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Lipi Gene Detail
Summary
  • Symbol
    Lipi
  • Name
    lipase, member I
  • Synonyms
    D930038D03Rik, lpd1
  • Feature Type
    protein coding gene
  • IDs
    MGI:2443868
    NCBI Gene: 320355
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:75540514-75586061 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 16, 43.22 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    150 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2443868
protein coding gene Chr16:75540514-75586072 (-)
129S1/SvImJ MGP_129S1SvImJ_G0022952
protein coding gene Chr16:75565302-75609271 (-)
A/J MGP_AJ_G0022920
protein coding gene Chr16:72244895-72288688 (-)
AKR/J MGP_AKRJ_G0022890
protein coding gene Chr16:74434729-74482488 (-)
BALB/cJ MGP_BALBcJ_G0022922
protein coding gene Chr16:72630216-72672581 (-)
C3H/HeJ MGP_C3HHeJ_G0022684
protein coding gene Chr16:74894535-74939474 (-)
C57BL/6NJ MGP_C57BL6NJ_G0023370
protein coding gene Chr16:78002820-78050825 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020873
protein coding gene Chr16:70819083-70860169 (-)
CAST/EiJ MGP_CASTEiJ_G0022207
protein coding gene Chr16:75291049-75347101 (-)
CBA/J MGP_CBAJ_G0022654
protein coding gene Chr16:81329401-81372745 (-)
DBA/2J MGP_DBA2J_G0022787
protein coding gene Chr16:72082014-72123105 (-)
FVB/NJ MGP_FVBNJ_G0022762
protein coding gene Chr16:71468821-71509482 (-)
LP/J MGP_LPJ_G0022857
protein coding gene Chr16:75345293-75392846 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0022780
protein coding gene Chr16:84396873-84470569 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0023387
protein coding gene Chr16:74769280-74820786 (-)
PWK/PhJ MGP_PWKPhJ_G0021949
protein coding gene Chr16:72338658-72382712 (-)
SPRET/EiJ MGP_SPRETEiJ_G0021779
protein coding gene Chr16:74384462-74429804 (-)
WSB/EiJ MGP_WSBEiJ_G0022254
protein coding gene Chr16:74944575-74989419 (-)



Homology
more
  • Human Ortholog
    LIPI, lipase I
  • Vertebrate Orthologs
    6
  • Human Ortholog
    LIPI, lipase I
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CT17, LPDL, mPA-PLA1 beta, PLA1C, PRED5
  • Links
    NCBI Gene ID: 149998
    neXtProt AC: NX_Q6XZB0
    UniProt: Q6XZB0

  • Chr Location
    21q11.2; chr21:14108813-14210953 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 1 allele in 1 genetic background
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a transgenic gene disruption exhibit postnatal lethality, tremors, abnormal gait, decreased body weight, retarded hair growth, and a defect in triglyceride metabolism resulting in hypertriglyceridemia and hepatic steatosis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000032948 Ensembl Gene Model | MGI Sequence Detail 45548 C57BL/6J ±  kb
    transcript ENSMUST00000062721 Ensembl | MGI Sequence Detail 2082 Not Applicable  
    polypeptide ENSMUSP00000053447 Ensembl | MGI Sequence Detail 476 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 4
      cDNA 4

      Microarray probesets 2
    References
    more
    • Summaries
      All 24
      Developmental Gene Expression 1
      Gene Ontology 2
      Phenotypes 8
    • Earliest
      J:46789 Wen XY, et al., Characterization of lpd (lipid defect): a novel mutation on mouse chromosome 16 associated with a defect in triglyceride metabolism. Hum Mol Genet. 1998 Apr;7(4):743-50
    • Latest
      J:262380 Watson-Scales S, et al., Analysis of motor dysfunction in Down Syndrome reveals motor neuron degeneration. PLoS Genet. 2018 May;14(5):e1007383

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    last database update
    11/26/2019
    MGI 6.14
    The Jackson Laboratory