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Sdk2 Gene Detail
Summary
  • Symbol
    Sdk2
  • Name
    sidekick cell adhesion molecule 2
  • Synonyms
    4632412F08Rik, 5330435L01Rik, mKIAA1514
  • Feature Type
    protein coding gene
  • IDs
    MGI:2443847
    NCBI Gene: 237979
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:113667200-113957855 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 79.30 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2713 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2443847
 protein coding gene Chr11:113667200-113957872 (-)
129S1/SvImJ MGP_129S1SvImJ_G0019355
 protein coding gene Chr11:117619444-117920135 (-)
A/J MGP_AJ_G0019324
 protein coding gene Chr11:112546269-112833809 (-)
AKR/J MGP_AKRJ_G0019292
 protein coding gene Chr11:115862326-116155071 (-)
BALB/cJ MGP_BALBcJ_G0019297
 protein coding gene Chr11:112955537-113245012 (-)
C3H/HeJ MGP_C3HHeJ_G0019106
 protein coding gene Chr11:116210347-116512281 (-)
C57BL/6NJ MGP_C57BL6NJ_G0019748
 protein coding gene Chr11:121144818-121453988 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017371
 protein coding gene Chr11:109621937-109903240 (-)
CAST/EiJ MGP_CASTEiJ_G0018660
 protein coding gene Chr11:117487504-117796590 (-)
CBA/J MGP_CBAJ_G0019076
 protein coding gene Chr11:126067136-126395829 (-)
DBA/2J MGP_DBA2J_G0019188
 protein coding gene Chr11:111981990-112270205 (-)
FVB/NJ MGP_FVBNJ_G0019179
 protein coding gene Chr11:111459675-111748162 (-)
LP/J MGP_LPJ_G0019258
 protein coding gene Chr11:118058011-118351754 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0019210
 protein coding gene Chr11:125231636-125534357 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0019785
 protein coding gene Chr11:116515003-116816556 (-)
PWK/PhJ MGP_PWKPhJ_G0018425
 protein coding gene Chr11:113194448-113488901 (-)
SPRET/EiJ MGP_SPRETEiJ_G0018217
 protein coding gene Chr11:116319929-116618284 (-)
WSB/EiJ MGP_WSBEiJ_G0018712
 protein coding gene Chr11:116481193-116779048 (-)



Homology
more
  • Human Ortholog
    SDK2, sidekick cell adhesion molecule 2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SDK2, sidekick cell adhesion molecule 2
  • Links
    NCBI Gene ID: 54549
    neXtProt AC: NX_Q58EX2
    UniProt: Q58EX2

  • Chr Location
    17q25.1; chr17:73334384-73644445 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 2 alleles in 2 genetic backgrounds
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit impaired interconnectvity between VG3 amacrine cells and W3B retinal ganglion cells.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    11
  • GO References
    4
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    843
  • Tissues
    50
  • cDNA Data
    10
  • Literature Summary
    7
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 237979 NCBI Gene Model | MGI Sequence Detail 290656 C57BL/6J ±  kb
transcript NM_172800 RefSeq | MGI Sequence Detail 8300 C57BL/6  
polypeptide Q6V4S5 UniProt | EBI | MGI Sequence Detail 2176 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 12
    cDNA 10
    Primer pair 1
    Other 1

    Microarray probesets 5
Other
Accession IDs
less
MGI:1922965
References
more
  • Summaries
    All 38
    Developmental Gene Expression 7
    Gene Ontology 4
    Phenotypes 9
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:344905 Rochon PL, et al., The cell adhesion molecule Sdk1 shapes assembly of a retinal circuit that detects localized edges. Elife. 2021 Sep 21;10:e70870
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory