138799	Chr16:55794149-55794163 (+)	-90 bp
Tssr138800	Chr16:55794174-55794193 (+)	-62 bp
Tssr138801	Chr16:55794200-55794227 (+)	-32 bp
Tssr138802	Chr16:55794244-55794255 (+)	4 bp
Tssr138803	Chr16:55795535-55795570 (+)	1,307 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/08/2026 MGI 6.24