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Tsku Gene Detail
Summary
  • Symbol
    Tsku
  • Name
    tsukushi, small leucine rich proteoglycan
  • Synonyms
    9530051K01Rik, Lrrc54
  • Feature Type
    protein coding gene
  • IDs
    MGI:2443855
    NCBI Gene: 244152
  • Alliance
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:97999875-98010535 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 7, 53.66 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    163 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2443855
protein coding gene Chr7:97999875-98010602 (-)
129S1/SvImJ MGP_129S1SvImJ_G0032538
protein coding gene Chr7:101073466-101084118 (-)
A/J MGP_AJ_G0032512
protein coding gene Chr7:98580750-98591413 (-)
AKR/J MGP_AKRJ_G0032448
protein coding gene Chr7:100923572-100934232 (-)
BALB/cJ MGP_BALBcJ_G0032523
protein coding gene Chr7:98270215-98280863 (-)
C3H/HeJ MGP_C3HHeJ_G0032238
protein coding gene Chr7:101277352-101287888 (-)
C57BL/6NJ MGP_C57BL6NJ_G0033021
protein coding gene Chr7:104994434-105005088 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0030016
protein coding gene Chr7:101022736-101034241 (-)
CAST/EiJ MGP_CASTEiJ_G0031565
protein coding gene Chr7:92793516-92804083 (-)
CBA/J MGP_CBAJ_G0032205
protein coding gene Chr7:108566652-108577188 (-)
DBA/2J MGP_DBA2J_G0032357
protein coding gene Chr7:96909103-96919639 (-)
FVB/NJ MGP_FVBNJ_G0032313
protein coding gene Chr7:96713405-96724037 (-)
LP/J MGP_LPJ_G0032446
protein coding gene Chr7:102405205-102415859 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0032346
protein coding gene Chr7:110103449-110114105 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0033043
protein coding gene Chr7:100193580-100204231 (-)
PWK/PhJ MGP_PWKPhJ_G0031283
protein coding gene Chr7:89996958-90007609 (-)
SPRET/EiJ MGP_SPRETEiJ_G0031126
protein coding gene Chr7:87470372-87481674 (-)
WSB/EiJ MGP_WSBEiJ_G0031682
protein coding gene Chr7:100853470-100864120 (-)



Homology
more
  • Human Ortholog
    TSKU, tsukushi, small leucine rich proteoglycan
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TSKU, tsukushi, small leucine rich proteoglycan
  • Synonyms
    E2IG4, LRRC54, TSK
  • Links
    NCBI Gene ID: 25987
    neXtProt AC: NX_Q8WUA8
    UniProt: Q8WUA8

  • Chr Location
    11q13.5; chr11:76782251-76798153 (+)  GRCh38

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    29 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit a failure of anterior commissure axons to cross the midline.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000049580 Ensembl Gene Model | MGI Sequence Detail 10661 C57BL/6J ±  kb
    transcript ENSMUST00000164726 Ensembl | MGI Sequence Detail 2620 Not Applicable  
    polypeptide ENSMUSP00000130917 Ensembl | MGI Sequence Detail 354 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 16
      cDNA 14
      Primer pair 1
      Other 1

      Microarray probesets 2
    References
    more
    • Summaries
      All 52
      Developmental Gene Expression 9
      Gene Ontology 13
      Phenotypes 29
    • Earliest
      J:88307 Giometti CS, et al., The analysis of recessive lethal mutations in mice by using two-dimensional gel electrophoresis of liver proteins. Mutat Res. 1990 Sep;242(1):47-55
    • Latest
      J:331988 Istiaq A, et al., Tsukushi proteoglycan maintains RNA splicing and developmental signaling network in GFAP-expressing subventricular zone neural stem/progenitor cells. Front Cell Dev Biol. 2022;10:994588

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    last database update
    03/12/2024
    MGI 6.23
    The Jackson Laboratory